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ECSP003599A - Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres - Google Patents

Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres

Info

Publication number
ECSP003599A
ECSP003599A EC2000003599A ECSP003599A ECSP003599A EC SP003599 A ECSP003599 A EC SP003599A EC 2000003599 A EC2000003599 A EC 2000003599A EC SP003599 A ECSP003599 A EC SP003599A EC SP003599 A ECSP003599 A EC SP003599A
Authority
EC
Ecuador
Prior art keywords
coroepoxi
esteres
alfa
procedure
acids
Prior art date
Application number
EC2000003599A
Other languages
English (en)
Inventor
Ann M Diederich
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of ECSP003599A publication Critical patent/ECSP003599A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Esta invención se refiere a un método para preparar ciertos ácidos de la fórmula (I): (gráfico), a través de un cloroepoxi-éster, que son útiles como inhibidores de la fosfo diesterasa 4.
EC2000003599A 1999-08-06 2000-08-02 Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres ECSP003599A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14757699P 1999-08-06 1999-08-06

Publications (1)

Publication Number Publication Date
ECSP003599A true ECSP003599A (es) 2002-03-25

Family

ID=22522121

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2000003599A ECSP003599A (es) 1999-08-06 2000-08-02 Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres

Country Status (26)

Country Link
EP (1) EP1200394B1 (es)
JP (1) JP2003506431A (es)
KR (1) KR20020022793A (es)
CN (4) CN1597675A (es)
AR (1) AR025028A1 (es)
AT (1) ATE340780T1 (es)
AU (1) AU774582B2 (es)
BR (1) BR0013025A (es)
CA (1) CA2381010A1 (es)
CO (1) CO5190744A1 (es)
CZ (1) CZ2002428A3 (es)
DE (1) DE60030981T2 (es)
EC (1) ECSP003599A (es)
ES (1) ES2272310T3 (es)
HK (1) HK1047080A1 (es)
HU (1) HUP0202453A2 (es)
IL (1) IL147365A0 (es)
MX (1) MXPA02001337A (es)
NO (1) NO20020561L (es)
NZ (1) NZ516945A (es)
PE (1) PE20010398A1 (es)
PL (1) PL353347A1 (es)
TR (1) TR200200307T2 (es)
UY (1) UY26268A1 (es)
WO (1) WO2001010822A1 (es)
ZA (1) ZA200200965B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101116828B (zh) * 2006-08-03 2011-06-01 中国科学院大连化学物理研究所 手性吡啶双噁唑啉催化剂及制备方法和应用
WO2016172496A1 (en) 2015-04-23 2016-10-27 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and uses thereof
US10517849B2 (en) 2016-10-26 2019-12-31 Constellation Pharmaceuticals, Inc. LSD1 inhibitors and medical uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3803593A (en) * 1992-04-02 1993-11-08 Smithkline Beecham Corporation Compounds
AU3924993A (en) * 1992-04-02 1993-11-08 Smithkline Beecham Corporation Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor
US5552438A (en) * 1992-04-02 1996-09-03 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
JP3195352B2 (ja) * 1992-04-02 2001-08-06 スミスクライン・ビーチャム・コーポレイション アレルギーおよび炎症疾患の治療用化合物
GB9404706D0 (en) * 1994-03-11 1994-04-27 Smithkline Beecham Corp Compounds
UY24882A1 (es) * 1997-02-12 2001-08-27 Smithkline Beecham Corp Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos

Also Published As

Publication number Publication date
AU6622200A (en) 2001-03-05
HUP0202453A2 (en) 2002-10-28
EP1200394A1 (en) 2002-05-02
JP2003506431A (ja) 2003-02-18
EP1200394B1 (en) 2006-09-27
TR200200307T2 (tr) 2002-05-21
EP1200394A4 (en) 2004-12-01
NZ516945A (en) 2004-01-30
ZA200200965B (en) 2003-04-30
UY26268A1 (es) 2001-01-31
CN1530360A (zh) 2004-09-22
AR025028A1 (es) 2002-11-06
CN1368955A (zh) 2002-09-11
NO20020561D0 (no) 2002-02-05
CN1597675A (zh) 2005-03-23
PL353347A1 (en) 2003-11-17
DE60030981T2 (de) 2007-09-06
HK1047080A1 (zh) 2003-02-07
CN1217923C (zh) 2005-09-07
CA2381010A1 (en) 2001-02-15
CO5190744A1 (es) 2002-08-29
NO20020561L (no) 2002-02-05
CN1530362A (zh) 2004-09-22
BR0013025A (pt) 2002-04-16
KR20020022793A (ko) 2002-03-27
WO2001010822A1 (en) 2001-02-15
DE60030981D1 (de) 2006-11-09
AU774582B2 (en) 2004-07-01
MXPA02001337A (es) 2002-07-22
CN1266119C (zh) 2006-07-26
ATE340780T1 (de) 2006-10-15
ES2272310T3 (es) 2007-05-01
IL147365A0 (en) 2002-08-14
CZ2002428A3 (cs) 2002-06-12
PE20010398A1 (es) 2001-06-14

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