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EA202192530A1 - Соединения, композиции и способы - Google Patents

Соединения, композиции и способы

Info

Publication number
EA202192530A1
EA202192530A1 EA202192530A EA202192530A EA202192530A1 EA 202192530 A1 EA202192530 A1 EA 202192530A1 EA 202192530 A EA202192530 A EA 202192530A EA 202192530 A EA202192530 A EA 202192530A EA 202192530 A1 EA202192530 A1 EA 202192530A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
compositions
compounds
tautomer
stereoisomer
Prior art date
Application number
EA202192530A
Other languages
English (en)
Inventor
Хавьер Де Висенте Фидальго
Энтони А. Эстрада
Цзяньвэнь А. Фэн
Закари К. Суини
Original Assignee
Денали Терапьютикс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Денали Терапьютикс Инк. filed Critical Денали Терапьютикс Инк.
Publication of EA202192530A1 publication Critical patent/EA202192530A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение в целом относится к ингибиторам LRRK2 или их фармацевтически приемлемой соли, изотопно обогащенному аналогу, таутомеру, стереоизомеру, смеси стереоизомеров, пролекарству или фармацевтической композиции и способам их получения и применения.
EA202192530A 2019-04-11 2020-04-10 Соединения, композиции и способы EA202192530A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962832775P 2019-04-11 2019-04-11
PCT/US2020/027742 WO2020210684A1 (en) 2019-04-11 2020-04-10 Compounds, compositions and methods

Publications (1)

Publication Number Publication Date
EA202192530A1 true EA202192530A1 (ru) 2022-03-15

Family

ID=72752101

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192530A EA202192530A1 (ru) 2019-04-11 2020-04-10 Соединения, композиции и способы

Country Status (18)

Country Link
US (1) US20220220094A1 (ru)
EP (1) EP3953348B1 (ru)
JP (1) JP7623294B2 (ru)
KR (1) KR20210151887A (ru)
CN (1) CN113939294A (ru)
AR (1) AR118641A1 (ru)
AU (1) AU2020272045A1 (ru)
BR (1) BR112021020027A2 (ru)
CA (1) CA3136447A1 (ru)
DK (1) DK3953348T3 (ru)
EA (1) EA202192530A1 (ru)
IL (1) IL287120B1 (ru)
MA (1) MA55624A (ru)
MX (1) MX2021012392A (ru)
SG (1) SG11202111058XA (ru)
TW (1) TWI851710B (ru)
WO (1) WO2020210684A1 (ru)
ZA (1) ZA202107499B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA51339A (fr) 2017-12-20 2020-10-28 Denali Therapeutics Inc Procédé de préparation de composés pyrimidinyl-4-aminopyrazole
US20230391775A1 (en) * 2020-10-29 2023-12-07 Suzhou Yabao Pharmaceutical R&D Co., Ltd. Substituted diarylamine compound, pharmaceutical composition thereof, preparation method therefor, and use thereof
CN116120291B (zh) * 2023-04-11 2023-06-30 英矽智能科技(上海)有限公司 吲唑类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3590933B1 (en) 2010-11-10 2021-01-06 Genentech, Inc. Pyrazole aminopyrimidine derivatives as lrrk2 modulators
UA126231C2 (uk) * 2016-06-16 2022-09-07 Деналі Терапьютікс Інк. Піримідин-2-іламіно-1н-піразоли як інгібітори lrrk2 для застосування при лікуванні нейродегенеративних захворювань
US20200157081A1 (en) 2017-05-24 2020-05-21 Denali Therapeutics Inc. Compounds, compositions and methods
MA51339A (fr) * 2017-12-20 2020-10-28 Denali Therapeutics Inc Procédé de préparation de composés pyrimidinyl-4-aminopyrazole

Also Published As

Publication number Publication date
AU2020272045A1 (en) 2021-10-28
DK3953348T3 (da) 2025-03-17
US20220220094A1 (en) 2022-07-14
ZA202107499B (en) 2022-06-29
JP7623294B2 (ja) 2025-01-28
JP2022526015A (ja) 2022-05-20
AR118641A1 (es) 2021-10-20
IL287120B1 (en) 2025-02-01
EP3953348A4 (en) 2023-01-18
SG11202111058XA (en) 2021-11-29
EP3953348A1 (en) 2022-02-16
IL287120A (en) 2021-12-01
TWI851710B (zh) 2024-08-11
EP3953348B1 (en) 2024-12-18
WO2020210684A1 (en) 2020-10-15
MX2021012392A (es) 2021-11-12
CA3136447A1 (en) 2020-10-15
CN113939294A (zh) 2022-01-14
MA55624A (fr) 2022-02-16
BR112021020027A2 (pt) 2021-12-07
TW202104213A (zh) 2021-02-01
KR20210151887A (ko) 2021-12-14

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