[go: up one dir, main page]

EA202191478A1 - Гетероароматические соединения в качестве ингибиторов ванина - Google Patents

Гетероароматические соединения в качестве ингибиторов ванина

Info

Publication number
EA202191478A1
EA202191478A1 EA202191478A EA202191478A EA202191478A1 EA 202191478 A1 EA202191478 A1 EA 202191478A1 EA 202191478 A EA202191478 A EA 202191478A EA 202191478 A EA202191478 A EA 202191478A EA 202191478 A1 EA202191478 A1 EA 202191478A1
Authority
EA
Eurasian Patent Office
Prior art keywords
heteroaromatic compounds
vanin
compounds
inhibitors
vanin inhibitors
Prior art date
Application number
EA202191478A
Other languages
English (en)
Inventor
Седриккс Годбу
Мартин Томас Флек
Ханнес Фипко Кольман
Томас Мартин мл. Киррейн
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA202191478A1 publication Critical patent/EA202191478A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к соединениям формулы Iкоторые пригодны для лечения заболеваний, связанных с ванином, и способам приготовления таких соединений, фармацевтическим препаратам, содержащим эти соединения, и способам их применения.
EA202191478A 2018-12-03 2019-12-02 Гетероароматические соединения в качестве ингибиторов ванина EA202191478A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862774412P 2018-12-03 2018-12-03
PCT/EP2019/083259 WO2020114947A1 (en) 2018-12-03 2019-12-02 Heteroaromatic compounds as vanin inhibitors

Publications (1)

Publication Number Publication Date
EA202191478A1 true EA202191478A1 (ru) 2021-10-26

Family

ID=68766765

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202191478A EA202191478A1 (ru) 2018-12-03 2019-12-02 Гетероароматические соединения в качестве ингибиторов ванина

Country Status (14)

Country Link
US (1) US12240828B2 (ru)
EP (1) EP3890828B1 (ru)
JP (1) JP7195436B2 (ru)
KR (1) KR20210099093A (ru)
CN (1) CN113226462B (ru)
AU (1) AU2019392524B2 (ru)
BR (1) BR112021010823A2 (ru)
CA (1) CA3120037A1 (ru)
DK (1) DK3890828T3 (ru)
EA (1) EA202191478A1 (ru)
ES (1) ES3026660T3 (ru)
MX (1) MX2021006489A (ru)
PL (1) PL3890828T3 (ru)
WO (1) WO2020114947A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113166104A (zh) * 2018-12-03 2021-07-23 勃林格殷格翰国际有限公司 作为vanin抑制剂的杂芳族化合物
JP2022513745A (ja) * 2018-12-11 2022-02-09 エフ．ホフマン－ラ ロシュ アーゲー アミノアジンアミド
TWI794994B (zh) * 2020-09-25 2023-03-01 大陸商上海美悅生物科技發展有限公司 嘧啶甲醯胺類化合物及其應用
WO2022127909A1 (zh) * 2020-12-17 2022-06-23 上海美悦生物科技发展有限公司 一种嘧啶甲酰胺类化合物及其应用
TWI848622B (zh) * 2022-03-18 2024-07-11 大陸商上海美悦生物科技發展有限公司 Ｖａｎｉｎ酶抑制劑的鹽型、晶型及其製備方法和用途
CN116903592A (zh) * 2023-07-13 2023-10-20 特科罗生物科技(成都)有限公司 一种嘧啶胺类nuak抑制剂及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030195192A1 (en) 2002-04-05 2003-10-16 Fortuna Haviv Nicotinamides having antiangiogenic activity
ATE419242T1 (de) 2003-10-09 2009-01-15 Abbott Lab Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
CN103087050A (zh) * 2011-10-28 2013-05-08 山东轩竹医药科技有限公司 芳基激酶抑制剂
CN104703965A (zh) 2012-09-25 2015-06-10 默克专利股份有限公司 α羟基酰胺
US9221807B2 (en) * 2014-02-21 2015-12-29 Boehringer Ingelheim International Gmbh Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity
JP2018516254A (ja) * 2015-05-29 2018-06-21 ファイザー・インク バニン１酵素の阻害薬としての新規なヘテロ環化合物
EP3390390B1 (en) * 2015-12-16 2021-09-01 Boehringer Ingelheim International Gmbh Bipyrazolyl derivatives useful for the treatment of autoimmune diseases
MX2019000536A (es) 2016-07-14 2019-04-01 Pfizer Nuevas pirimidinas carboxamidas como inhibidores de enzima vanina-1.
DK3638680T3 (da) 2017-06-12 2022-09-05 Boehringer Ingelheim Int Heteroaromatiske forbindelser som vanininhibitorer
US10864201B2 (en) 2018-08-28 2020-12-15 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as Vanin inhibitors
CN113166104A (zh) * 2018-12-03 2021-07-23 勃林格殷格翰国际有限公司 作为vanin抑制剂的杂芳族化合物

Also Published As

Publication number Publication date
BR112021010823A2 (pt) 2021-08-24
MX2021006489A (es) 2021-07-06
EP3890828A1 (en) 2021-10-13
ES3026660T3 (en) 2025-06-11
US20220048889A1 (en) 2022-02-17
AU2019392524B2 (en) 2025-05-08
DK3890828T3 (da) 2025-05-05
JP2022510351A (ja) 2022-01-26
CN113226462A (zh) 2021-08-06
JP7195436B2 (ja) 2022-12-23
PL3890828T3 (pl) 2025-06-16
KR20210099093A (ko) 2021-08-11
WO2020114947A1 (en) 2020-06-11
CN113226462B (zh) 2025-02-11
AU2019392524A1 (en) 2021-07-15
CA3120037A1 (en) 2020-06-11
EP3890828B1 (en) 2025-02-19
US12240828B2 (en) 2025-03-04

Similar Documents

Publication Publication Date Title
EA202190588A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
PH12021551065A1 (en) Fused ring compounds
EA201792047A1 (ru) Новые соединения
EA202191478A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA201891494A1 (ru) Гетероциклические соединения в качестве иммуномодуляторов
EA202191476A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA201790492A1 (ru) СОЕДИНЕНИЯ, КОТОРЫЕ ИНГИБИРУЮТ БЕЛОК Mcl-1
EA201592068A1 (ru) Ингибиторы энхансера zeste гомолога 2
MY197440A (en) Heteroamatic compounds as btk inhibitors
EA202090014A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA201792421A1 (ru) Амидозамещенные производные циклогексана
EA201891063A1 (ru) Производные дигидроимидазопиразинона, применимые в лечении рака
EA202090448A1 (ru) Дигидрооксадиазиноны
EA202090414A1 (ru) Соединения и их применение
EA201790949A1 (ru) Замещенные 2,4-диаминохинолины в качестве новых противораковых средств
EA201790070A1 (ru) Бифениламиды, содержащие модифицированные простые эфирные группы, в качестве ингибиторов hsp90 и стимуляторов hsp70
EA201692481A1 (ru) Комбинация, содержащая глюкокортикоид и edo-s101
EA202091003A1 (ru) Новые производные пиразолопирролопиримидиндиона в качестве ингибиторов p2x3
EA201791432A1 (ru) Композиции на основе пролекарства монометилфумарата
EA201501187A1 (ru) Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
EA201792341A1 (ru) Производные пиразола, пригодные в качестве ингибиторов белка, активирующего 5-липоксигеназу (flap)
EA202191477A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA201990947A1 (ru) Замещенные производные 6-(1h-пиразол-1-ил)пиримидин-4-амина и их применение
EA202092446A1 (ru) ТИАЗОЛ- ИЛИ ТИАДИАЗОЛЗАМЕЩЕННЫЕ АРИЛЬНЫЕ И ГЕТЕРОАРИЛЬНЫЕ ПРОИЗВОДНЫЕ КАК ИНГИБИТОРЫ Vps34
EA201891680A1 (ru) Производные индана в качестве модуляторов mglur7