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EA202190243A1 - Применение химерных антигенных рецепторов к bcma - Google Patents

Применение химерных антигенных рецепторов к bcma

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Publication number
EA202190243A1
EA202190243A1 EA202190243A EA202190243A EA202190243A1 EA 202190243 A1 EA202190243 A1 EA 202190243A1 EA 202190243 A EA202190243 A EA 202190243A EA 202190243 A EA202190243 A EA 202190243A EA 202190243 A1 EA202190243 A1 EA 202190243A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bcma
application
chimeric antigenic
antigenic receptors
chimeric
Prior art date
Application number
EA202190243A
Other languages
English (en)
Inventor
Кристен Хидж
Пайал Пател
Стивен Новик
Ларс Стернас
Original Assignee
Селджин Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селджин Корпорейшн filed Critical Селджин Корпорейшн
Publication of EA202190243A1 publication Critical patent/EA202190243A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0636—T lymphocytes
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C12N2510/00—Genetically modified cells

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  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Developmental Biology & Embryology (AREA)

Abstract

В данном изобретении предложено применение химерных антигенных рецепторов (CAR) к антигену созревания B-клеток (BCMA) для лечения патологических состояний, связанных с B-клетками, таких как рак, экспрессирующий BCMA.
EA202190243A 2018-07-11 2019-07-10 Применение химерных антигенных рецепторов к bcma EA202190243A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862696802P 2018-07-11 2018-07-11
PCT/US2019/041165 WO2020014333A1 (en) 2018-07-11 2019-07-10 Uses of anti-bcma chimeric antigen receptors

Publications (1)

Publication Number Publication Date
EA202190243A1 true EA202190243A1 (ru) 2021-06-16

Family

ID=67660447

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190243A EA202190243A1 (ru) 2018-07-11 2019-07-10 Применение химерных антигенных рецепторов к bcma

Country Status (14)

Country Link
US (1) US20210330788A1 (ru)
EP (2) EP4223269A3 (ru)
JP (2) JP2021530483A (ru)
KR (1) KR20210045985A (ru)
CN (1) CN112689516A (ru)
AU (1) AU2019301126A1 (ru)
BR (1) BR112021000249A2 (ru)
CA (1) CA3105813A1 (ru)
EA (1) EA202190243A1 (ru)
IL (1) IL280033A (ru)
MX (1) MX2021000283A (ru)
SG (1) SG11202100160SA (ru)
TW (1) TW202019474A (ru)
WO (1) WO2020014333A1 (ru)

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KR20240112994A (ko) * 2021-11-03 2024-07-19 셀진 코포레이션 골수종을 치료하는 데 사용하기 위한 b-세포 성숙 항원에 특이적인 키메라 항원 수용체
WO2023077343A1 (en) * 2021-11-04 2023-05-11 Janssen Biotech, Inc. Bcma-targeted car-t cell therapy for multiple myeloma
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Also Published As

Publication number Publication date
BR112021000249A2 (pt) 2021-04-06
CN112689516A (zh) 2021-04-20
JP2021530483A (ja) 2021-11-11
US20210330788A1 (en) 2021-10-28
EP4223269A2 (en) 2023-08-09
MX2021000283A (es) 2021-06-18
AU2019301126A1 (en) 2021-02-04
KR20210045985A (ko) 2021-04-27
JP2024161391A (ja) 2024-11-19
SG11202100160SA (en) 2021-02-25
IL280033A (en) 2021-03-01
CA3105813A1 (en) 2020-01-16
TW202019474A (zh) 2020-06-01
WO2020014333A1 (en) 2020-01-16
EP3820515A1 (en) 2021-05-19
EP4223269A3 (en) 2023-08-30

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