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EA202090176A1 - COMPOSITIONS AND METHODS OF APPLICATION 2- (4-CHLOROPHENYL) -N - ((2- (2,6-DIOXOPIPERIDIN-3-IL) -1-OXOISOINDOLIN-5-IL) METHYL) -2,2-DIFLUOROCETAMAMIDE - Google Patents

COMPOSITIONS AND METHODS OF APPLICATION 2- (4-CHLOROPHENYL) -N - ((2- (2,6-DIOXOPIPERIDIN-3-IL) -1-OXOISOINDOLIN-5-IL) METHYL) -2,2-DIFLUOROCETAMAMIDE

Info

Publication number
EA202090176A1
EA202090176A1 EA202090176A EA202090176A EA202090176A1 EA 202090176 A1 EA202090176 A1 EA 202090176A1 EA 202090176 A EA202090176 A EA 202090176A EA 202090176 A EA202090176 A EA 202090176A EA 202090176 A1 EA202090176 A1 EA 202090176A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dioxopiperidin
oxoisoindolin
chlorophenyl
methyl
methods
Prior art date
Application number
EA202090176A
Other languages
Russian (ru)
Inventor
Тонья Дж. Бачхолз
Джеймс Кармайкл
Сорайя Каррансио
Цзиньхун Фань
Раджан Гупта
Ган Лу
Кайл Макбет
Эмили Пейс
Дениэл Пирс
Майкл Пурдехнад
Ю Пью
Пэн Ван
Найцзюнь У
Шина Яо
Original Assignee
Селджин Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селджин Корпорейшн filed Critical Селджин Корпорейшн
Priority claimed from PCT/US2018/040286 external-priority patent/WO2019006299A1/en
Publication of EA202090176A1 publication Critical patent/EA202090176A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В данном изобретении предложены составы и способы применения 2-(4-хлорфенил)-N-((2-(2,6-диоксопиперидин-3-ил)-1-оксоизоиндолин-5-ил)метил)-2,2-дифторацетамида, или его стереоизомера, или смеси стереоизомеров, фармацевтически приемлемой соли, таутомера, пролекарства, сольвата, гидрата, сокристалла, клатрата или полиморфа.The present invention provides compositions and methods for using 2- (4-chlorophenyl) -N - ((2- (2,6-dioxopiperidin-3-yl) -1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide or a stereoisomer thereof, or a mixture of stereoisomers, a pharmaceutically acceptable salt, tautomer, prodrug, solvate, hydrate, cocrystal, clathrate or polymorph.

EA202090176A 2018-05-17 2018-06-29 COMPOSITIONS AND METHODS OF APPLICATION 2- (4-CHLOROPHENYL) -N - ((2- (2,6-DIOXOPIPERIDIN-3-IL) -1-OXOISOINDOLIN-5-IL) METHYL) -2,2-DIFLUOROCETAMAMIDE EA202090176A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862673064P 2018-05-17 2018-05-17
PCT/US2018/040286 WO2019006299A1 (en) 2017-06-30 2018-06-29 Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-doxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide

Publications (1)

Publication Number Publication Date
EA202090176A1 true EA202090176A1 (en) 2020-05-06

Family

ID=70847682

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090176A EA202090176A1 (en) 2018-05-17 2018-06-29 COMPOSITIONS AND METHODS OF APPLICATION 2- (4-CHLOROPHENYL) -N - ((2- (2,6-DIOXOPIPERIDIN-3-IL) -1-OXOISOINDOLIN-5-IL) METHYL) -2,2-DIFLUOROCETAMAMIDE

Country Status (1)

Country Link
EA (1) EA202090176A1 (en)

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