[go: up one dir, main page]

EA201892497A1 - Способы лечения гетеротопической оссификации - Google Patents

Способы лечения гетеротопической оссификации

Info

Publication number
EA201892497A1
EA201892497A1 EA201892497A EA201892497A EA201892497A1 EA 201892497 A1 EA201892497 A1 EA 201892497A1 EA 201892497 A EA201892497 A EA 201892497A EA 201892497 A EA201892497 A EA 201892497A EA 201892497 A1 EA201892497 A1 EA 201892497A1
Authority
EA
Eurasian Patent Office
Prior art keywords
heterotopic
assessment
treatment
methods
reduce
Prior art date
Application number
EA201892497A
Other languages
English (en)
Inventor
Кларисса Десжардинс
Донна Рой Гроган
Джеффри Нил Пэкмен
Марк Харнетт
Original Assignee
Клементиа Фармасьютикалз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Клементиа Фармасьютикалз Инк. filed Critical Клементиа Фармасьютикалз Инк.
Publication of EA201892497A1 publication Critical patent/EA201892497A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В изобретении предлагаются схемы введения и фармацевтические составы для перорального введения паловаротена. Посредством предложенных схем введения можно уменьшить гетеротопическую оссификацию, уменьшить количество приступов и/или снизить тяжесть приступов у субъектов, страдающих прогрессирующей оссифицирующей фибродисплазией.
EA201892497A 2016-06-08 2017-06-08 Способы лечения гетеротопической оссификации EA201892497A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662347381P 2016-06-08 2016-06-08
PCT/CA2017/050701 WO2017210792A1 (en) 2016-06-08 2017-06-08 Methods for treating heterotopic ossification

Publications (1)

Publication Number Publication Date
EA201892497A1 true EA201892497A1 (ru) 2019-05-31

Family

ID=60578331

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892497A EA201892497A1 (ru) 2016-06-08 2017-06-08 Способы лечения гетеротопической оссификации

Country Status (19)

Country Link
US (5) US10864194B2 (ru)
EP (2) EP4249490A3 (ru)
JP (2) JP7023868B2 (ru)
KR (1) KR102486607B1 (ru)
CN (2) CN120204216A (ru)
AU (2) AU2017276835B2 (ru)
BR (1) BR112018075422A2 (ru)
CA (1) CA3025854A1 (ru)
CL (1) CL2018003502A1 (ru)
EA (1) EA201892497A1 (ru)
ES (1) ES2963348T3 (ru)
IL (3) IL317726A (ru)
MX (2) MX390115B (ru)
MY (1) MY200642A (ru)
NZ (1) NZ748939A (ru)
PH (1) PH12018502563A1 (ru)
SG (1) SG11201810658PA (ru)
WO (1) WO2017210792A1 (ru)
ZA (1) ZA201808102B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA026251B1 (ru) 2010-09-01 2017-03-31 Томас Джефферсон Юниверсити Способ восстановления и регенерации мышц
IL317726A (en) * 2016-06-08 2025-02-01 Clementia Pharmaceuticals Inc Methods for treating heterotopic genesis
BR112019009929A2 (pt) * 2016-11-16 2019-08-20 Clementia Pharmaceuticals Inc métodos para inibir a formação de um osteocondroma, para reduzir o tamanho de um osteocondroma, para desacelerar o crescimento de um osteocondroma e para reduzir hiperplasia de cartilagem
WO2020118405A1 (en) * 2018-12-13 2020-06-18 Clementia Pharmaceuticals Inc. Methods for treating heterotopic ossification
WO2021249240A1 (zh) * 2020-06-11 2021-12-16 养生堂有限公司 Palovarotene在抗hbv病毒治疗中的用途
EP4470537A1 (en) * 2023-05-30 2024-12-04 Queen's University At Kingston Compound for use in treating fibrodysplasia ossificans progressiva (fop)
EP4470536A1 (en) * 2023-05-30 2024-12-04 Queen's University At Kingston Compound for use in treating fibrodysplasia ossificans progressiva (fop)

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824685A (en) 1995-02-01 1998-10-20 The Johns Hopkins University School Of Medicine Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists
US5624957A (en) 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
US5919970A (en) 1997-04-24 1999-07-06 Allergan Sales, Inc. Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
US7514074B2 (en) 1997-07-14 2009-04-07 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US6204288B1 (en) 1999-03-08 2001-03-20 The University Of Mississippi 1,2-dithiolane derivatives
US20030114482A1 (en) 1999-12-15 2003-06-19 Maurizio Pacifici Use of retinoid receptor antagonists or agonists in the treatment of cartilage and bone pathologies
US6313168B1 (en) 1999-12-15 2001-11-06 Allergan Sales, Inc. Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies
US20030125252A1 (en) 2000-03-14 2003-07-03 Underhill T. Michael Compositions and methods for affecting osteogenesis
MXPA03002861A (es) 2000-10-02 2003-07-14 Hoffmann La Roche Nuevos retinoides para tratamiento del enfisema.
PL370361A1 (en) 2001-09-18 2005-05-16 F.Hoffmann-La Roche Ag Alkyl urea retinoid agonists i
WO2003024920A1 (en) 2001-09-18 2003-03-27 F. Hoffmann-La Roche Ag Substituted urea retinoid agonists ii
AUPR892501A0 (en) 2001-11-16 2001-12-13 Peter Maccallum Cancer Institute, The Method of enhancing self renewal of stem cells and uses thereof
US20050101581A1 (en) 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
JP2005206544A (ja) 2004-01-23 2005-08-04 Yasuyoshi Uchida 筋肉再生剤
AU2005240078A1 (en) 2004-04-30 2005-11-17 Allergan, Inc. Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing
WO2005115304A2 (en) 2004-05-24 2005-12-08 Ab Science Use of c-kit inhibitors for treating fibrodysplasia
JP2008533165A (ja) 2005-03-17 2008-08-21 エラン ファーマ インターナショナル リミティド ナノ粒子免疫抑制性化合物の注射可能組成物
US7345931B2 (en) 2005-08-01 2008-03-18 Infineon Technologies Ag Maintaining internal voltages of an integrated circuit in response to a clocked standby mode
WO2007037188A1 (ja) 2005-09-27 2007-04-05 Sapporo Medical University 血管透過性亢進に起因する眼疾患の予防及び治療のための医薬
EP1999626A4 (en) 2006-01-26 2009-11-25 Combinatorx Inc METHODS, COMPOSITIONS AND NEEDS FOR TREATING MUSCULOSKELETAL DISORDERS AND SYMPTOMS ASSOCIATED THEREWITH
CA2647275A1 (en) 2006-03-31 2007-10-11 F. Hoffmann-La Roche Ag Process for preparing retinoid compounds
CN101472572B (zh) 2006-05-16 2012-10-10 Io治疗有限责任公司 Rar拮抗剂或反向激动剂在治疗化学疗法和/或放射疗法副作用中的用途
WO2008055072A2 (en) 2006-10-27 2008-05-08 Lpath, Inc. Compositions and methods for treating ocular diseases and conditions
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
WO2009114180A1 (en) * 2008-03-13 2009-09-17 The General Hospital Corporation Inhibitors of the bmp signaling pathway
US8969350B2 (en) 2008-12-18 2015-03-03 Astrazeneca Ab Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient
EP2393915A4 (en) 2009-02-05 2012-12-26 Regenertech Pty Ltd PROCESS FOR THE PREPARATION OF PRECURSOR CELLS FROM DIFFERENTIATED CELLS
WO2011011513A1 (en) * 2009-07-21 2011-01-27 University Of Washington Through Its Center For Commercialization Inhibition of pathological bone formation
EA026251B1 (ru) 2010-09-01 2017-03-31 Томас Джефферсон Юниверсити Способ восстановления и регенерации мышц
JP2013538830A (ja) 2010-09-27 2013-10-17 マイクロドース セラピューテクス，インコーポレイテッド 吸入を用いる疾患治療のための方法及び組成物
WO2012125724A1 (en) 2011-03-14 2012-09-20 Beth Israel Deaconess Medical Center Methods and compositions for the treatment of proliferative disorders
US9464065B2 (en) 2011-03-24 2016-10-11 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
EP2726084A1 (en) * 2011-07-01 2014-05-07 The United States of America, as represented by The Secretary, Department of Health and Human Services Method of treating pathologic heterotopic ossification
JP6302846B2 (ja) 2012-02-22 2018-03-28 サンフォード−バーンハム メディカル リサーチ インスティテュート Ｔｎａｐ阻害剤としてのスルホンアミド化合物およびその使用
AU2013324396B2 (en) 2012-09-28 2018-10-04 Vanderbilt University Fused heterocyclic compounds as selective BMP inhibitors
WO2014073209A1 (ja) 2012-11-08 2014-05-15 国立大学法人山口大学 角結膜障害の治療剤
JP2016510745A (ja) 2013-03-04 2016-04-11 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Ｂｍｐ阻害剤およびその使用方法
US9682983B2 (en) 2013-03-14 2017-06-20 The Brigham And Women's Hospital, Inc. BMP inhibitors and methods of use thereof
PT3000466T (pt) 2013-05-22 2018-11-27 Univ Yamaguchi Inibidor para distúrbios retinocoroidais
US20170305883A1 (en) 2014-10-01 2017-10-26 The Brigham And Women's Hospital, Inc. Compositions and Methods for Inhibiting BMP
WO2017070194A1 (en) 2015-10-19 2017-04-27 The Children's Medical Center Corporation Method to inhibit endothelial-to-mesenchymal transition
US10278982B2 (en) * 2015-12-24 2019-05-07 The Regents Of The University Of Michigan Method of treating heterotopic ossification
IL317726A (en) 2016-06-08 2025-02-01 Clementia Pharmaceuticals Inc Methods for treating heterotopic genesis

Also Published As

Publication number Publication date
US10864194B2 (en) 2020-12-15
US20230285360A1 (en) 2023-09-14
ZA201808102B (en) 2024-04-24
MX2018015108A (es) 2019-08-29
CA3025854A1 (en) 2017-12-14
US20190216781A1 (en) 2019-07-18
CN120204216A (zh) 2025-06-27
US20240277667A1 (en) 2024-08-22
US20210069152A1 (en) 2021-03-11
JP2022019995A (ja) 2022-01-27
WO2017210792A1 (en) 2017-12-14
IL295440A (en) 2022-10-01
EP4249490A2 (en) 2023-09-27
IL317726A (en) 2025-02-01
AU2017276835B2 (en) 2022-03-31
US11622959B2 (en) 2023-04-11
IL263440B (en) 2022-09-01
SG11201810658PA (en) 2018-12-28
IL295440B2 (en) 2025-05-01
JP7023868B2 (ja) 2022-02-22
JP2019517528A (ja) 2019-06-24
KR20190017883A (ko) 2019-02-20
US12138245B2 (en) 2024-11-12
NZ748939A (en) 2025-03-28
AU2022202148B2 (en) 2023-08-24
AU2022202148A1 (en) 2022-04-21
EP3468554B1 (en) 2023-08-09
PH12018502563A1 (en) 2019-10-14
ES2963348T3 (es) 2024-03-26
MX390115B (es) 2025-03-20
CL2018003502A1 (es) 2019-04-26
AU2017276835A1 (en) 2018-12-13
IL263440A (en) 2019-01-31
BR112018075422A2 (pt) 2019-03-12
CN109562099A (zh) 2019-04-02
EP3468554C0 (en) 2023-08-09
MX2022001991A (es) 2022-03-11
KR102486607B1 (ko) 2023-01-11
EP4249490A3 (en) 2023-12-13
US12201614B2 (en) 2025-01-21
EP3468554A1 (en) 2019-04-17
US20240350457A1 (en) 2024-10-24
EP3468554A4 (en) 2020-01-22
IL295440B1 (en) 2025-01-01
MY200642A (en) 2024-01-08

Similar Documents

Publication Publication Date Title
EA201892497A1 (ru) Способы лечения гетеротопической оссификации
CY1125136T1 (el) Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη
CY1125659T1 (el) Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη
CY1124013T1 (el) Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη
CY1122148T1 (el) Συνθεσεις που περιεχουν βακτηριακα στελεχη
CY1122786T1 (el) Δοσολογικα σχηματα για ενωσεις κατηγοριας εχινοκανδινης
CY1123381T1 (el) Συνθεσεις που περιεχουν βακτηριακα στελεχη
EA201890325A1 (ru) Пептидные ингибиторы рецептора интерлейкина-23 и их применение для лечения воспалительных заболеваний
EA201891199A1 (ru) Композиции, содержащие бактериальные штаммы
EA201692201A1 (ru) Соединения и композиции в качестве агонистов toll-подобного рецептора 7
EA201890048A1 (ru) Композиции, содержащие бактериальные штаммы
EA201692177A1 (ru) Соединения и композиции в качестве агонистов toll-подобного рецептора 7
NZ737399A (en) Ccr2 modulators
CY1125150T1 (el) Ενωσεις φαινυλο-2-υδροξυ-ακετυλαμινο-2-μεθυλο-φαινυλιου
EA201791454A1 (ru) Лекарственные формы для трансдермального введения
EA202192625A1 (ru) Лиганды псевдокиназы tyk2
CY1126031T1 (el) Συνθεσεις για καθαρισμο του παχεος εντερου και την αντιμετωπιση γαστρεντερικων διαταραχων
EA201791401A1 (ru) СПОСОБ ТЕРАПЕВТИЧЕСКОГО ЛЕЧЕНИЯ СИНДРОМА РАЗДРАЖЁННОГО КИШЕЧНИКА С ПРЕОБЛАДАНИЕМ ДИАРЕИ С ПРИМЕНЕНИЕМ Bacillus coagulans SBC37-01, MTCC 5856
EA201790893A1 (ru) Способы лечения офтальмологических расстройств
EA201792571A1 (ru) Терапевтическое применение l-4-хлорокинуренина
EA201791937A1 (ru) Противовоспалительные полипептиды
EA201791450A1 (ru) 3,5-диаминопиразоловые ингибиторы киназы
EA202191927A1 (ru) Модуляторы gpr35
EA201992647A1 (ru) Композиции, содержащие бактериальные штаммы
EA201992214A2 (ru) Фармацевтические композиции леветирацетама пролонгированного высвобождения