EA201791233A1 - Материал стволовых клеток и способ его получения - Google Patents
Материал стволовых клеток и способ его полученияInfo
- Publication number
- EA201791233A1 EA201791233A1 EA201791233A EA201791233A EA201791233A1 EA 201791233 A1 EA201791233 A1 EA 201791233A1 EA 201791233 A EA201791233 A EA 201791233A EA 201791233 A EA201791233 A EA 201791233A EA 201791233 A1 EA201791233 A1 EA 201791233A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- msc
- stem cell
- conditioned
- preparation
- cell material
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 230000001143 conditioned effect Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003636 conditioned culture medium Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/185—Osteoprotegerin; Osteoclast differentiation factor (ODF, RANKL)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
Abstract
Аспекты настоящего изобретения относятся к новой линии мезенхимальных стволовых клеток (hb-MSC), культуральной среде, кондиционированной линией hb-MSC, и различным композициям hb-MSC. Композиция hb-MSC может включать множество hb-MSC, среду, кондиционированную hb-MSC, или их комбинацию. Композиция hb-MSC может также включать приемлемый носитель. Также описаны способы применения клеток hb-MSC, кондиционированной среды и их композиций.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2014148251A RU2644650C2 (ru) | 2014-12-01 | 2014-12-01 | Материал стволовых клеток и способ его получения |
PCT/RU2015/000831 WO2016089252A1 (en) | 2014-12-01 | 2015-11-30 | Stem cell material and method of manufacturing |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201791233A1 true EA201791233A1 (ru) | 2017-09-29 |
Family
ID=56092075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791233A EA201791233A1 (ru) | 2014-12-01 | 2015-11-30 | Материал стволовых клеток и способ его получения |
Country Status (9)
Country | Link |
---|---|
US (2) | US10744160B2 (ru) |
EP (1) | EP3226876B1 (ru) |
JP (2) | JP7097698B2 (ru) |
KR (2) | KR102257386B1 (ru) |
CN (1) | CN107429228B (ru) |
EA (1) | EA201791233A1 (ru) |
IL (1) | IL252529B (ru) |
RU (1) | RU2644650C2 (ru) |
WO (1) | WO2016089252A1 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2708329C2 (ru) | 2016-05-31 | 2019-12-05 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток, композиции и способы применения |
MY196026A (en) * | 2017-02-16 | 2023-03-07 | Oct Therapies And Res Private Limited | Stem Cell Conditioned Media for Clinical and Cosmetic Applications |
KR101999818B1 (ko) * | 2017-07-26 | 2019-07-12 | ㈜로제타엑소좀 | 소수성 상호작용을 이용한 세포밖 소포체의 분리방법 |
CN108753684A (zh) * | 2018-06-19 | 2018-11-06 | 山东信得科技股份有限公司 | 一种去除pk15细胞中支原体的方法 |
AU2020315475A1 (en) | 2019-07-18 | 2022-02-03 | Direct Biologics Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
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ITMI20120338A1 (it) | 2012-03-06 | 2013-09-07 | Dr Andrea Bignotti | Preparato terapeutico e procedimento di preparazione di detto preparato terapeutico |
RU2512681C2 (ru) | 2012-08-22 | 2014-04-10 | Антонина Ивановна Колесникова | Способ лечения длительно незаживающей раны и/или раневой полости |
MX2015002711A (es) * | 2012-09-04 | 2015-06-05 | Anthrogenesis Corp | Metodos de generacion de tejidos. |
ITTO20120859A1 (it) * | 2012-10-02 | 2014-04-03 | Univ Degli Studi Torino | Nuova applicazione terapeutica di un mezzo condizionato da cellule staminali mesenchimali placentari |
WO2015028900A1 (en) | 2013-08-29 | 2015-03-05 | Stempeutics Research Pvt. Ltd. | Stromal cells derived conditioned medium, method of obtaining said conditioned medium compositions, formulations and applications thereof |
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2014
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2015
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EP3226876A4 (en) | 2017-10-11 |
US10744160B2 (en) | 2020-08-18 |
IL252529A0 (en) | 2017-07-31 |
KR20210084527A (ko) | 2021-07-07 |
IL252529B (en) | 2021-08-31 |
JP7116501B2 (ja) | 2022-08-10 |
RU2014148251A (ru) | 2016-06-27 |
KR20170089924A (ko) | 2017-08-04 |
EP3226876B1 (en) | 2023-11-01 |
RU2644650C2 (ru) | 2018-02-13 |
RU2017123284A3 (ru) | 2019-06-24 |
WO2016089252A1 (en) | 2016-06-09 |
EP3226876A1 (en) | 2017-10-11 |
JP7097698B2 (ja) | 2022-07-08 |
US20200360443A1 (en) | 2020-11-19 |
CN107429228B (zh) | 2024-04-05 |
KR102257386B1 (ko) | 2021-05-27 |
JP2017536849A (ja) | 2017-12-14 |
US20170326178A1 (en) | 2017-11-16 |
RU2017123284A (ru) | 2019-01-09 |
CN107429228A (zh) | 2017-12-01 |
JP2021072789A (ja) | 2021-05-13 |
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