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EA201592143A1 - Новые бициклические ингибиторы бромодомена - Google Patents

Новые бициклические ингибиторы бромодомена

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Publication number
EA201592143A1
EA201592143A1 EA201592143A EA201592143A EA201592143A1 EA 201592143 A1 EA201592143 A1 EA 201592143A1 EA 201592143 A EA201592143 A EA 201592143A EA 201592143 A EA201592143 A EA 201592143A EA 201592143 A1 EA201592143 A1 EA 201592143A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bromodomene
new bicyclic
inhibitors
bicyclic inhibitors
extraterminal
Prior art date
Application number
EA201592143A
Other languages
English (en)
Other versions
EA035601B1 (ru
Inventor
Джон Фредерик Квинн
Жуйфан Ван
Мэй Сяову Цзян
Грегори Скотт Мартин
Грегори Стивен Вагнер
Питер Роналд Ян
Брайан Корделл Даффи
Шуан Лю
Original Assignee
Зенит Эпидженетикс Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зенит Эпидженетикс Корп. filed Critical Зенит Эпидженетикс Корп.
Publication of EA201592143A1 publication Critical patent/EA201592143A1/ru
Publication of EA035601B1 publication Critical patent/EA035601B1/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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Abstract

Данное изобретение относится к новым замещенным, бициклическим соединениям, которые применяют в качестве ингибиторов функции экстратерминальных белков BET посредством связывания с бромодоменами. Фармацевтические композиции, содержащие такие соединения, служат для профилактики и лечения заболеваний и состояний, которые связаны с бромодоменом и экстратерминальными белками (BET).
EA201592143A 2013-06-21 2014-06-20 Бициклические ингибиторы бромодомена EA035601B1 (ru)

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PCT/US2014/043423 WO2015002754A2 (en) 2013-06-21 2014-06-20 Novel bicyclic bromodomain inhibitors

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