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EA201591648A1 - Бензимидазол-2-ил-пиримидиновые модуляторы рецептора гистамина h4 - Google Patents

Бензимидазол-2-ил-пиримидиновые модуляторы рецептора гистамина h4

Info

Publication number
EA201591648A1
EA201591648A1 EA201591648A EA201591648A EA201591648A1 EA 201591648 A1 EA201591648 A1 EA 201591648A1 EA 201591648 A EA201591648 A EA 201591648A EA 201591648 A EA201591648 A EA 201591648A EA 201591648 A1 EA201591648 A1 EA 201591648A1
Authority
EA
Eurasian Patent Office
Prior art keywords
histamine
receptor
benzimidazol
modulators
pyrimidine
Prior art date
Application number
EA201591648A
Other languages
English (en)
Inventor
Магали Б. Хики
Штефан Хорнс
Зузанне Лохнер
Маттео Конца
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201591648A1 publication Critical patent/EA201591648A1/ru

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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Abstract

Бензимидазол-2-ил-пиримидины, способы их очистки и фармацевтические композиции и способы лечения болезней, расстройств и состояний, опосредованных активностью рецептора гистамина Н, включая аллергию, астму, аутоиммунные заболевания и зуд.
EA201591648A 2013-03-06 2014-03-06 Бензимидазол-2-ил-пиримидиновые модуляторы рецептора гистамина h4 EA201591648A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361773706P 2013-03-06 2013-03-06
US201361776260P 2013-03-11 2013-03-11
US201361784909P 2013-03-14 2013-03-14
PCT/US2014/021130 WO2014138368A1 (en) 2013-03-06 2014-03-06 Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor

Publications (1)

Publication Number Publication Date
EA201591648A1 true EA201591648A1 (ru) 2016-02-29

Family

ID=51488591

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591648A EA201591648A1 (ru) 2013-03-06 2014-03-06 Бензимидазол-2-ил-пиримидиновые модуляторы рецептора гистамина h4

Country Status (38)

Country Link
US (4) US8859575B2 (ru)
EP (2) EP3660011A1 (ru)
JP (1) JP6471103B2 (ru)
KR (1) KR102230383B1 (ru)
CN (1) CN105025898B (ru)
AU (1) AU2014225675B2 (ru)
BR (1) BR112015021463A8 (ru)
CA (1) CA2903737C (ru)
CL (1) CL2015002434A1 (ru)
CR (1) CR20150435A (ru)
CY (1) CY1122545T1 (ru)
DK (1) DK2964229T3 (ru)
DO (1) DOP2016000027A (ru)
EA (1) EA201591648A1 (ru)
ES (1) ES2773543T3 (ru)
GT (1) GT201500243A (ru)
HR (1) HRP20200253T1 (ru)
HU (1) HUE047681T2 (ru)
IL (1) IL240247B (ru)
JO (1) JO3516B1 (ru)
LT (1) LT2964229T (ru)
MX (1) MX373874B (ru)
MY (1) MY180726A (ru)
NZ (1) NZ710640A (ru)
PE (1) PE20151536A1 (ru)
PH (1) PH12015501731A1 (ru)
PL (1) PL2964229T3 (ru)
PT (1) PT2964229T (ru)
RS (1) RS59909B1 (ru)
SA (1) SA515360981B1 (ru)
SG (1) SG11201507117XA (ru)
SI (1) SI2964229T1 (ru)
SM (1) SMT202000084T1 (ru)
TW (1) TWI617554B (ru)
UA (1) UA118754C2 (ru)
UY (1) UY35370A (ru)
WO (1) WO2014138368A1 (ru)
ZA (1) ZA201507351B (ru)

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PL2007752T3 (pl) 2006-03-31 2011-02-28 Janssen Pharmaceutica Nv Benzoimidazol-2-ilopirymidyny i pirazyny jako modulatory receptora histaminowego H4
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
HUE047681T2 (hu) 2013-03-06 2020-05-28 Janssen Pharmaceutica Nv A hisztamin H4 receptor benzimidazol-2-il-pirimidin modulátorai
JO3509B1 (ar) 2013-03-14 2020-07-05 Janssen Pharmaceutica Nv معدلات p2x7
JP6467404B2 (ja) 2013-03-14 2019-02-13 ヤンセン ファーマシューティカ エヌ．ベー． Ｐ２ｘ７モジュレーター
TWI599567B (zh) 2013-03-14 2017-09-21 健生藥品公司 Ｐ２ｘ７調節劑
WO2014152589A1 (en) 2013-03-14 2014-09-25 Janssen Pharmaceutica Nv P2x7 modulators
JP6592510B2 (ja) 2014-09-12 2019-10-16 ヤンセン ファーマシューティカ エヌ．ベー． Ｐ２ｘ７調節因子
EP3191488B1 (en) 2014-09-12 2019-08-14 Janssen Pharmaceutica NV P2x7 modulating n-acyl-triazolopyrazines
EP3533451B1 (en) 2017-01-21 2022-07-27 Guangzhou Hanfang Pharmaceuticals Co., Ltd. Application of paeoniflorin-6'-o-benzene sulfonate in medicine for treating sjögren's syndrome
TW202035409A (zh) 2018-09-28 2020-10-01 比利時商健生藥品公司 單醯基甘油脂肪酶調節劑
JOP20210058A1 (ar) 2018-09-28 2021-03-24 Janssen Pharmaceutica Nv مُعدلات ليباز أُحادِيُّ الجلِيسِريد
AU2020358948A1 (en) 2019-09-30 2022-05-26 Janssen Pharmaceutica Nv Radiolabelled MGL PET ligands
CN115335378B (zh) 2020-03-26 2025-03-04 詹森药业有限公司 单酰基甘油脂肪酶调节剂

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