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EA201490393A1 - Соматотропный гормон пролонгированного действия и способы его получения - Google Patents

Соматотропный гормон пролонгированного действия и способы его получения

Info

Publication number
EA201490393A1
EA201490393A1 EA201490393A EA201490393A EA201490393A1 EA 201490393 A1 EA201490393 A1 EA 201490393A1 EA 201490393 A EA201490393 A EA 201490393A EA 201490393 A EA201490393 A EA 201490393A EA 201490393 A1 EA201490393 A1 EA 201490393A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
somatotropic hormone
hormone
somatotropic
body fat
Prior art date
Application number
EA201490393A
Other languages
English (en)
Other versions
EA035352B1 (ru
Inventor
Фуад Фарес
Уди Эйял Фима
Original Assignee
Опко Байолоджикс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Опко Байолоджикс Лтд. filed Critical Опко Байолоджикс Лтд.
Publication of EA201490393A1 publication Critical patent/EA201490393A1/ru
Publication of EA035352B1 publication Critical patent/EA035352B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Раскрывается использование белка соматотропного гормона и полинуклеотидов, кодирующих его, что включает аминоконцевой и карбоксиконцевой пептид (СТР) хорионического гонадотропина и два карбоксиконцевых СТР хорионического гонадотропина, присоединенных к соматотропному гормону, в способах стимулирования потери веса или снижения телесного жира, способах увеличения уровней инсулиноподобного ростового фактора (IGF-1) и способах снижения частоты приема соматотропного гормона у человека. Также раскрываются фармацевтические композиции, содержащие соматотропный гормон и полинуклеотиды, кодирующие соматотропный гормон изобретения, и способы их применения.
EA201490393A 2011-08-02 2012-08-02 Способ лечения дефицита соматотропного гормона EA035352B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/195,931 US8450269B2 (en) 2006-02-03 2011-08-02 Long-acting growth hormone and methods of producing same
PCT/IL2012/050288 WO2013018098A2 (en) 2011-08-02 2012-08-02 Long-acting growth hormone and methods of producing same

Publications (2)

Publication Number Publication Date
EA201490393A1 true EA201490393A1 (ru) 2015-01-30
EA035352B1 EA035352B1 (ru) 2020-06-01

Family

ID=47629749

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201490393A EA035352B1 (ru) 2011-08-02 2012-08-02 Способ лечения дефицита соматотропного гормона
EA202090577A EA202090577A3 (ru) 2011-08-02 2012-08-02 Соматотропный гормон пролонгированного действия и способы его получения

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202090577A EA202090577A3 (ru) 2011-08-02 2012-08-02 Соматотропный гормон пролонгированного действия и способы его получения

Country Status (23)

Country Link
US (1) US8450269B2 (ru)
EP (2) EP2739298B1 (ru)
JP (1) JP6153930B2 (ru)
KR (3) KR102028524B1 (ru)
CN (2) CN107080835A (ru)
AU (1) AU2012291617B2 (ru)
BR (1) BR112014002491A2 (ru)
CA (1) CA2843672A1 (ru)
CL (2) CL2014000254A1 (ru)
CO (1) CO7020850A2 (ru)
DK (2) DK3482765T5 (ru)
EA (2) EA035352B1 (ru)
ES (2) ES2706734T3 (ru)
FI (1) FI3482765T3 (ru)
HK (1) HK1200349A1 (ru)
HR (1) HRP20240635T1 (ru)
HU (2) HUE066552T2 (ru)
MX (2) MX360802B (ru)
PL (2) PL3482765T3 (ru)
PT (2) PT2739298T (ru)
SI (2) SI2739298T1 (ru)
TR (1) TR201821186T4 (ru)
WO (1) WO2013018098A2 (ru)

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