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EA201391202A1 - Способ получения множественных антигенных гликопептид-углеводных конъюгатов - Google Patents

Способ получения множественных антигенных гликопептид-углеводных конъюгатов

Info

Publication number
EA201391202A1
EA201391202A1 EA201391202A EA201391202A EA201391202A1 EA 201391202 A1 EA201391202 A1 EA 201391202A1 EA 201391202 A EA201391202 A EA 201391202A EA 201391202 A EA201391202 A EA 201391202A EA 201391202 A1 EA201391202 A1 EA 201391202A1
Authority
EA
Eurasian Patent Office
Prior art keywords
glykopeptid
antigene
preparing multiple
conjugates
carbon
Prior art date
Application number
EA201391202A
Other languages
English (en)
Inventor
Сильви Бай
Клод Леклерк
Ришар Ло-Ман
Original Assignee
Инститют Пастер
Сентр Насьональ Де Ля Решерш Сьянтифик
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Инститют Пастер, Сентр Насьональ Де Ля Решерш Сьянтифик filed Critical Инститют Пастер
Publication of EA201391202A1 publication Critical patent/EA201391202A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Container Filling Or Packaging Operations (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Изобретение относится к способу получения углеводных конъюгатов T-клеточных эпитопов формулы (I)где M, T, B и n являются такими, как определено в п.1 формулы изобретения.
EA201391202A 2011-03-17 2012-03-16 Способ получения множественных антигенных гликопептид-углеводных конъюгатов EA201391202A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11290138A EP2500033A1 (en) 2011-03-17 2011-03-17 Method for preparing muliple antigen glycopeptide carbohydrate conjugates
PCT/IB2012/051285 WO2012123926A1 (en) 2011-03-17 2012-03-16 Method for preparing multiple antigen glycopeptide carbohydrate conjugates

Publications (1)

Publication Number Publication Date
EA201391202A1 true EA201391202A1 (ru) 2014-03-31

Family

ID=44512239

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391202A EA201391202A1 (ru) 2011-03-17 2012-03-16 Способ получения множественных антигенных гликопептид-углеводных конъюгатов

Country Status (16)

Country Link
US (2) US20140378652A9 (ru)
EP (2) EP2500033A1 (ru)
JP (1) JP6006244B2 (ru)
KR (1) KR20140048107A (ru)
CN (1) CN103732246B (ru)
AU (1) AU2012227940A1 (ru)
BR (1) BR112013023599B1 (ru)
CA (1) CA2828688C (ru)
DK (1) DK2686009T3 (ru)
EA (1) EA201391202A1 (ru)
ES (1) ES2537180T3 (ru)
IL (1) IL228384A0 (ru)
MX (1) MX354325B (ru)
SG (1) SG193433A1 (ru)
WO (1) WO2012123926A1 (ru)
ZA (1) ZA201306219B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3410849B1 (en) 2016-02-05 2023-07-05 Institut Pasteur Use of inhibitors of adam12 as adjuvants in tumor therapies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL105503A (en) 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
US6410690B1 (en) * 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
AU6832398A (en) 1997-03-27 1998-10-22 Institut Pasteur Multiple antigen glycopeptide carbohydrate, vaccine comprising the same and use thereof
US6676946B2 (en) * 1997-03-27 2004-01-13 Institut Pasteur Multiple antigen glycopeptide carbohydrate vaccine comprising the same and use thereof
CA2286798C (en) * 1997-04-16 2014-01-07 Sloan-Kettering Institute For Cancer Research Alpha-o-linked glycoconjugates with clustered(2,6)-st epitopes, methods of preparation and uses thereof

Also Published As

Publication number Publication date
MX354325B (es) 2018-02-26
MX2013010618A (es) 2014-04-14
EP2500033A1 (en) 2012-09-19
US10899799B2 (en) 2021-01-26
KR20140048107A (ko) 2014-04-23
JP6006244B2 (ja) 2016-10-12
AU2012227940A1 (en) 2013-09-05
WO2012123926A1 (en) 2012-09-20
BR112013023599B1 (pt) 2023-01-10
IL228384A0 (en) 2013-12-31
EP2686009B1 (en) 2015-04-29
EP2686009A1 (en) 2014-01-22
DK2686009T3 (da) 2015-06-15
SG193433A1 (en) 2013-10-30
US20140378652A9 (en) 2014-12-25
CA2828688C (en) 2021-08-03
JP2014510083A (ja) 2014-04-24
ZA201306219B (en) 2014-05-28
CN103732246B (zh) 2017-06-30
US20170283466A1 (en) 2017-10-05
ES2537180T3 (es) 2015-06-03
CA2828688A1 (en) 2012-09-20
BR112013023599A2 (pt) 2019-05-07
US20140171618A1 (en) 2014-06-19
CN103732246A (zh) 2014-04-16

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