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EA201290808A1 - Замещенные конденсированные производные имидазола, фармацевтические композиции и способы их применения - Google Patents

Замещенные конденсированные производные имидазола, фармацевтические композиции и способы их применения

Info

Publication number
EA201290808A1
EA201290808A1 EA201290808A EA201290808A EA201290808A1 EA 201290808 A1 EA201290808 A1 EA 201290808A1 EA 201290808 A EA201290808 A EA 201290808A EA 201290808 A EA201290808 A EA 201290808A EA 201290808 A1 EA201290808 A1 EA 201290808A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
substituted condensed
pharmaceutical compositions
imidazol
condensed derivatives
Prior art date
Application number
EA201290808A
Other languages
English (en)
Inventor
Аднан М.М. Мджалли
Дхарма Рао Полисетти
Джарир Набил Касис
Мэттью Дж. Костура
Мустафа Гузель
Отис Клинтон Эттакс
Роберт Карл Эндрюс
Сэмьюэл Виктори
Супарна Гупта
Original Assignee
ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи filed Critical ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
Publication of EA201290808A1 publication Critical patent/EA201290808A1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

Предложены замещенные конденсированные производные имидазолов, способы их получения, фармацевтические композиции, включающие замещенные конденсированные производные имидазолов, и способы их применения при лечении воспалений. Замещенные конденсированные производные имидазолов могут контролировать активность или количество, или активность и количество гемоксигеназы.
EA201290808A 2010-02-18 2011-02-10 Замещенные конденсированные производные имидазола, фармацевтические композиции и способы их применения EA201290808A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30572410P 2010-02-18 2010-02-18
JOP20110047 2011-02-03
PCT/US2011/024311 WO2011103018A1 (en) 2010-02-18 2011-02-10 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof

Publications (1)

Publication Number Publication Date
EA201290808A1 true EA201290808A1 (ru) 2013-03-29

Family

ID=62839064

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Application Number Title Priority Date Filing Date
EA201290808A EA201290808A1 (ru) 2010-02-18 2011-02-10 Замещенные конденсированные производные имидазола, фармацевтические композиции и способы их применения

Country Status (14)

Country Link
US (1) US12091407B2 (ru)
EP (1) EP2536285B1 (ru)
JP (1) JP5814948B2 (ru)
KR (1) KR101837759B1 (ru)
CN (1) CN102762101B (ru)
AU (1) AU2011218316B2 (ru)
CA (1) CA2789950C (ru)
DK (1) DK2536285T3 (ru)
EA (1) EA201290808A1 (ru)
ES (1) ES2679918T3 (ru)
MX (1) MX339243B (ru)
NZ (1) NZ602395A (ru)
SG (1) SG182629A1 (ru)
WO (1) WO2011103018A1 (ru)

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