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EA201270556A1 - Конденсированные тиазоло и оксазолопиримидиноны - Google Patents

Конденсированные тиазоло и оксазолопиримидиноны

Info

Publication number
EA201270556A1
EA201270556A1 EA201270556A EA201270556A EA201270556A1 EA 201270556 A1 EA201270556 A1 EA 201270556A1 EA 201270556 A EA201270556 A EA 201270556A EA 201270556 A EA201270556 A EA 201270556A EA 201270556 A1 EA201270556 A1 EA 201270556A1
Authority
EA
Eurasian Patent Office
Prior art keywords
тиазоло
оксазолопиримидиноны
конденсированные
present
compounds
Prior art date
Application number
EA201270556A
Other languages
English (en)
Other versions
EA020228B1 (ru
Inventor
Санджай Сривастава
Лаксмикант Чххипа
Рамеш Чхандра Гупта
Шайлеш Дешпанде
Анита Чхаудхари
Аноокх Моханан
Чхайтанья Дутт
Виджай Чхаутхайвале
Мурали Бадантхадка
Прашант Г. Джамадаркхана
Original Assignee
Торрент Фармасьютикалз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Торрент Фармасьютикалз Лимитед filed Critical Торрент Фармасьютикалз Лимитед
Publication of EA201270556A1 publication Critical patent/EA201270556A1/ru
Publication of EA020228B1 publication Critical patent/EA020228B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым соединениям, их фармацевтически приемлемым солям и их изомерам, стереоизомерам, конформерам, таутомерам, полиморфам, гидратам и сольватам. Настоящее изобретение также включает фармацевтически приемлемые композиции указанных соединений и способ приготовления новых соединений. Настоящее изобретение кроме того относится к применению вышеупомянутых соединений для приготовления лекарственного препарата для применения в качестве лекарственного средства.
EA201270556A 2009-10-13 2010-08-31 Конденсированные тиазоло- и оксазолопиримидиноны EA020228B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1249KO2009 2009-10-13
PCT/IN2010/000579 WO2011045811A1 (en) 2009-10-13 2010-08-31 Fused thiazolo and oxazolo pyrimidinones

Publications (2)

Publication Number Publication Date
EA201270556A1 true EA201270556A1 (ru) 2013-01-30
EA020228B1 EA020228B1 (ru) 2014-09-30

Family

ID=43034589

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270556A EA020228B1 (ru) 2009-10-13 2010-08-31 Конденсированные тиазоло- и оксазолопиримидиноны

Country Status (29)

Country Link
EP (1) EP2385948B1 (ru)
JP (1) JP5681195B2 (ru)
KR (1) KR101710430B1 (ru)
CN (1) CN102549000B (ru)
AR (1) AR080616A1 (ru)
AU (1) AU2010307984B2 (ru)
BR (1) BR112012006233B8 (ru)
CA (1) CA2772995C (ru)
CY (1) CY1119710T1 (ru)
DK (1) DK2385948T3 (ru)
EA (1) EA020228B1 (ru)
ES (1) ES2653931T3 (ru)
HR (1) HRP20171976T1 (ru)
HU (1) HUE038051T2 (ru)
IL (1) IL219116A (ru)
LT (1) LT2385948T (ru)
MX (1) MX2012004074A (ru)
MY (1) MY157629A (ru)
NO (1) NO2385948T3 (ru)
NZ (1) NZ598020A (ru)
PH (1) PH12012500704A1 (ru)
PL (1) PL2385948T3 (ru)
RS (1) RS56630B1 (ru)
SI (1) SI2385948T1 (ru)
SM (1) SMT201700584T1 (ru)
TW (1) TWI500623B (ru)
UA (1) UA107473C2 (ru)
WO (1) WO2011045811A1 (ru)
ZA (1) ZA201203262B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI661828B (zh) 2013-05-14 2019-06-11 印度商托仁特生技有限公司 低劑量藥物組合物及其用途
AU2015311333B2 (en) 2014-09-02 2017-11-16 Sunshine Lake Pharma Co., Ltd. Quinolinone compound and use thereof
CN106905348B (zh) * 2017-02-13 2018-12-04 牡丹江医学院 一种预防和治疗急性肾损伤的药物及其制备方法和用途
CN110511233B (zh) * 2019-08-08 2022-01-25 成都大学 一种噻唑并[2,3-b]噁唑酮类化合物及其制备方法和用途
CN112778333B (zh) * 2021-01-23 2022-07-05 中国科学院新疆理化技术研究所 一种四氢噁唑并吡啶并氮氧杂酮类衍生物及其用途
WO2024220635A1 (en) * 2023-04-18 2024-10-24 Vanderbilt University Thiazolopyridine derivatives as positive allosteric modulators of the muscarinic acetylcholine receptor m4

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072679A (en) * 1976-06-15 1978-02-07 E. R. Squibb & Sons, Inc. 1,4- AND 4,10-DIHYDRO-4-OXO-PYRIMIDO (1,2-A)-benzimidazole-3-carboxylic acids, esters and amides
US4423048A (en) 1979-11-23 1983-12-27 Pfizer Inc. Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor
DK151811C (da) * 1979-11-23 1988-06-06 Pfizer Analogifremgangsmaade til fremstilling af n-(5-tetrazolyl)-1-oxo-1h-thiazolooe3,2-aaa-pyrimidin-2-carboxamider eller farmaceutisk acceptable kationsalte deraf samt 1-oxo-1h-thiazolooe3,2-aaapyrimidin-2-carboxylsyrer til anvendelse som udgangsmaterialer ved fremgangsmaaden
JPH0539293A (ja) * 1991-01-23 1993-02-19 Kyowa Hakko Kogyo Co Ltd 免疫調節剤及びチアゾロピリミジン誘導体
CA2138929A1 (en) 1993-12-30 1995-07-01 Klaus Weidmann Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals
CA2467689C (en) 2001-12-06 2013-10-01 Fibrogen, Inc. Stabilization of hypoxia inducible factor (hif) alpha using inhibitors of hif prolyl hydroxylase
PL377550A1 (pl) 2002-12-25 2006-02-06 Daiichi Pharmaceutical Co., Ltd. Pochodne diamin
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
BRPI0710527B8 (pt) * 2006-04-04 2021-05-25 Fibrogen Inc compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende
US7713986B2 (en) 2006-06-15 2010-05-11 Fibrogen, Inc. Compounds and methods for treatment of chemotherapy-induced anemia
US20070293575A1 (en) 2006-06-15 2007-12-20 Fibrogen, Inc. Compounds and methods for treatment of cancer-related anemia
JO2934B1 (en) * 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
WO2009039321A1 (en) * 2007-09-19 2009-03-26 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009039322A1 (en) * 2007-09-19 2009-03-26 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors

Also Published As

Publication number Publication date
CN102549000B (zh) 2015-12-02
AU2010307984B2 (en) 2013-11-07
ZA201203262B (en) 2013-01-30
BR112012006233B8 (pt) 2021-05-25
SI2385948T1 (en) 2018-04-30
JP5681195B2 (ja) 2015-03-04
EP2385948A1 (en) 2011-11-16
CA2772995A1 (en) 2011-04-21
MY157629A (en) 2016-07-15
DK2385948T3 (en) 2017-12-04
KR20120093907A (ko) 2012-08-23
IL219116A0 (en) 2012-06-28
TWI500623B (zh) 2015-09-21
PL2385948T3 (pl) 2018-02-28
AR080616A1 (es) 2012-04-25
BR112012006233B1 (pt) 2021-05-18
HRP20171976T1 (hr) 2018-02-09
HUE038051T2 (hu) 2018-10-29
WO2011045811A1 (en) 2011-04-21
LT2385948T (lt) 2018-01-10
SMT201700584T1 (it) 2018-01-11
ES2653931T3 (es) 2018-02-09
NO2385948T3 (ru) 2018-03-03
CN102549000A (zh) 2012-07-04
EP2385948B1 (en) 2017-10-04
PH12012500704A1 (en) 2012-10-29
BR112012006233A2 (pt) 2020-08-11
EA020228B1 (ru) 2014-09-30
JP2013507435A (ja) 2013-03-04
CY1119710T1 (el) 2018-06-27
TW201113290A (en) 2011-04-16
IL219116A (en) 2016-05-31
NZ598020A (en) 2013-11-29
CA2772995C (en) 2018-03-13
RS56630B1 (sr) 2018-03-30
MX2012004074A (es) 2012-05-22
UA107473C2 (ru) 2015-01-12
AU2010307984A1 (en) 2012-03-01
KR101710430B1 (ko) 2017-02-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM