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EA201201114A1 - Агонистические dr5-связывающие полипептиды - Google Patents

Агонистические dr5-связывающие полипептиды

Info

Publication number
EA201201114A1
EA201201114A1 EA201201114A EA201201114A EA201201114A1 EA 201201114 A1 EA201201114 A1 EA 201201114A1 EA 201201114 A EA201201114 A EA 201201114A EA 201201114 A EA201201114 A EA 201201114A EA 201201114 A1 EA201201114 A1 EA 201201114A1
Authority
EA
Eurasian Patent Office
Prior art keywords
agonistic
binding polypeptides
polypeptides
disorders
fragments
Prior art date
Application number
EA201201114A
Other languages
English (en)
Inventor
Карен Кроми
Брюно Домбрехт
Сет Эттенберг
Йост Колкман
Цзин Ли
Крис Мерсарт
Дейвид Раймонд Стоувер
Цзинсинь Чжан
Original Assignee
Новартис Аг
Аблинкс Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43877025&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201201114(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг, Аблинкс Нв filed Critical Новартис Аг
Publication of EA201201114A1 publication Critical patent/EA201201114A1/ru

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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Abstract

В заявке описаны аминокислотные последовательности, мишенью которых является расположенный на клеточной поверхности рецептор 2 TRAIL (обозначенный в описании как DR5), а также содержащие их соединения и конструкции, прежде всего белки и полипептиды, и кодирующие их нуклеотиды (обозначенные в описании в целом как "NB-агенты") и их фрагменты, и их фармацевтически эффективные варианты, и их применение для диагностирования и лечения ассоциированных с DR5 заболеваний и нарушений.
EA201201114A 2010-02-10 2011-02-10 Агонистические dr5-связывающие полипептиды EA201201114A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30317310P 2010-02-10 2010-02-10
US30859910P 2010-02-26 2010-02-26
PCT/EP2011/051958 WO2011098520A1 (en) 2010-02-10 2011-02-10 Agonist dr5 binding polypeptides

Publications (1)

Publication Number Publication Date
EA201201114A1 true EA201201114A1 (ru) 2013-03-29

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ID=43877025

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EA201201114A EA201201114A1 (ru) 2010-02-10 2011-02-10 Агонистические dr5-связывающие полипептиды

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US (2) US9120855B2 (ru)
EP (1) EP2534176A1 (ru)
JP (1) JP2013519364A (ru)
KR (1) KR20130031241A (ru)
CN (1) CN102884083A (ru)
AR (1) AR080158A1 (ru)
AU (1) AU2011214355B2 (ru)
BR (1) BR112012019924A2 (ru)
CA (1) CA2789251A1 (ru)
CL (1) CL2012002217A1 (ru)
CO (1) CO6561836A2 (ru)
CR (1) CR20120415A (ru)
CU (1) CU24133B1 (ru)
EA (1) EA201201114A1 (ru)
GE (1) GEP20146176B (ru)
GT (1) GT201200236A (ru)
IL (1) IL221289A0 (ru)
MA (1) MA34053B1 (ru)
MX (1) MX2012009328A (ru)
MY (1) MY156337A (ru)
NI (1) NI201200134A (ru)
NZ (1) NZ601582A (ru)
PE (1) PE20121703A1 (ru)
PH (1) PH12012501613A1 (ru)
SG (1) SG183210A1 (ru)
TN (1) TN2012000393A1 (ru)
TW (1) TWI480051B (ru)
UA (1) UA106900C2 (ru)
UY (1) UY33222A (ru)
WO (1) WO2011098520A1 (ru)
ZA (1) ZA201205864B (ru)

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ES2644022T3 (es) 2013-03-14 2017-11-27 Bristol-Myers Squibb Company Combinación de un agonista de DR5 y un antagonista de anti-PD-1 y métodos de uso
UA118028C2 (uk) 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
WO2015100409A2 (en) * 2013-12-26 2015-07-02 Tufts University Methods, compositions and kits for treating a subject using a recombinant neutralizing binding protein
WO2015104994A1 (ja) * 2014-01-10 2015-07-16 学校法人帝京平成大学 組換え偏性嫌気性グラム陽性菌
EP3250601A4 (en) 2015-01-26 2018-07-11 MacroGenics, Inc. Multivalent molecules comprising dr5-binding domains
CN104826121A (zh) * 2015-02-11 2015-08-12 嘉兴学院 肿瘤靶向基因递送系统及其应用
PT3322734T (pt) * 2015-07-16 2020-11-30 Inhibrx Inc Proteínas de fusão de ligação a dr5 multivalentes e multispecíficas
CN109195626B (zh) * 2015-10-30 2022-09-13 银河生物技术有限责任公司 结合死亡受体4和死亡受体5的抗体
NO2768984T3 (ru) 2015-11-12 2018-06-09
KR101926834B1 (ko) * 2017-03-21 2018-12-07 동아에스티 주식회사 항-dr5 항체 및 그의 용도
WO2019092451A1 (en) * 2017-11-13 2019-05-16 Crescendo Biologics Limited Single Domain Antibodies that Bind to CD137
US20190234933A1 (en) * 2018-02-01 2019-08-01 Genadam Therapeutics, Inc. Compositions and assays
CN117285643A (zh) 2022-06-16 2023-12-26 清华大学 一种相变调节套件及其用途
PE20250669A1 (es) 2022-07-15 2025-03-04 Boehringer Ingelheim Int Moleculas de union para el tratamiento del cancer
TW202440614A (zh) 2022-12-23 2024-10-16 比利時商艾伯霖克斯公司 基於蛋白質的接合載體
WO2024153050A1 (zh) * 2023-01-17 2024-07-25 苏州永心生物科技有限公司 Dr5结构域变体及其应用
WO2025006846A2 (en) * 2023-06-29 2025-01-02 Odyssey Therapeutics, Inc. Anti-trailr2 antigen-binding proteins and uses thereof

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IL221289A0 (en) 2012-10-31
BR112012019924A2 (pt) 2017-05-02
US20150259426A1 (en) 2015-09-17
MX2012009328A (es) 2012-11-30
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