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EA201190139A1 - Производные тиенопиримидиндиона в качестве модуляторов trpa1 - Google Patents

Производные тиенопиримидиндиона в качестве модуляторов trpa1

Info

Publication number
EA201190139A1
EA201190139A1 EA201190139A EA201190139A EA201190139A1 EA 201190139 A1 EA201190139 A1 EA 201190139A1 EA 201190139 A EA201190139 A EA 201190139A EA 201190139 A EA201190139 A EA 201190139A EA 201190139 A1 EA201190139 A1 EA 201190139A1
Authority
EA
Eurasian Patent Office
Prior art keywords
trpa1
derivatives
thyenopyrimidindion
subfamily
modulators
Prior art date
Application number
EA201190139A
Other languages
English (en)
Other versions
EA022029B1 (ru
Inventor
Сукеерти Кумар
Абрахам Томас
Найан Татерао Вагхмар
Санджей Маргал
Неелима Кхайраткар-Джоши
Индранил Мухопадхяй
Original Assignee
Гленмарк Фармасьютикалс, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гленмарк Фармасьютикалс, С.А. filed Critical Гленмарк Фармасьютикалс, С.А.
Publication of EA201190139A1 publication Critical patent/EA201190139A1/ru
Publication of EA022029B1 publication Critical patent/EA022029B1/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к новым производным тиенопиримидиндиона в качестве TRPA (транзиторный рецепторный потенциал в подсемействе А) модуляторов. В частности, описанные здесь соединения являются полезными для лечения или профилактики заболеваний, условий и/или расстройств, моделируемых TRPA1 (транзиторный рецепторный потенциал подсемейства А, член 1). Также предусмотрены способы получения описанных здесь соединений, промежуточных соединений, используемых в их синтезе, их фармацевтические композиции и способы лечения или профилактики заболеваний, состояний и/или расстройств, модулируемых TRPA1.
EA201190139A 2009-03-23 2010-03-23 Производные тиенопиримидиндиона в качестве модуляторов trpa1 EA022029B1 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IN665MU2009 2009-03-23
US17135509P 2009-04-21 2009-04-21
IN2213MU2009 2009-09-23
US25199409P 2009-10-15 2009-10-15
IN2906MU2009 2009-12-16
US29447010P 2010-01-12 2010-01-12
PCT/IB2010/000930 WO2010109334A2 (en) 2009-03-23 2010-03-23 Thienopyrimidinedione derivatives as trpa1 modulators

Publications (2)

Publication Number Publication Date
EA201190139A1 true EA201190139A1 (ru) 2012-03-30
EA022029B1 EA022029B1 (ru) 2015-10-30

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EA201190138A EA201190138A1 (ru) 2009-03-23 2010-03-22 Производные фуропиримидиндиона в качестве модуляторов trpa1
EA201190139A EA022029B1 (ru) 2009-03-23 2010-03-23 Производные тиенопиримидиндиона в качестве модуляторов trpa1

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US (4) US20120178766A1 (ru)
EP (3) EP2411395B1 (ru)
JP (2) JP2012521406A (ru)
KR (2) KR20110128898A (ru)
CN (3) CN102361874A (ru)
AP (1) AP2948A (ru)
AU (2) AU2010227225A1 (ru)
BR (2) BRPI1013705A2 (ru)
CA (2) CA2756535A1 (ru)
DK (3) DK2411395T3 (ru)
EA (2) EA201190138A1 (ru)
ES (3) ES2424341T3 (ru)
HU (1) HUE024538T2 (ru)
IL (2) IL215177A (ru)
MX (1) MX2011009822A (ru)
PE (2) PE20120834A1 (ru)
PL (3) PL2411395T3 (ru)
PT (3) PT2411395E (ru)
SG (4) SG184767A1 (ru)
SI (3) SI2411395T1 (ru)
WO (2) WO2010109329A1 (ru)
ZA (2) ZA201107649B (ru)

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WO2013014597A1 (en) 2011-07-25 2013-01-31 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising a trpa1 antagonist and a steroid
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JP6667093B2 (ja) * 2014-08-11 2020-03-18 ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ， ＬＬＣ ピリド［２，３−ｄ］ピリミジン−２，４（１Ｈ，３Ｈ）−ジオン誘導体
JP6667092B2 (ja) * 2014-08-11 2020-03-18 ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ， ＬＬＣ ピロロ［３，２−ｄ］ピリミジン−２，４（３Ｈ，５Ｈ）−ジオン誘導体
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US20190175599A1 (en) * 2014-09-16 2019-06-13 Glemark Pharmaceuticals S.A. Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
US11229628B2 (en) 2015-01-09 2022-01-25 Duke University TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
WO2017060488A1 (en) 2015-10-09 2017-04-13 Almirall, S.A. New trpa1 antagonists
WO2017064068A1 (en) 2015-10-14 2017-04-20 Almirall, S.A. New trpa1 antagonists
JP2019513749A (ja) * 2016-04-07 2019-05-30 デューク ユニバーシティ 衛生化及び麻酔用のｔｒｐｖ４及びｔｒｐａ１の小分子二重阻害剤
CN114874209B (zh) * 2017-03-07 2024-08-06 豪夫迈·罗氏有限公司 噁二唑瞬时受体电位通道抑制剂
CN109422749B (zh) * 2017-08-21 2023-01-24 重庆医药工业研究院有限责任公司 一种抑制单羧酸转运蛋白的嘧啶二酮衍生物
JP7565440B2 (ja) 2020-10-14 2024-10-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｒｐａ１阻害剤としてのテトラゾール誘導体
JP7565439B2 (ja) 2020-10-14 2024-10-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｒｐａ１阻害剤としてのテトラゾール誘導体
WO2022179469A1 (zh) * 2021-02-23 2022-09-01 南京明德新药研发有限公司 噻吩并嘧啶二酮类化合物及其应用
JP7565457B2 (ja) 2021-04-14 2024-10-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ＴＲＰＡ１阻害剤としての３Ｈ，４Ｈ－チエノ－［２，３－ｄ］ピリミジン－４－オン誘導体
CN114671875A (zh) * 2022-04-27 2022-06-28 成都施贝康生物医药科技有限公司 新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途
CN114656480B (zh) * 2022-04-27 2024-01-26 成都施贝康生物医药科技有限公司 噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途

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