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EA201170098A1 - Замещенные производные алкилпиримидин-4-она - Google Patents

Замещенные производные алкилпиримидин-4-она

Info

Publication number
EA201170098A1
EA201170098A1 EA201170098A EA201170098A EA201170098A1 EA 201170098 A1 EA201170098 A1 EA 201170098A1 EA 201170098 A EA201170098 A EA 201170098A EA 201170098 A EA201170098 A EA 201170098A EA 201170098 A1 EA201170098 A1 EA 201170098A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
alkylpyrimidin
substituted
atom
halogen atom
Prior art date
Application number
EA201170098A
Other languages
English (en)
Inventor
Од Фэйоль
Алистер Локхед
Мурад Саади
Жюльен Ваше
Филипп Иэш
Original Assignee
Мицубиси Танабе Фарма Корпорейшн
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мицубиси Танабе Фарма Корпорейшн, Санофи-Авентис filed Critical Мицубиси Танабе Фарма Корпорейшн
Publication of EA201170098A1 publication Critical patent/EA201170098A1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

Производное пиримидона, представленное формулой (I), или его соль, или его сольват, или его гидрат, в которой Х обозначает метилен, NH, атом азота, замещенный группой С(О)-O-(C-алкил); R1 обозначает кольцо 2-, 3- или 4-пиридина или кольцо 2-, 4- или 5-пиримидина, в случае необходимости замещенное Cалкилом, Cалкоксигруппой или атомом галогена; R2 обозначает атом водорода, Cалкил или атом галогена; R3 обозначает Cалкил, в случае необходимости замещенный, R4 обозначает атом водорода, атом галогена, гидроксильную группу, Cалкил; m означает от 1 до 2, когда Х обозначает метилен, или m означает 2, когда Х обозначает NH, атом азота, замещенный группой C(O)-O-(Cалкил); в форме свободного основания или соли присоединения с кислотой. Применение в терапии.
EA201170098A 2008-06-26 2009-06-25 Замещенные производные алкилпиримидин-4-она EA201170098A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290615A EP2138494A1 (en) 2008-06-26 2008-06-26 Substituted alkyl pyrimidin-4-one derivatives
PCT/IB2009/006568 WO2009156864A2 (en) 2008-06-26 2009-06-25 Substituted alkyl pyrimidin-4-one derivatives

Publications (1)

Publication Number Publication Date
EA201170098A1 true EA201170098A1 (ru) 2011-08-30

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Country Status (16)

Country Link
US (1) US9073914B2 (ru)
EP (2) EP2138494A1 (ru)
JP (1) JP5501355B2 (ru)
KR (1) KR20110027804A (ru)
CN (1) CN102137861A (ru)
AR (1) AR072225A1 (ru)
AU (1) AU2009263850A1 (ru)
BR (1) BRPI0914759A2 (ru)
CA (1) CA2728695A1 (ru)
EA (1) EA201170098A1 (ru)
IL (1) IL210173A0 (ru)
MX (1) MX2010014065A (ru)
NZ (1) NZ590080A (ru)
TW (1) TW201004953A (ru)
WO (1) WO2009156864A2 (ru)
ZA (1) ZA201009272B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2138493A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives
EP2138492A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
EP2138495A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138485A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted N-Oxide pyrazine derivatives
EP2138498A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted tricyclic derivatives against neurodegenerative diseases
EP2138488A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP7071917B2 (ja) 2015-12-09 2022-05-19 カデント セラピューティクス，インコーポレーテッド ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用
JP7332472B2 (ja) * 2016-12-22 2023-08-23 ノバルティス アーゲー Ｎｍｄａ受容体モジュレーターおよびその使用
MA53351B1 (fr) 2018-08-03 2023-08-31 Novartis Ag Modulateurs des récepteurs nmda hétéroaromatiques et leurs utilisations

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5170780A (ja) 1974-12-17 1976-06-18 Nippon Shinyaku Co Ltd Shinkinabenzoguanidoruino seiho
EG13192A (en) 1976-02-10 1982-12-31 Rhone Poulenc Ind Nouveaux derives du dithiole-1,2 leur preparation et les compositions qui les contiennent
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity
US4304663A (en) * 1981-01-19 1981-12-08 Manders Logan J Oil filter apparatus
US4406897A (en) * 1981-07-06 1983-09-27 William H. Rorer, Inc. 6-Aryl-4-hydrazinyl-s-triazin-2-ones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
WO1997016430A1 (en) 1995-11-01 1997-05-09 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
IL123986A (en) 1997-04-24 2011-10-31 Organon Nv Medicinal compounds
EP1136484A1 (en) 2000-03-23 2001-09-26 Sanofi-Synthelabo 2-(Arylalkylamino)pyrimidone derivatives
CA2665516A1 (en) 2001-04-26 2002-11-07 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
MXPA04002632A (es) * 2001-09-21 2004-07-08 Mitsubishin Pharma Corp Derivados de 2-pirimidinil-6,7,8,9-tetrahidropirimido-[1,2-a] pirimidin-4-ona y 7-pirimidinil-2,3. dihidroimidazo [1,2-a] pirimidim-5 (1h)-ona substituidos para desordenes neurodegenerativos.
EP1340759A1 (en) * 2002-02-28 2003-09-03 Sanofi-Synthelabo 1-[alkyl], 1-[(heteroaryl)alkyl] and 1-[(aryl)alkyl]-7-(pyrimidin-4-yl)-imidazo[1,2-a]pyrimidin-5(1H)-one derivatives
CA2495661C (en) 2002-08-16 2011-06-14 Kinacia Pty Ltd. Inhibition of phosphoinositide 3-kinase beta
EP1454909B1 (en) 2003-03-07 2008-08-20 Sanofi Aventis 8'-pyridinyl-dihydrospiro (cycloalkyl) -pyrimido (1,2-a) pyrimidin-6-one and 8'-pyrimidinyl-dihydrospiro (cycloalkyl) pyrimido (1,2-a) pyrimidin-6 derivatives -one and their use against neurodegenerative diseases
EP1460076A1 (en) * 2003-03-21 2004-09-22 Sanofi-Synthelabo Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives
US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
EP1790649A1 (en) * 2005-11-21 2007-05-30 Sanofi-Aventis Substituted bicyclic pyrimidone derivatives
EP1939187A1 (en) * 2006-12-20 2008-07-02 Sanofi-Aventis Substituted heteroaryl pyridopyrimidone derivatives
EP2090579A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted heteroarylamide diazepinopyrimidone derivatives
EP2090578A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta
EP2138493A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives
EP2138488A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP2138495A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138492A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
EP2138485A1 (en) 2008-06-26 2009-12-30 sanofi-aventis Substituted N-Oxide pyrazine derivatives
EP2320905B1 (en) * 2008-08-11 2017-06-28 Glaxosmithkline LLC Novel adenine derivatives

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CA2728695A1 (en) 2009-12-30
EP2321315B1 (en) 2015-06-03
CN102137861A (zh) 2011-07-27
US20110144092A1 (en) 2011-06-16
US9073914B2 (en) 2015-07-07
KR20110027804A (ko) 2011-03-16
JP2011525908A (ja) 2011-09-29
ZA201009272B (en) 2012-03-28
IL210173A0 (en) 2011-03-31
EP2321315A2 (en) 2011-05-18
EP2138494A1 (en) 2009-12-30
NZ590080A (en) 2011-11-25
BRPI0914759A2 (pt) 2015-10-20
AR072225A1 (es) 2010-08-11
WO2009156864A2 (en) 2009-12-30
MX2010014065A (es) 2011-05-25
WO2009156864A3 (en) 2010-04-01
AU2009263850A1 (en) 2009-12-30
JP5501355B2 (ja) 2014-05-21
TW201004953A (en) 2010-02-01

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