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EA201101180A1 - Производные триазоло[4,3-в]пиридазина и их применение для рака предстательной железы - Google Patents

Производные триазоло[4,3-в]пиридазина и их применение для рака предстательной железы

Info

Publication number
EA201101180A1
EA201101180A1 EA201101180A EA201101180A EA201101180A1 EA 201101180 A1 EA201101180 A1 EA 201101180A1 EA 201101180 A EA201101180 A EA 201101180A EA 201101180 A EA201101180 A EA 201101180A EA 201101180 A1 EA201101180 A1 EA 201101180A1
Authority
EA
Eurasian Patent Office
Prior art keywords
prostate cancer
pyridazin
triazolo
derivatives
application
Prior art date
Application number
EA201101180A
Other languages
English (en)
Other versions
EA019647B1 (ru
Inventor
Роберт Хью Брэдбери
Грегори Ричард Карр
Алфред Артур Рейбоу
Сриниваза Рао-Коруподжу
Харикришна Тумма
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201101180A1 publication Critical patent/EA201101180A1/ru
Publication of EA019647B1 publication Critical patent/EA019647B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение охватывает бициклические соединения формулы (I)где, R, R, L, L, J, Y, k, n, p и r имеют значения, указанные в описании. Настоящее изобретение также относится к способам получения таких соединений, фармацевтическим композициям, которые их содержат, и к их применению для лечения состояний, связанных с андрогеновым рецептором, в особенности рака предстательной железы.
EA201101180A 2009-02-10 2010-02-08 ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-b]ПИРИДАЗИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ EA019647B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15122109P 2009-02-10 2009-02-10
US18776609P 2009-06-17 2009-06-17
PCT/GB2010/050191 WO2010092371A1 (en) 2009-02-10 2010-02-08 Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer

Publications (2)

Publication Number Publication Date
EA201101180A1 true EA201101180A1 (ru) 2012-03-30
EA019647B1 EA019647B1 (ru) 2014-05-30

Family

ID=42115693

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201101180A EA019647B1 (ru) 2009-02-10 2010-02-08 ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-b]ПИРИДАЗИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ

Country Status (26)

Country Link
US (2) US8258140B2 (ru)
EP (1) EP2396333B1 (ru)
JP (1) JP5059977B2 (ru)
KR (1) KR20110113755A (ru)
CN (1) CN102388048B (ru)
AR (1) AR075383A1 (ru)
AU (1) AU2010212590B2 (ru)
CA (1) CA2749926A1 (ru)
CL (1) CL2011001920A1 (ru)
CO (1) CO6410299A2 (ru)
CR (1) CR20110427A (ru)
CU (1) CU20110158A7 (ru)
DO (1) DOP2011000258A (ru)
EA (1) EA019647B1 (ru)
EC (1) ECSP11011257A (ru)
ES (1) ES2427917T3 (ru)
IL (1) IL214112A0 (ru)
MX (1) MX2011008452A (ru)
NI (1) NI201100156A (ru)
PE (1) PE20120603A1 (ru)
SG (1) SG172986A1 (ru)
SV (1) SV2011003993A (ru)
TW (1) TW201033215A (ru)
UY (1) UY32426A (ru)
WO (1) WO2010092371A1 (ru)
ZA (1) ZA201106625B (ru)

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US20220218701A1 (en) * 2019-05-31 2022-07-14 United States Government As Represented By The Department Of Veterans Affairs Compositions and methods comprising endothelin a receptor antagonists and androgen therapies
US12152035B2 (en) 2020-12-30 2024-11-26 Industrial Technology Research Institute Androgen receptor binding molecule and use thereof
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Also Published As

Publication number Publication date
IL214112A0 (en) 2011-08-31
CA2749926A1 (en) 2010-08-19
UY32426A (es) 2010-09-30
EA019647B1 (ru) 2014-05-30
CU20110158A7 (es) 2012-02-15
NI201100156A (es) 2012-03-19
ECSP11011257A (es) 2011-09-30
KR20110113755A (ko) 2011-10-18
US8258140B2 (en) 2012-09-04
AU2010212590B2 (en) 2013-01-10
US20100267699A1 (en) 2010-10-21
PE20120603A1 (es) 2012-06-14
TW201033215A (en) 2010-09-16
JP5059977B2 (ja) 2012-10-31
ZA201106625B (en) 2013-02-27
CO6410299A2 (es) 2012-03-30
MX2011008452A (es) 2011-12-16
JP2012517462A (ja) 2012-08-02
CL2011001920A1 (es) 2011-10-21
CR20110427A (es) 2011-09-21
CN102388048B (zh) 2014-07-30
SV2011003993A (es) 2012-01-06
CN102388048A (zh) 2012-03-21
EP2396333B1 (en) 2013-07-03
AR075383A1 (es) 2011-03-30
EP2396333A1 (en) 2011-12-21
US20130203714A1 (en) 2013-08-08
WO2010092371A1 (en) 2010-08-19
ES2427917T3 (es) 2013-11-04
SG172986A1 (en) 2011-08-29
HK1164870A1 (en) 2012-09-28
AU2010212590A1 (en) 2011-08-04
DOP2011000258A (es) 2011-09-30

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