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EA201101041A1 - Производные пиридазинона - Google Patents

Производные пиридазинона

Info

Publication number
EA201101041A1
EA201101041A1 EA201101041A EA201101041A EA201101041A1 EA 201101041 A1 EA201101041 A1 EA 201101041A1 EA 201101041 A EA201101041 A EA 201101041A EA 201101041 A EA201101041 A EA 201101041A EA 201101041 A1 EA201101041 A1 EA 201101041A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyridazinon
derivatives
compounds
formula
tyrosine kinase
Prior art date
Application number
EA201101041A
Other languages
English (en)
Other versions
EA019322B1 (ru
Inventor
Дитер Дорш
Оливер Шадт
Франк Штибер
Андрее Блаукат
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201101041A1 publication Critical patent/EA201101041A1/ru
Publication of EA019322B1 publication Critical patent/EA019322B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединения формулы (I)где D, R, R, R, Rимеют значения, указанные в п.1, являются ингибиторами тирозинкиназ, в особенности Met киназы, и могут применяться, в частности, для лечения опухолей.
EA201101041A 2009-01-07 2009-12-10 Производные пиридазинона EA019322B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009003954A DE102009003954A1 (de) 2009-01-07 2009-01-07 Pyridazinonderivate
PCT/EP2009/008840 WO2010078910A1 (de) 2009-01-07 2009-12-10 Pyridazinonderivate

Publications (2)

Publication Number Publication Date
EA201101041A1 true EA201101041A1 (ru) 2012-01-30
EA019322B1 EA019322B1 (ru) 2014-02-28

Family

ID=41719075

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201101041A EA019322B1 (ru) 2009-01-07 2009-12-10 Производные пиридазинона

Country Status (24)

Country Link
US (2) US8853211B2 (ru)
EP (1) EP2373644B1 (ru)
JP (1) JP2012514613A (ru)
KR (1) KR101674695B1 (ru)
CN (1) CN102272125B (ru)
AR (1) AR075122A1 (ru)
AU (1) AU2009336852B2 (ru)
BR (1) BRPI0923913B1 (ru)
CA (1) CA2748911C (ru)
CY (1) CY1113698T1 (ru)
DE (1) DE102009003954A1 (ru)
DK (1) DK2373644T3 (ru)
EA (1) EA019322B1 (ru)
ES (1) ES2396301T3 (ru)
HR (1) HRP20120979T1 (ru)
IL (1) IL213828A (ru)
MX (1) MX2011007165A (ru)
PL (1) PL2373644T3 (ru)
PT (1) PT2373644E (ru)
SG (1) SG172421A1 (ru)
SI (1) SI2373644T1 (ru)
SM (1) SMT201300004B (ru)
WO (1) WO2010078910A1 (ru)
ZA (1) ZA201105780B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009003954A1 (de) * 2009-01-07 2010-07-08 Merck Patent Gmbh Pyridazinonderivate
DE102009004061A1 (de) * 2009-01-08 2010-07-15 Merck Patent Gmbh Pyridazinonderivate
CN102731409A (zh) * 2011-04-08 2012-10-17 中国科学院上海药物研究所 一类哒嗪酮类化合物，其药物组合物、制备方法及用途
US10750742B2 (en) 2015-12-22 2020-08-25 Syngenta Participations Ag Pesticidally active pyrazole derivatives
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
KR102476708B1 (ko) * 2017-11-01 2022-12-09 삼성전자주식회사 광학 필터, 및 이를 포함하는 카메라 모듈 및 전자 장치
KR102673362B1 (ko) * 2018-03-27 2024-06-05 삼성전자주식회사 근적외선 흡수 필름, 광학 필터 및 전자 장치
CN108752322A (zh) * 2018-09-12 2018-11-06 广州新民培林医药科技有限公司 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用
CN115583939A (zh) * 2022-11-04 2023-01-10 苏州莱安医药化学技术有限公司 一种特泊替尼中间体的合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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JPS5795964A (en) 1980-12-04 1982-06-15 Morishita Seiyaku Kk Preparation of 2-substituted-3(2h)-pyridazinone derivative
US4397854A (en) 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
AU691673B2 (en) 1994-11-14 1998-05-21 Dow Agrosciences Llc Pyridazinones and their use as fungicides
US5635494A (en) 1995-04-21 1997-06-03 Rohm And Haas Company Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
HUP9901155A3 (en) 1996-02-13 2003-04-28 Astrazeneca Ab Quinazoline derivatives as vegf inhibitors
ATE211134T1 (de) 1996-03-05 2002-01-15 4-anilinochinazolin derivate
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
ID24166A (id) 1997-11-19 2000-07-13 Kowa Co Turunan piridazin baru dan obat-obatan yang mengandung hal yang sama sebagai ramuan efektif
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
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CN1431999A (zh) 2000-05-31 2003-07-23 阿斯特拉曾尼卡有限公司 具有血管损伤活性的吲哚衍生物
KR20030014425A (ko) 2000-07-07 2003-02-17 앤지오젠 파마슈티칼스 리미티드 혈관 손상제인 콜치놀 유도체
SK52003A3 (en) 2000-07-07 2003-07-01 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors, method for their preparation and pharmaceutical composition comprising the same
CZ2004516A3 (cs) 2001-10-31 2004-08-18 Merckápatentágmbh Inhibitor fosfodiesterázy typu @Ź jeho kombinace s jinými drogami a jeho použití
DE102005057924A1 (de) 2005-12-05 2007-06-06 Merck Patent Gmbh Pyridazinonderivate
US7825137B2 (en) 2005-12-05 2010-11-02 Pfizer Inc. Method of treating abnormal cell growth
DE102006037478A1 (de) 2006-08-10 2008-02-14 Merck Patent Gmbh 2-(Heterocyclylbenzyl)-pyridazinonderivate
US8340070B2 (en) * 2006-10-03 2012-12-25 Qualcomm Incorporated Resource partitioning for wireless communication systems
DE102007025717A1 (de) * 2007-06-01 2008-12-11 Merck Patent Gmbh Arylether-pyridazinonderivate
DE102007025718A1 (de) * 2007-06-01 2008-12-04 Merck Patent Gmbh Pyridazinonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008062826A1 (de) * 2008-12-23 2010-07-01 Merck Patent Gmbh Pyridazinonderivate
DE102009003954A1 (de) * 2009-01-07 2010-07-08 Merck Patent Gmbh Pyridazinonderivate

Also Published As

Publication number Publication date
AU2009336852B2 (en) 2015-10-29
AR075122A1 (es) 2011-03-09
BRPI0923913B1 (pt) 2021-05-25
CN102272125A (zh) 2011-12-07
SI2373644T1 (sl) 2013-02-28
EP2373644A1 (de) 2011-10-12
US20110269765A1 (en) 2011-11-03
ZA201105780B (en) 2012-04-25
HK1164853A1 (en) 2012-09-28
SG172421A1 (en) 2011-07-28
IL213828A (en) 2014-03-31
DK2373644T3 (da) 2012-12-10
JP2012514613A (ja) 2012-06-28
PL2373644T3 (pl) 2013-03-29
KR101674695B1 (ko) 2016-11-09
US9376426B2 (en) 2016-06-28
US8853211B2 (en) 2014-10-07
DE102009003954A1 (de) 2010-07-08
CN102272125B (zh) 2014-01-08
SMT201300004B (it) 2013-03-08
KR20110105848A (ko) 2011-09-27
US20140148463A1 (en) 2014-05-29
CA2748911A1 (en) 2010-07-15
CY1113698T1 (el) 2016-06-22
ES2396301T3 (es) 2013-02-20
PT2373644E (pt) 2013-01-14
CA2748911C (en) 2017-05-16
BRPI0923913A2 (pt) 2020-08-11
EA019322B1 (ru) 2014-02-28
EP2373644B1 (de) 2012-10-24
AU2009336852A1 (en) 2011-08-18
IL213828A0 (en) 2011-07-31
MX2011007165A (es) 2011-08-04
WO2010078910A1 (de) 2010-07-15
HRP20120979T1 (hr) 2012-12-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU