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EA201100689A1 - N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы - Google Patents

N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы

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Publication number
EA201100689A1
EA201100689A1 EA201100689A EA201100689A EA201100689A1 EA 201100689 A1 EA201100689 A1 EA 201100689A1 EA 201100689 A EA201100689 A EA 201100689A EA 201100689 A EA201100689 A EA 201100689A EA 201100689 A1 EA201100689 A1 EA 201100689A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
sulphonylpirroles
histondezetylases
application
compounds
Prior art date
Application number
EA201100689A
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English (en)
Inventor
Томас Майер
Томас Бэр
Томас Беккерс
Астрид Циммерманн
Зигфрид Шнайдер
Фолькер Гекелер
Original Assignee
4Сц Аг
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Filing date
Publication date
Application filed by 4Сц Аг filed Critical 4Сц Аг
Publication of EA201100689A1 publication Critical patent/EA201100689A1/ru

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

В заявке описаны соединения некоторой формулы I, в которой R1, R2, R3, R4, R5, R6 и R7, обладающие значениями, указанными в описании, являются новыми эффективными ингибиторами HDAC.
EA201100689A 2005-03-15 2006-03-14 N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы EA201100689A1 (ru)

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Application Number Priority Date Filing Date Title
EP05102019 2005-03-15
EP05108735 2005-09-21

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EA201100689A1 true EA201100689A1 (ru) 2011-10-31

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EA201100689A EA201100689A1 (ru) 2005-03-15 2006-03-14 N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы

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US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
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