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EA201071218A1 - Улучшенные композиции для активных фармацевтических компонентов с плохой проницаемостью - Google Patents

Улучшенные композиции для активных фармацевтических компонентов с плохой проницаемостью

Info

Publication number
EA201071218A1
EA201071218A1 EA201071218A EA201071218A EA201071218A1 EA 201071218 A1 EA201071218 A1 EA 201071218A1 EA 201071218 A EA201071218 A EA 201071218A EA 201071218 A EA201071218 A EA 201071218A EA 201071218 A1 EA201071218 A1 EA 201071218A1
Authority
EA
Eurasian Patent Office
Prior art keywords
active pharmaceutical
improved compositions
permeability
pharmaceutical components
bad permeability
Prior art date
Application number
EA201071218A
Other languages
English (en)
Other versions
EA032766B1 (ru
Inventor
Ян П. Мешвитцер
Алдо Кет
Хайке Динтерхайдорн
Original Assignee
Эбботт Продактс Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эбботт Продактс Гмбх filed Critical Эбботт Продактс Гмбх
Publication of EA201071218A1 publication Critical patent/EA201071218A1/ru
Publication of EA032766B1 publication Critical patent/EA032766B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к пероральной фармацевтической лекарственной форме, которая содержит активный фармацевтический компонент с плохой проницаемостью и по меньшей мере одно вещество, улучшающее проницаемость, где вещество, улучшающее проницаемость, термостабильно встроено в водорастворимую матрицу из водорастворимого носителя, и к термостабильным составам, которые можно использовать для улучшения биодоступности.
EA201071218A 2008-04-22 2009-04-21 Улучшенные композиции для активных фармацевтических компонентов с плохой проницаемостью EA032766B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08103657 2008-04-22
PCT/EP2009/054720 WO2009130204A2 (en) 2008-04-22 2009-04-21 Improved formulations for poorly permeable active pharmaceutical ingredients

Publications (2)

Publication Number Publication Date
EA201071218A1 true EA201071218A1 (ru) 2011-06-30
EA032766B1 EA032766B1 (ru) 2019-07-31

Family

ID=39816874

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071218A EA032766B1 (ru) 2008-04-22 2009-04-21 Улучшенные композиции для активных фармацевтических компонентов с плохой проницаемостью

Country Status (18)

Country Link
US (1) US20090263479A1 (ru)
EP (1) EP2268270A2 (ru)
JP (1) JP5726067B2 (ru)
KR (1) KR20110005883A (ru)
CN (1) CN102119025B (ru)
AR (1) AR071375A1 (ru)
AU (1) AU2009240050A1 (ru)
BR (1) BRPI0910758A2 (ru)
CA (1) CA2720658C (ru)
CO (1) CO6300932A2 (ru)
DO (1) DOP2010000318A (ru)
EA (1) EA032766B1 (ru)
EC (1) ECSP10010514A (ru)
IL (1) IL208370A0 (ru)
MX (1) MX2010011564A (ru)
NZ (1) NZ588369A (ru)
TW (1) TW200948399A (ru)
WO (1) WO2009130204A2 (ru)

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US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
AR071375A1 (es) 2008-04-22 2010-06-16 Solvay Pharm Gmbh Formulaciones para ingredientes farmaceuticos activos de permeabilidad deficiente, proceso de preparacion y producto
WO2014048783A1 (en) 2012-09-27 2014-04-03 Basf Se A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin e-derivative and at least one hydrophilic polymer
US9744240B2 (en) 2012-09-27 2017-08-29 Basf Se Storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin E-derivative and at least one hydrophilic polymer
US9789063B2 (en) 2012-09-27 2017-10-17 Basf Se Storage-stable dust-free homogeneous particulate formulation
WO2014048782A1 (en) 2012-09-27 2014-04-03 Basf Se A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin e-derivative and at least one hydrophilic polymer
DK2953617T3 (da) * 2013-02-06 2020-01-20 Hermes Arzneimittel Gmbh Farmaceutiske sammensætninger, der inkorporerer lavdosislægemidler
RU2720680C2 (ru) 2014-06-18 2020-05-12 Ф. Хоффманн-Ля Рош Аг Новая фармацевтическая композиция, содержащая неионные сурфактанты
ES2829644T3 (es) 2014-06-20 2021-06-01 Hermes Arzneimittel Gmbh Composición farmacéutica oral de sabor enmascarado
CN111053755B (zh) * 2019-12-31 2022-03-29 金日制药（中国）有限公司 一种高渗透性的头孢克肟胶囊制剂制备方法
CN115209910A (zh) * 2020-03-18 2022-10-18 四川海思科制药有限公司 口服药物组合物
CN112704649A (zh) * 2020-12-30 2021-04-27 广东臻香荟生物科技有限公司 一种具备抑菌性能的香薰液
JP7368548B2 (ja) * 2021-07-02 2023-10-24 昊運股▲フン▼有限公司 薬学的組成物及びその使用
CN114601800B (zh) * 2021-09-28 2023-07-28 天津瑞普生物技术股份有限公司 一种甲磷丙泊酚钠无菌粉针剂及其制备方法
CN119677540A (zh) * 2022-03-04 2025-03-21 阿比泰克公司 用于基于脂质的药物递送系统的片剂剂型
WO2023174433A1 (en) * 2022-03-18 2023-09-21 Smart Pharmaceutical (Suzhou) Co., Ltd. Solid, semisolid, or liquid compositions for augmenting the stability, permeability and bioavailability of active pharmaceutical substances

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FR2790388B1 (fr) * 1999-03-04 2001-04-13 Synthelabo Compositions pharmaceutiques comprenant un benzamide et au moins un promoteur d'absorption
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Also Published As

Publication number Publication date
CN102119025A (zh) 2011-07-06
WO2009130204A3 (en) 2010-08-05
EA032766B1 (ru) 2019-07-31
AR071375A1 (es) 2010-06-16
CA2720658C (en) 2016-07-12
CN102119025B (zh) 2014-09-03
CA2720658A1 (en) 2009-10-29
US20090263479A1 (en) 2009-10-22
JP5726067B2 (ja) 2015-05-27
BRPI0910758A2 (pt) 2018-03-20
JP2011518208A (ja) 2011-06-23
AU2009240050A1 (en) 2009-10-29
WO2009130204A2 (en) 2009-10-29
EP2268270A2 (en) 2011-01-05
MX2010011564A (es) 2011-03-02
ECSP10010514A (es) 2010-11-30
TW200948399A (en) 2009-12-01
DOP2010000318A (es) 2011-01-15
NZ588369A (en) 2012-06-29
CO6300932A2 (es) 2011-07-21
IL208370A0 (en) 2010-12-30
KR20110005883A (ko) 2011-01-19

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM