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EA201071202A1 - Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-7 - Google Patents

Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-7

Info

Publication number
EA201071202A1
EA201071202A1 EA201071202A EA201071202A EA201071202A1 EA 201071202 A1 EA201071202 A1 EA 201071202A1 EA 201071202 A EA201071202 A EA 201071202A EA 201071202 A EA201071202 A EA 201071202A EA 201071202 A1 EA201071202 A1 EA 201071202A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indols
models
nicotine receptor
acetylcholine alpha
receptor acetylcholine
Prior art date
Application number
EA201071202A
Other languages
English (en)
Other versions
EA017726B1 (ru
Inventor
Кевин Диннелл
Эндрю П. Лайтфут
Говард Роберт Маршалл
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0807050A external-priority patent/GB0807050D0/en
Priority claimed from GB0810229A external-priority patent/GB0810229D0/en
Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Publication of EA201071202A1 publication Critical patent/EA201071202A1/ru
Publication of EA017726B1 publication Critical patent/EA017726B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение относится к модуляции никотинового α7-рецептора ацетилхолина (nAChR) с помощью соединения из перечня А или его соли, которое может представлять собой N-[(2-трифторметил-1H-индол-5-ил)метил]-5-(трифторметил)-2-пиримидинкарбоксамид.
EA201071202A 2008-04-17 2009-04-16 Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-7 EA017726B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0807050A GB0807050D0 (en) 2008-04-17 2008-04-17 Novel compounds
GB0810229A GB0810229D0 (en) 2008-06-04 2008-06-04 Novel compounds
PCT/EP2009/054495 WO2009127679A1 (en) 2008-04-17 2009-04-16 Indoles as modulators of nicoticic acetylcholine receptor subtype alpha-7

Publications (2)

Publication Number Publication Date
EA201071202A1 true EA201071202A1 (ru) 2011-06-30
EA017726B1 EA017726B1 (ru) 2013-02-28

Family

ID=40791353

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201071201A EA018113B1 (ru) 2008-04-17 2009-04-16 Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-71
EA201071202A EA017726B1 (ru) 2008-04-17 2009-04-16 Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-7

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201071201A EA018113B1 (ru) 2008-04-17 2009-04-16 Индолы в качестве модуляторов никотинового рецептора ацетилхолина подтипа альфа-71

Country Status (19)

Country Link
US (2) US8283365B2 (ru)
EP (2) EP2279184B1 (ru)
JP (2) JP2011516599A (ru)
KR (2) KR20100133016A (ru)
CN (2) CN102066357B (ru)
AR (1) AR071203A1 (ru)
AU (2) AU2009237650B2 (ru)
BR (2) BRPI0911682A2 (ru)
CA (2) CA2721630A1 (ru)
CL (1) CL2009000916A1 (ru)
EA (2) EA018113B1 (ru)
ES (2) ES2392795T3 (ru)
IL (2) IL208574A (ru)
MX (2) MX2010011359A (ru)
PE (1) PE20091724A1 (ru)
TW (1) TW201004939A (ru)
UY (1) UY31769A1 (ru)
WO (2) WO2009127679A1 (ru)
ZA (2) ZA201006856B (ru)

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JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
CA2697974C (en) 2007-10-18 2015-06-30 Janssen Pharmaceutica Nv Trisubstituted 1,2,4-triazoles
WO2009097306A1 (en) * 2008-01-30 2009-08-06 Cephalon, Inc. Substituted pyridazine derivatives which have histamine h3 antagonist activity
CN102066343B (zh) 2008-03-19 2013-12-04 詹森药业有限公司 作为烟碱乙酰胆碱受体调节剂的三取代1，2，4-三唑类
WO2009135944A1 (en) 2008-05-09 2009-11-12 Janssen Pharmaceutica Nv Trisubstituted pyrazoles as acetylcholine receptor modulators
NZ596390A (en) 2009-04-16 2013-08-30 Proximagen Ltd Indole derivative modulators of the alpha 7 nachr
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
GB201012686D0 (en) * 2010-07-28 2010-09-15 Glaxo Group Ltd Novel compounds
JO3078B1 (ar) 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
US20130310419A1 (en) 2011-02-03 2013-11-21 Lupin Limited Pyrrole derivatives used as modulators of alpha7 nachr
CA2826792A1 (en) 2011-02-23 2012-08-30 Lupin Limited Heteroaryl derivatives as alpha7 nachr modulators
CN103561740A (zh) * 2011-03-18 2014-02-05 诺瓦提斯公司 用于帕金森病中多巴胺诱导的运动障碍的α7烟碱性乙酰胆碱受体活化剂和mGluR5拮抗剂的组合
CA2829860A1 (en) 2011-03-31 2012-10-04 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
EP2729455B1 (en) 2011-07-05 2016-09-14 Lupin Limited Biaryl derivatives as nachr modulators
NZ629453A (en) 2012-03-06 2016-04-29 Lupin Ltd Thiazole derivatives as alpha 7 nachr modulators
CA2871651A1 (en) * 2012-05-08 2013-11-14 Anvyl Llc Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
KR20150064098A (ko) * 2012-10-02 2015-06-10 다이닛본 스미토모 세이야꾸 가부시끼가이샤 이미다졸 유도체
EP2945936A1 (en) 2012-11-12 2015-11-25 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
CN103006642B (zh) * 2013-01-04 2014-10-22 中国药科大学 一类炔亚甲基吲哚-2-酮类衍生物的用途
US9617211B2 (en) 2013-01-16 2017-04-11 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
US10058310B2 (en) 2013-03-13 2018-08-28 Ethicon Llc Electrosurgical device with drum-driven articulation
CA2892682A1 (en) 2013-03-13 2014-09-18 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
AU2014282886A1 (en) 2013-06-17 2015-12-17 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
EP3122187A4 (en) * 2014-03-25 2017-11-15 Emicipi LLC Treatment of rett syndrome
JP6870304B2 (ja) * 2016-12-05 2021-05-12 住友電気工業株式会社 半導体装置の製造方法
EP3558992A4 (en) * 2016-12-15 2020-12-02 ONO Pharmaceutical Co., Ltd. TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK)
HU231333B1 (hu) * 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok
IL293340A (en) 2019-12-02 2022-07-01 Storm Therapeutics Ltd Polyheterocyclic compounds as mettl3 inhibitors
CN111285792B (zh) * 2020-03-23 2023-05-02 三峡大学 2-取代吲哚化合物及其制备方法

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SE9903997D0 (sv) 1999-11-03 1999-11-03 Astra Ab New compounds
GB0403155D0 (en) * 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
RU2010137114A (ru) * 2008-02-07 2012-03-20 Эбботт Лэборетриз (Us) Амидные производные как позитивные аллостерические модуляторы и способы их применения

Also Published As

Publication number Publication date
IL208574A (en) 2014-04-30
EP2279184A1 (en) 2011-02-02
CN102066357B (zh) 2014-04-09
WO2009127678A1 (en) 2009-10-22
CN102066356A (zh) 2011-05-18
US8283365B2 (en) 2012-10-09
IL208575A (en) 2014-04-30
EP2279184B1 (en) 2012-08-08
CA2725441A1 (en) 2009-10-22
AU2009237650B2 (en) 2012-05-31
KR20100133016A (ko) 2010-12-20
IL208574A0 (en) 2010-12-30
WO2009127679A1 (en) 2009-10-22
EP2279183B1 (en) 2012-08-08
ZA201006856B (en) 2011-06-29
ES2392795T3 (es) 2012-12-13
BRPI0911682A2 (pt) 2015-10-13
CL2009000916A1 (es) 2010-12-31
ES2392796T3 (es) 2012-12-13
US20110034515A1 (en) 2011-02-10
JP2011516599A (ja) 2011-05-26
EA018113B1 (ru) 2013-05-30
EP2279183A1 (en) 2011-02-02
BRPI0910585A2 (pt) 2015-09-22
AU2009237649B2 (en) 2012-07-26
TW201004939A (en) 2010-02-01
CA2721630A1 (en) 2009-10-22
AR071203A1 (es) 2010-06-02
KR20100135911A (ko) 2010-12-27
CA2725441C (en) 2014-05-27
CN102066356B (zh) 2014-06-11
IL208575A0 (en) 2010-12-30
JP2011516598A (ja) 2011-05-26
AU2009237649A1 (en) 2009-10-22
US8377941B2 (en) 2013-02-19
AU2009237650A1 (en) 2009-10-22
US20110028486A1 (en) 2011-02-03
UY31769A1 (es) 2009-09-30
CN102066357A (zh) 2011-05-18
EA201071201A1 (ru) 2011-04-29
MX2010011359A (es) 2010-11-12
MX2010011358A (es) 2010-11-10
ZA201006855B (en) 2011-06-29
EA017726B1 (ru) 2013-02-28
PE20091724A1 (es) 2009-12-06

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU