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EA201070681A1 - Пептиды fviii и их применение для индукции толерантности у больных гемофилией - Google Patents

Пептиды fviii и их применение для индукции толерантности у больных гемофилией

Info

Publication number
EA201070681A1
EA201070681A1 EA201070681A EA201070681A EA201070681A1 EA 201070681 A1 EA201070681 A1 EA 201070681A1 EA 201070681 A EA201070681 A EA 201070681A EA 201070681 A EA201070681 A EA 201070681A EA 201070681 A1 EA201070681 A1 EA 201070681A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hemophilia
tolerance
patients
induction
application
Prior art date
Application number
EA201070681A
Other languages
English (en)
Other versions
EA019370B1 (ru
Inventor
Дэвид Рэйт
Original Assignee
Эпитоп Текнолоджи (Бристоль) Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эпитоп Текнолоджи (Бристоль) Лимитед filed Critical Эпитоп Текнолоджи (Бристоль) Лимитед
Publication of EA201070681A1 publication Critical patent/EA201070681A1/ru
Publication of EA019370B1 publication Critical patent/EA019370B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к пептиду, содержащему последовательность серединных остатков, производную FVIII человека, указанный пептид обладает способностью связываться с молекулой МНС II класса без дальнейшего процессирования антигена. Настоящее изобретение также относится к применению таких пептидов для профилактики или суппрессии образования ингибирующих антител при гемофилии А и/или приобретенной гемофилии.
EA201070681A 2007-12-04 2008-12-03 Пептиды fviii и их применение для индукции толерантности у больных гемофилией EA019370B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0723712.6A GB0723712D0 (en) 2007-12-04 2007-12-04 Peptides
PCT/GB2008/003996 WO2009071886A1 (en) 2007-12-04 2008-12-03 Fviii peptides and their use in tolerising haemophiliacs

Publications (2)

Publication Number Publication Date
EA201070681A1 true EA201070681A1 (ru) 2010-10-29
EA019370B1 EA019370B1 (ru) 2014-03-31

Family

ID=38982965

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070681A EA019370B1 (ru) 2007-12-04 2008-12-03 Пептиды fviii и их применение для индукции толерантности у больных гемофилией

Country Status (25)

Country Link
US (1) US8445448B2 (ru)
EP (1) EP2227488B3 (ru)
JP (2) JP5501245B2 (ru)
KR (1) KR101519840B1 (ru)
CN (2) CN101889024B (ru)
AU (1) AU2008332968B2 (ru)
BR (1) BRPI0820143A2 (ru)
CA (2) CA3005013C (ru)
CY (1) CY1115168T1 (ru)
DK (1) DK2227488T6 (ru)
EA (1) EA019370B1 (ru)
EC (1) ECSP10010327A (ru)
ES (1) ES2458315T7 (ru)
GB (1) GB0723712D0 (ru)
HR (1) HRP20140344T4 (ru)
IL (1) IL205780A (ru)
MX (1) MX2010006084A (ru)
MY (1) MY150995A (ru)
NZ (1) NZ585217A (ru)
PL (1) PL2227488T6 (ru)
PT (1) PT2227488E (ru)
SI (1) SI2227488T1 (ru)
UA (1) UA101003C2 (ru)
WO (1) WO2009071886A1 (ru)
ZA (1) ZA201002997B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9938329B2 (en) 2013-08-06 2018-04-10 Apitope International Nv Peptides

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7863701A (en) 2000-08-21 2002-03-04 Univ Bristol Peptide selection method
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII
AU2009264282B2 (en) * 2008-06-24 2013-04-18 Octapharma Ag A process of purifying coagulation factor VIII
GB0908515D0 (en) * 2009-05-18 2009-06-24 Apitope Technology Bristol Ltd Peptide
JPWO2010147145A1 (ja) * 2009-06-16 2012-12-06 学校法人東海大学 抗グラム陰性菌剤
DK2632479T3 (en) * 2010-10-27 2017-08-07 Baxalta GmbH FVIII PEPTIDES FOR IMMUNT TOLERANCE INDUCTION AND IMMUNODIAGNOSTICS
CN104254614A (zh) 2012-01-12 2014-12-31 比奥根艾迪克Ma公司 降低经受因子viii疗法的个体中针对因子viii的免疫原性的方法
LT2917232T (lt) * 2012-11-12 2017-06-26 Apitope International Nv Iš faktoriaus vii kilę peptidai, skirti naudoti hemofilijos gydymui
CA3007262A1 (en) 2015-12-03 2017-06-08 Lucas James Thompson Modified chimeric receptors and related compositions and methods
CN110520149A (zh) 2016-12-02 2019-11-29 比奥维拉迪维治疗股份有限公司 诱导对凝血因子的免疫耐受性的方法
US12077607B2 (en) * 2021-09-23 2024-09-03 University Of Utah Research Foundation Functional and therapeutic effects of PAR4 cleavage by cathepsin G

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE902211A1 (en) 1989-06-20 1991-01-16 Scripps Clinic Res The phospholipid binding domain of factor viii
PT988056E (pt) * 1997-01-22 2003-09-30 Univ Texas Metodos e composicoes de factor tecidual para o tratamento da coagulacao e de tumores
AU7863701A (en) * 2000-08-21 2002-03-04 Univ Bristol Peptide selection method
WO2002060917A2 (en) * 2000-12-01 2002-08-08 Regents Of The University Of Minnesota Method to treat hemophilia
CN100522242C (zh) * 2001-02-19 2009-08-05 默克专利有限公司 具有降低的免疫原性的人工蛋白质
AU2002312660A1 (en) 2001-05-31 2002-12-16 D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
EP1495052B9 (en) * 2002-04-18 2009-12-16 MERCK PATENT GmbH Modified factor viii
ES2567634T3 (es) * 2004-02-09 2016-04-25 Human Genome Sciences, Inc. Proteínas de fusión de albúmina
WO2006003183A1 (de) 2004-07-02 2006-01-12 Alois Jungbauer Peptide zur blockierung von fviii-inhibitoren
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9938329B2 (en) 2013-08-06 2018-04-10 Apitope International Nv Peptides
RU2676149C2 (ru) * 2013-08-06 2018-12-26 Эпитоп Интернэшнл Нв Пептиды
US10730919B2 (en) 2013-08-06 2020-08-04 Apitope International Nv Peptides

Also Published As

Publication number Publication date
KR101519840B1 (ko) 2015-05-18
ES2458315T3 (es) 2014-04-30
SI2227488T1 (sl) 2014-06-30
MX2010006084A (es) 2010-06-23
BRPI0820143A2 (pt) 2015-05-12
UA101003C2 (ru) 2013-02-25
EP2227488A1 (en) 2010-09-15
IL205780A (en) 2015-06-30
HRP20140344T1 (en) 2014-05-09
PT2227488E (pt) 2014-04-21
EP2227488B1 (en) 2014-01-22
CA3005013A1 (en) 2009-06-11
NZ585217A (en) 2012-11-30
CN103709234A (zh) 2014-04-09
PL2227488T3 (pl) 2014-07-31
CY1115168T1 (el) 2016-12-14
CN103709234B (zh) 2017-01-18
EA019370B1 (ru) 2014-03-31
MY150995A (en) 2014-03-31
ES2458315T7 (es) 2015-02-18
PL2227488T6 (pl) 2015-04-30
DK2227488T3 (da) 2014-04-22
HRP20140344T4 (hr) 2015-07-31
JP2011505414A (ja) 2011-02-24
US8445448B2 (en) 2013-05-21
ZA201002997B (en) 2011-07-27
HK1144292A1 (en) 2011-02-11
AU2008332968A1 (en) 2009-06-11
CA2707559A1 (en) 2009-06-11
CA3005013C (en) 2021-11-16
GB0723712D0 (en) 2008-01-16
US20100323966A1 (en) 2010-12-23
CN101889024A (zh) 2010-11-17
ECSP10010327A (es) 2010-09-30
JP2014088440A (ja) 2014-05-15
KR20100087346A (ko) 2010-08-04
DK2227488T6 (en) 2015-02-16
CN101889024B (zh) 2014-04-23
CA2707559C (en) 2018-07-03
EP2227488B3 (en) 2014-11-19
IL205780A0 (en) 2010-11-30
JP6063402B2 (ja) 2017-01-18
JP5501245B2 (ja) 2014-05-21
WO2009071886A1 (en) 2009-06-11
AU2008332968B2 (en) 2014-03-20

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU