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EA200971143A1 - BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS FOR THEIR RECEIVING AND APPLICATION - Google Patents

BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS FOR THEIR RECEIVING AND APPLICATION

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Publication number
EA200971143A1
EA200971143A1 EA200971143A EA200971143A EA200971143A1 EA 200971143 A1 EA200971143 A1 EA 200971143A1 EA 200971143 A EA200971143 A EA 200971143A EA 200971143 A EA200971143 A EA 200971143A EA 200971143 A1 EA200971143 A1 EA 200971143A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
compounds
positive allosteric
allosteric modulators
benzamide
Prior art date
Application number
EA200971143A
Other languages
Russian (ru)
Inventor
П. Джеффри Конн
Крейг У. Линдсли
Чарльз Дэвид Уивер
Элис Л. Родригес
Коллин М. Нисвендер
Кэрри К. Джоунс
Ричард Уилльямс
Original Assignee
Вандербилт Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вандербилт Юниверсити filed Critical Вандербилт Юниверсити
Publication of EA200971143A1 publication Critical patent/EA200971143A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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  • Pyridine Compounds (AREA)

Abstract

В одном аспекте изобретение относится к соединениям, в том числе производным бензамида и циклическим производным бензамида, которые можно применять в качестве позитивных аллостерических модуляторов метаботропного глутаматного рецептора подтипа 5 (mGluR5); синтетическим способам получения соединений; фармацевтическим композициям, содержащим эти соединения; и способам лечения неврологических и психических заболеваний, связанных с глутаматной дисфункцией, путем применения таких соединений и композиций. Настоящий реферат предназначен в качестве обзора, представленного в целях исследования в конкретной области, техники и не ограничивает настоящего изобретения.In one aspect, the invention relates to compounds, including benzamide derivatives and cyclic benzamide derivatives, which can be used as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for producing compounds; pharmaceutical compositions containing these compounds; and methods of treating neurological and mental diseases associated with glutamate dysfunction, by applying such compounds and compositions. This abstract is intended as a review presented for the purpose of research in a specific field of technology and does not limit the present invention.

EA200971143A 2007-06-03 2008-06-03 BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS FOR THEIR RECEIVING AND APPLICATION EA200971143A1 (en)

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