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EA200970916A1 - Соединения 5,6-дигидро-1н-пиридин-2-она - Google Patents

Соединения 5,6-дигидро-1н-пиридин-2-она

Info

Publication number
EA200970916A1
EA200970916A1 EA200970916A EA200970916A EA200970916A1 EA 200970916 A1 EA200970916 A1 EA 200970916A1 EA 200970916 A EA200970916 A EA 200970916A EA 200970916 A EA200970916 A EA 200970916A EA 200970916 A1 EA200970916 A1 EA 200970916A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
pyridin
digidro
dihydro
pharmaceutical compositions
Prior art date
Application number
EA200970916A
Other languages
English (en)
Other versions
EA017685B1 (ru
Inventor
Чинх Виет Тран
Франк Рюбзам
Дуглас Эрик Мерфи
Питер Драгович
Юэфэнь Чжоу
Лицзянь Чэнь
Дэвид Кучера
Фритц Блаттер
Мартин Фиртельхаус
Original Assignee
Анадис Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39831340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200970916(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Анадис Фармасьютикалз, Инк. filed Critical Анадис Фармасьютикалз, Инк.
Publication of EA200970916A1 publication Critical patent/EA200970916A1/ru
Publication of EA017685B1 publication Critical patent/EA017685B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Изобретение относится к соединениям 5,6-дигидро-1H-пиридин-2-она и фармацевтическим композициям, содержащим такие соединения, которые могут быть использованы для лечения инфекций вируса гепатита С.
EA200970916A 2007-04-03 2008-04-02 Соединения 5,6-дигидро-1н-пиридин-2-она EA017685B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90747807P 2007-04-03 2007-04-03
PCT/US2008/059164 WO2008124450A1 (en) 2007-04-03 2008-04-02 5,6-dihydro-1h-pyridin-2-one compounds

Publications (2)

Publication Number Publication Date
EA200970916A1 true EA200970916A1 (ru) 2010-04-30
EA017685B1 EA017685B1 (ru) 2013-02-28

Family

ID=39831340

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970916A EA017685B1 (ru) 2007-04-03 2008-04-02 Соединения 5,6-дигидро-1н-пиридин-2-она

Country Status (22)

Country Link
US (6) US7939524B2 (ru)
EP (1) EP2129224B1 (ru)
JP (2) JP5739662B2 (ru)
KR (1) KR101542516B1 (ru)
CN (2) CN104086540B (ru)
AR (1) AR065927A1 (ru)
AU (1) AU2008237364B2 (ru)
BR (1) BRPI0809685A2 (ru)
CA (1) CA2682584C (ru)
CL (1) CL2008000959A1 (ru)
EA (1) EA017685B1 (ru)
ES (1) ES2578302T3 (ru)
IL (2) IL201312A (ru)
MX (1) MX2009010564A (ru)
MY (1) MY157961A (ru)
NZ (1) NZ580445A (ru)
PE (1) PE20090220A1 (ru)
TN (1) TN2009000398A1 (ru)
TW (2) TWI481588B (ru)
UA (1) UA100120C2 (ru)
WO (1) WO2008124450A1 (ru)
ZA (1) ZA200907673B (ru)

Cited By (1)

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RU2838316C1 (ru) * 2024-09-11 2025-04-14 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) Способ получения эндо-3,3а,4,4а,5,5а,6,6а-октагидро-1,3-диоксо-4,6-этеноциклопроп[f]-фурана

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UA100120C2 (en) 2007-04-03 2012-11-26 Анадис Фармасьютикалз, Инк. 5,6-dihydro-1h-pyridin-2-one compounds
WO2009152166A1 (en) * 2008-06-10 2009-12-17 Anadys Pharmaceuticals, Inc. [1,2,4]thiadiazine 1,1-dioxide compounds
TW201026675A (en) * 2008-10-09 2010-07-16 Anadys Pharmaceuticals Inc 5,6-dihydro-1H-pyridin-2-one compounds
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Publication number Priority date Publication date Assignee Title
RU2838316C1 (ru) * 2024-09-11 2025-04-14 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) Способ получения эндо-3,3а,4,4а,5,5а,6,6а-октагидро-1,3-диоксо-4,6-этеноциклопроп[f]-фурана

Also Published As

Publication number Publication date
TW201431830A (zh) 2014-08-16
JP5739662B2 (ja) 2015-06-24
NZ580445A (en) 2012-01-12
CN101677563B (zh) 2014-06-25
MY157961A (en) 2016-08-30
AR065927A1 (es) 2009-07-08
CN104086540B (zh) 2017-04-12
WO2008124450A1 (en) 2008-10-16
US20100034773A1 (en) 2010-02-11
AU2008237364A1 (en) 2008-10-16
IL201312A0 (en) 2010-05-31
EP2129224A4 (en) 2011-01-05
HK1201822A1 (en) 2015-09-11
CN104086540A (zh) 2014-10-08
CA2682584A1 (en) 2008-10-16
PE20090220A1 (es) 2009-03-12
US20150065492A1 (en) 2015-03-05
ZA200907673B (en) 2014-04-30
US8546602B2 (en) 2013-10-01
AU2008237364B2 (en) 2014-03-06
US20120302744A1 (en) 2012-11-29
CL2008000959A1 (es) 2008-11-03
CN101677563A (zh) 2010-03-24
IL225694A (en) 2016-08-31
US8101800B2 (en) 2012-01-24
BRPI0809685A2 (pt) 2016-09-27
TWI427079B (zh) 2014-02-21
KR101542516B1 (ko) 2015-08-06
TN2009000398A1 (en) 2010-12-31
UA100120C2 (en) 2012-11-26
US20120130068A1 (en) 2012-05-24
EA017685B1 (ru) 2013-02-28
HK1137119A1 (zh) 2010-07-23
EP2129224B1 (en) 2016-03-30
JP2010523586A (ja) 2010-07-15
JP5934403B2 (ja) 2016-06-15
TW200906829A (en) 2009-02-16
US9156832B2 (en) 2015-10-13
US7939524B2 (en) 2011-05-10
EP2129224A1 (en) 2009-12-09
KR20090127437A (ko) 2009-12-11
US8765741B2 (en) 2014-07-01
TWI481588B (zh) 2015-04-21
ES2578302T3 (es) 2016-07-22
US20110166344A1 (en) 2011-07-07
CA2682584C (en) 2017-03-14
JP2015134783A (ja) 2015-07-27
IL201312A (en) 2015-05-31
US20140031346A1 (en) 2014-01-30
US8236948B2 (en) 2012-08-07
IL225694A0 (en) 2013-06-27
MX2009010564A (es) 2009-10-26

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