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EA200970578A1 - Генетические маркеры для предотвращения риска аритмии сердца - Google Patents

Генетические маркеры для предотвращения риска аритмии сердца

Info

Publication number
EA200970578A1
EA200970578A1 EA200970578A EA200970578A EA200970578A1 EA 200970578 A1 EA200970578 A1 EA 200970578A1 EA 200970578 A EA200970578 A EA 200970578A EA 200970578 A EA200970578 A EA 200970578A EA 200970578 A1 EA200970578 A1 EA 200970578A1
Authority
EA
Eurasian Patent Office
Prior art keywords
genetic markers
heart arrhythmia
prevent risk
markers
stroke
Prior art date
Application number
EA200970578A
Other languages
English (en)
Other versions
EA017529B1 (ru
Inventor
Анна Хельгадоттир
Даниель Гудбьяртссон
Original Assignee
Декоуд Дженетикс Ехф.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IS8576A external-priority patent/IS8576A/is
Application filed by Декоуд Дженетикс Ехф. filed Critical Декоуд Дженетикс Ехф.
Publication of EA200970578A1 publication Critical patent/EA200970578A1/ru
Publication of EA017529B1 publication Critical patent/EA017529B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40—Population genetics; Linkage disequilibrium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Physiology (AREA)
  • Ecology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

Изобретение относится к процедуре и способам определения подверженности к аритмии сердца, включая фибрилляцию предсердий, трепетание предсердий и инсульт, путем оценки наличия или отсутствия аллелей полиморфных маркеров, для которых обнаружена ассоциация с фибрилляцией предсердий, трепетанием предсердий и инсультом. Изобретение также относится к наборам, включающим реагенты для оценки таких маркеров, диагностическим методам, применениям и процедурам для использования таких маркеров подверженности.
EA200970578A 2006-12-05 2007-12-05 Генетические маркеры для предотвращения риска аритмии сердца EA017529B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IS8576A IS8576A (is) 2006-12-05 2006-12-05 Genetic susceptibility variants of atrial fibrillation and stroke
IS8658 2007-06-29
PCT/IS2007/000021 WO2008068780A2 (en) 2006-12-05 2007-12-05 Genetic markers for risk management of cardiac arrhythmia

Publications (2)

Publication Number Publication Date
EA200970578A1 true EA200970578A1 (ru) 2009-12-30
EA017529B1 EA017529B1 (ru) 2013-01-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970578A EA017529B1 (ru) 2006-12-05 2007-12-05 Генетические маркеры для предотвращения риска аритмии сердца

Country Status (15)

Country Link
US (2) US8637244B2 (ru)
EP (1) EP2121979B1 (ru)
JP (1) JP5646174B2 (ru)
KR (2) KR101582321B1 (ru)
AU (1) AU2007330306B2 (ru)
BR (1) BRPI0720116B8 (ru)
CA (1) CA2673123C (ru)
DK (1) DK2121979T3 (ru)
EA (1) EA017529B1 (ru)
IL (1) IL199049A (ru)
MX (1) MX2009005651A (ru)
NO (1) NO20092530L (ru)
NZ (1) NZ577805A (ru)
SG (1) SG177185A1 (ru)
WO (1) WO2008068780A2 (ru)

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RU2664430C1 (ru) * 2017-12-14 2018-08-17 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития инсульта у мужчин на основе генетического тестирования
CN109324189B (zh) * 2018-08-15 2021-10-01 泰达国际心血管病医院 多蛋白组合物的应用及先天性心脏病筛查试剂盒
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Also Published As

Publication number Publication date
WO2008068780A3 (en) 2008-10-09
CA2673123A1 (en) 2008-06-12
CA2673123C (en) 2019-04-30
EP2121979A2 (en) 2009-11-25
KR101582321B1 (ko) 2016-01-05
EA017529B1 (ru) 2013-01-30
BRPI0720116B8 (pt) 2021-07-27
DK2121979T3 (en) 2017-09-25
AU2007330306B2 (en) 2013-10-24
NZ577805A (en) 2012-09-28
IL199049A (en) 2014-09-30
SG177185A1 (en) 2012-01-30
JP5646174B2 (ja) 2014-12-24
KR20090087494A (ko) 2009-08-17
US20090325163A1 (en) 2009-12-31
NO20092530L (no) 2009-09-03
US20140227693A1 (en) 2014-08-14
MX2009005651A (es) 2009-06-08
JP2010511404A (ja) 2010-04-15
US8637244B2 (en) 2014-01-28
BRPI0720116B1 (pt) 2018-05-02
KR20150113216A (ko) 2015-10-07
BRPI0720116A2 (pt) 2014-01-14
EP2121979B1 (en) 2017-07-12
AU2007330306A1 (en) 2008-06-12
WO2008068780A2 (en) 2008-06-12

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