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EA200970469A1 - Антитела-агонисты рецептора trkb и их применение - Google Patents

Антитела-агонисты рецептора trkb и их применение

Info

Publication number
EA200970469A1
EA200970469A1 EA200970469A EA200970469A EA200970469A1 EA 200970469 A1 EA200970469 A1 EA 200970469A1 EA 200970469 A EA200970469 A EA 200970469A EA 200970469 A EA200970469 A EA 200970469A EA 200970469 A1 EA200970469 A1 EA 200970469A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
agonists
application
trkb receptor
individual
Prior art date
Application number
EA200970469A
Other languages
English (en)
Inventor
Янь Ван
Стивен Б. Коэн
Марк Насофф
Original Assignee
АйАрЭм ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by АйАрЭм ЭлЭлСи filed Critical АйАрЭм ЭлЭлСи
Publication of EA200970469A1 publication Critical patent/EA200970469A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к антителам-агонистам рецептора TrkB, к фармацевтической композиции, содержащей терапевтически эффективное количество указанного антитела и фармацевтический носитель, и к способу снижения уровней глюкозы в крови и/или массы тела у индивидуума, нуждающегося в этом, причем способ включает введение индивидууму терапевтически эффективного количества указанного антитела.
EA200970469A 2006-11-09 2007-11-06 Антитела-агонисты рецептора trkb и их применение EA200970469A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85816906P 2006-11-09 2006-11-09
PCT/US2007/083774 WO2008058127A2 (en) 2006-11-09 2007-11-06 Agonist trkb antibodies and uses thereof

Publications (1)

Publication Number Publication Date
EA200970469A1 true EA200970469A1 (ru) 2010-04-30

Family

ID=39365312

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970469A EA200970469A1 (ru) 2006-11-09 2007-11-06 Антитела-агонисты рецептора trkb и их применение

Country Status (27)

Country Link
US (1) US20100150914A1 (ru)
EP (1) EP2087007A2 (ru)
JP (1) JP2010509354A (ru)
KR (1) KR20090088896A (ru)
CN (1) CN101573381A (ru)
AR (1) AR063640A1 (ru)
AU (1) AU2007316418A1 (ru)
BR (1) BRPI0719000A2 (ru)
CA (1) CA2669205A1 (ru)
CL (1) CL2007003236A1 (ru)
CO (1) CO6180432A2 (ru)
CR (1) CR10779A (ru)
DO (1) DOP2009000102A (ru)
EA (1) EA200970469A1 (ru)
EC (1) ECSP099392A (ru)
IL (1) IL198468A0 (ru)
MA (1) MA30922B1 (ru)
MX (1) MX2009004881A (ru)
NI (1) NI200900081U (ru)
NO (1) NO20092217L (ru)
PE (1) PE20081168A1 (ru)
RU (1) RU2009121641A (ru)
SM (1) SMAP200900040A (ru)
TN (1) TN2009000181A1 (ru)
TW (1) TW200829270A (ru)
WO (1) WO2008058127A2 (ru)
ZA (1) ZA200902943B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0817812A2 (pt) * 2007-10-23 2015-04-14 Novartis Ag Uso de anticorpos trkb para o tratamento de distúrbios respiratórios
US8642035B2 (en) * 2008-01-17 2014-02-04 Irm Llc Anti-TrkB antibodies
WO2010106187A2 (en) * 2009-03-20 2010-09-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Inhibitors of cathepsin s for prevention or treatment of obesity-associated disorders
GB2491106A (en) * 2011-05-18 2012-11-28 Univ Basel Antibodies against tropomyosin-related kinase B receptors
WO2013083826A2 (en) * 2011-12-09 2013-06-13 Novo Nordisk A/S Glp-1 agonists
CN102901815B (zh) * 2012-11-05 2014-10-22 武汉远征世纪制药有限公司 一种检测TrkB受体816/817位酪氨酸位点活性的ELISA试剂盒及其使用方法
CN102944674B (zh) * 2012-11-05 2014-10-22 武汉远征世纪制药有限公司 一种检测TrkB受体pan-Tyr位点活性的ELISA试剂盒及其使用方法
US10392438B2 (en) 2014-05-16 2019-08-27 Pfizer Inc. Bispecific antibodies
CN104524568B (zh) * 2015-01-08 2018-04-20 中国人民解放军第二军医大学 一种治疗肥胖症的药物组合物及其应用
KR20180037994A (ko) * 2015-07-28 2018-04-13 오토노미, 인코포레이티드 TrkB 또는 TrkC 아고니스트 조성물 및 귀 병태의 치료 방법
AU2016356877A1 (en) 2015-11-17 2018-05-10 Glaxosmithkline Intellectual Property Development Limited Binding agonists for treatment of neurological and other disorders
US9914781B1 (en) 2016-11-08 2018-03-13 Glaxosmithkline Intellectual Property Development Limited Binding agonist for treatment of neurological and other disorders
WO2018195008A1 (en) * 2017-04-21 2018-10-25 Mellitus, Llc Methods and antibodies for diabetes-related applications
US10793634B2 (en) 2017-06-09 2020-10-06 Boehringer Ingelheim International Gmbh Anti-TrkB antibodies
EP3717514A1 (en) * 2017-11-30 2020-10-07 Regeneron Pharmaceuticals, Inc. Anti-trkb monoclonal antibodies and methods of use
CN112272677B (zh) * 2018-02-26 2024-10-29 米纳瓦生物技术公司 使用抗muc1＊抗体的诊断方法
CN110818797B (zh) * 2018-08-09 2022-11-04 东莞市朋志生物科技有限公司 一种抗人ca153蛋白的重组抗体
US12110335B2 (en) 2020-10-21 2024-10-08 Boehringer Ingelheim International Gmbh Bispecific anti-VEGF and anti-TrkB binding molecules for the treatment of eye diseases
WO2023125485A1 (en) * 2021-12-28 2023-07-06 4B Technologies (Beijing) Co., Limited TrkB ANTIBODY AND APPLICATION THEREOF

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE768377T1 (de) 1988-09-02 1998-01-02 Dyax Corp Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
WO1991010737A1 (en) 1990-01-11 1991-07-25 Molecular Affinities Corporation Production of antibodies using gene libraries
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DE69233750D1 (de) 1991-04-10 2009-01-02 Scripps Research Inst Bibliotheken heterodimerer Rezeptoren mittels Phagemiden
US5885793A (en) 1991-12-02 1999-03-23 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
WO1995015982A2 (en) 1993-12-08 1995-06-15 Genzyme Corporation Process for generating specific antibodies
ATE243745T1 (de) 1994-01-31 2003-07-15 Univ Boston Bibliotheken aus polyklonalen antikörpern
US5601820A (en) * 1994-07-07 1997-02-11 Children's Hospital Of Philadelphia Compositions and methods of making and using human full length TRK-B
PA8678401A1 (es) * 2005-06-06 2009-05-15 Wyeth Corp Anticuerpos monoclonales anti-trkb y sus usos
WO2007088479A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkb antagonist
JP2009528985A (ja) * 2006-02-02 2009-08-13 ライナット ニューロサイエンス コーポレイション ｔｒｋＢアゴニストを投与することにより望まれない体重減少または摂食障害を治療する方法

Also Published As

Publication number Publication date
ECSP099392A (es) 2009-07-31
RU2009121641A (ru) 2010-12-20
SMAP200900040A (it) 2010-01-19
MX2009004881A (es) 2009-05-21
CO6180432A2 (es) 2010-07-19
TN2009000181A1 (en) 2010-10-18
WO2008058127A9 (en) 2008-08-21
NO20092217L (no) 2009-06-09
CL2007003236A1 (es) 2008-06-13
ZA200902943B (en) 2010-05-26
WO2008058127A2 (en) 2008-05-15
TW200829270A (en) 2008-07-16
AU2007316418A1 (en) 2008-05-15
EP2087007A2 (en) 2009-08-12
DOP2009000102A (es) 2010-10-31
AR063640A1 (es) 2009-02-04
IL198468A0 (en) 2011-08-01
US20100150914A1 (en) 2010-06-17
NI200900081U (es) 2010-03-16
CR10779A (es) 2009-07-03
JP2010509354A (ja) 2010-03-25
WO2008058127A3 (en) 2008-10-02
PE20081168A1 (es) 2008-09-22
KR20090088896A (ko) 2009-08-20
BRPI0719000A2 (pt) 2013-12-10
MA30922B1 (fr) 2009-11-02
CA2669205A1 (en) 2008-05-15
CN101573381A (zh) 2009-11-04

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