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EA200970158A1 - Производные хинуклидина в качестве антагонистов м3 - Google Patents

Производные хинуклидина в качестве антагонистов м3

Info

Publication number
EA200970158A1
EA200970158A1 EA200970158A EA200970158A EA200970158A1 EA 200970158 A1 EA200970158 A1 EA 200970158A1 EA 200970158 A EA200970158 A EA 200970158A EA 200970158 A EA200970158 A EA 200970158A EA 200970158 A1 EA200970158 A1 EA 200970158A1
Authority
EA
Eurasian Patent Office
Prior art keywords
optionally substituted
antagonists
thienyl
substituted phenyl
quinuclidine derivatives
Prior art date
Application number
EA200970158A
Other languages
English (en)
Other versions
EA017698B1 (ru
Inventor
Габриэле Амари
Андреа Рицци
Риккардо Патаккини
Валентина Ченакки
Джино Виллетти
Хуан Лоренсо Катена Руис
Исабель Масип Масип
Original Assignee
Кьези Фармачеутичи С. П. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кьези Фармачеутичи С. П. А. filed Critical Кьези Фармачеутичи С. П. А.
Publication of EA200970158A1 publication Critical patent/EA200970158A1/ru
Publication of EA017698B1 publication Critical patent/EA017698B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Производное хинуклидина общей формулы (I) в виде отдельных энантиомеров или их смесей, применяемое в производстве лекарственного средства для предотвращения или лечения респираторных заболеваний, таких как астма, хроническое обструктивное заболевание легких (ХОЗЛ), хронический бронхит, кашель и эмфизема, где Rвыбирают из H, F, Cl, Br, I и (C-С)-алкила; Rявляется необязательно замещенным 2- или 3-тиенилом или замещенным фенилом; Rявляется (CH)-CORили (СН)-S(О)R, где Rявляется необязательно замещенным фенилом или необязательно замещенным 2- или 3-тиенилом; n равно 0, 1 или 2; Xявляется фармацевтически приемлемым анионом.
EA200970158A 2006-07-26 2007-07-23 Производные хинуклидина в качестве антагонистов м3 EA017698B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06117883A EP1882691A1 (en) 2006-07-26 2006-07-26 Quinuclidine derivatives as M3 antagonists
PCT/EP2007/057585 WO2008012290A2 (en) 2006-07-26 2007-07-23 Quinuclidine derivatives as m3 antagonists

Publications (2)

Publication Number Publication Date
EA200970158A1 true EA200970158A1 (ru) 2009-06-30
EA017698B1 EA017698B1 (ru) 2013-02-28

Family

ID=37890216

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970158A EA017698B1 (ru) 2006-07-26 2007-07-23 Производные хинуклидина в качестве антагонистов м3

Country Status (16)

Country Link
US (1) US7838534B2 (ru)
EP (2) EP1882691A1 (ru)
JP (1) JP5331688B2 (ru)
KR (1) KR20090033443A (ru)
CN (1) CN101490049A (ru)
AR (1) AR062104A1 (ru)
AU (1) AU2007278231B2 (ru)
BR (1) BRPI0713826A2 (ru)
CA (1) CA2658649A1 (ru)
CL (1) CL2007002159A1 (ru)
EA (1) EA017698B1 (ru)
MX (1) MX2009000999A (ru)
PE (1) PE20080407A1 (ru)
TW (1) TW200817398A (ru)
WO (1) WO2008012290A2 (ru)
ZA (1) ZA200901124B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1345937T1 (sl) 2000-12-22 2006-02-28 Almirall Prodesfarma Ag Derivati kinulidinkarbamata in njihova uporaba kot M3 antagonisti
ES2246170B1 (es) * 2004-07-29 2007-04-01 Almirall Prodesfarma, S.A. Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
EP2080507A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Pharmaceutical formulations comprising an anticholinergic drug
EP2080523A1 (en) 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Compositions comprising an antimuscarinic and a long-acting beta-agonist
EP2080508A1 (en) 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Dry powder formulation comprising an anticholinergic drug
EP2154136A1 (en) * 2008-08-08 2010-02-17 CHIESI FARMACEUTICI S.p.A. Quinuclidine carbonate derivatives and medicinal compositions thereof
EP2206712A1 (en) 2008-12-23 2010-07-14 CHIESI FARMACEUTICI S.p.A. "Alkaloid aminoester derivatives and medicinal composition thereof"
KR20130087405A (ko) 2010-06-22 2013-08-06 키에시 파르마슈티시 엣스. 피. 에이. 알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
KR20130087406A (ko) 2010-06-22 2013-08-06 키에시 파르마슈티시 엣스. 피. 에이. 알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
ES2545812T3 (es) 2010-06-22 2015-09-16 Chiesi Farmaceutici S.P.A. Derivados aminoéster de alcaloides y composición medicinal de estos
NZ604983A (en) * 2010-06-22 2014-07-25 Chiesi Farma Spa Dry powder formulation comprising an antimuscarinic drug
CN103221390B (zh) 2010-11-26 2015-06-03 奇斯药制品公司 甘氨酸衍生物及其医药组合物
US20120220557A1 (en) 2011-02-17 2012-08-30 Chiesi Farmaceutici S.P.A. Liquid propellant-free formulation comprising an antimuscarinic drug
WO2012146515A1 (en) 2011-04-29 2012-11-01 Chiesi Farmaceutici S.P.A. Alkaloid ester and carbamate derivatives and medicinal compositions thereof
WO2013098145A1 (en) 2011-12-30 2013-07-04 Chiesi Farmaceutici S.P.A. Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1227251C (zh) * 2000-06-27 2005-11-16 S·A·L·V·A·T·实验室有限公司 由芳基烷基胺得到的氨基甲酸酯
SI1345937T1 (sl) * 2000-12-22 2006-02-28 Almirall Prodesfarma Ag Derivati kinulidinkarbamata in njihova uporaba kot M3 antagonisti
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
CA2470956C (en) * 2001-12-20 2011-08-02 Laboratorios S.A.L.V.A.T., S.A. 1-alkyl-1-azoniabicyclo[2.2.2]octane carbamate derivatives and their use as muscarinic receptor antagonists
ES2203327B1 (es) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
EA017698B1 (ru) 2013-02-28
TW200817398A (en) 2008-04-16
WO2008012290A2 (en) 2008-01-31
EP1882691A1 (en) 2008-01-30
US20080039493A1 (en) 2008-02-14
WO2008012290A3 (en) 2008-03-13
CN101490049A (zh) 2009-07-22
EP2049533A2 (en) 2009-04-22
JP2009544659A (ja) 2009-12-17
AU2007278231A1 (en) 2008-01-31
MX2009000999A (es) 2009-04-15
KR20090033443A (ko) 2009-04-03
JP5331688B2 (ja) 2013-10-30
ZA200901124B (en) 2010-05-26
US7838534B2 (en) 2010-11-23
AU2007278231B2 (en) 2012-08-16
PE20080407A1 (es) 2008-06-17
AR062104A1 (es) 2008-10-15
CL2007002159A1 (es) 2008-01-04
BRPI0713826A2 (pt) 2015-05-12
CA2658649A1 (en) 2008-01-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU