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EA200900821A1 - Производные 1-аминометил-l-фенилциклогексана как ингибиторы дпп-iv (дипептидилпептидазы-iv) - Google Patents

Производные 1-аминометил-l-фенилциклогексана как ингибиторы дпп-iv (дипептидилпептидазы-iv)

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Publication number
EA200900821A1
EA200900821A1 EA200900821A EA200900821A EA200900821A1 EA 200900821 A1 EA200900821 A1 EA 200900821A1 EA 200900821 A EA200900821 A EA 200900821A EA 200900821 A EA200900821 A EA 200900821A EA 200900821 A1 EA200900821 A1 EA 200900821A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dpp
phenylciclogexane
aminomethil
dipeptidylpeptidase
inhibitors
Prior art date
Application number
EA200900821A
Other languages
English (en)
Inventor
Даниель Каспар Бэшлин
Рихард Зедрани
Штефани Флор
Кенджи Намото
Финтон Сирокен
Франсуа Жессьер
Гарри Фентон
Манди Кристин Бесуик
Дейвид Эдуард Кларк
Бохдан Вашкович
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA200900821A1 publication Critical patent/EA200900821A1/ru

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Abstract

В заявке описаны соединения формулы (I)в которой V, W, X, Y, Z, R, R, R, R, Rи m являются такими, как определено в описании, и их фармацевтически приемлемые соли или пролекарства. Соединения могут быть применимы для лечения или предупреждения различных заболеваний и патологических состояний, в которых участвует дипептидилпептидаза-IV (ДПП-IV).
EA200900821A 2006-12-22 2007-12-20 Производные 1-аминометил-l-фенилциклогексана как ингибиторы дпп-iv (дипептидилпептидазы-iv) EA200900821A1 (ru)

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EP06127001 2006-12-22
PCT/EP2007/011304 WO2008077597A1 (en) 2006-12-22 2007-12-20 1-aminomethyl- l- phenyl- cyclohexane derivatives as ddp-iv inhibitors

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Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2069312B1 (en) 2006-07-25 2012-11-07 Cephalon, Inc. Pyridizinone derivatives
RU2464262C2 (ru) * 2007-03-30 2012-10-20 Санофи-Авентис Пиримидингидразидные соединения как ингибиторы pgds
PL2280941T3 (pl) * 2008-03-27 2015-10-30 Gruenenthal Gmbh (Hetero-)arylowe pochodne cykloheksanu
EP2502907B1 (de) 2008-03-27 2018-08-29 Grünenthal GmbH Substituierte 4-Aminocyclohexan-Derivate
CA2738314C (en) * 2008-09-23 2017-01-10 Georgetown University 1,2-benzisothiazolinone and isoindolinone derivatives
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8877795B2 (en) 2010-05-07 2014-11-04 The Board Of Trustees Of The Leland Stanford Junior University Identification of stabilizers of multimeric proteins
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
US9120752B2 (en) 2010-07-16 2015-09-01 Purdue Pharma, L.P. Pyridine compounds as sodium channel blockers
WO2013025897A1 (en) 2011-08-16 2013-02-21 Georgetown University Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013072705A1 (en) 2011-11-18 2013-05-23 Heptares Therapeutics Limited Muscarinic m1 receptor agonists
AU2013203824A1 (en) 2012-03-16 2013-10-03 Purdue Pharma L.P. Substituted pyridines and pryimidines as sodium channel blockers
US20150297573A1 (en) 2012-10-24 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
US9714252B2 (en) 2012-12-20 2017-07-25 Purdue Pharma L.P. Cyclic sulfonamides as sodium channel blockers
WO2014193528A1 (en) * 2013-04-29 2014-12-04 Anovel Pharmaceuticals, Llc Amorphous dosage forms and methods
US9981928B2 (en) 2013-06-20 2018-05-29 Bayer Cropscience Aktiengesellschaft Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
US10730866B2 (en) 2014-04-07 2020-08-04 Purdue Pharma L.P. Indole derivatives and use thereof
US20160045609A1 (en) 2014-08-14 2016-02-18 Mamoun M. Alhamadsheh Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
ES2805743T3 (es) 2015-03-24 2021-02-15 Inst Nat Sante Rech Med Método y composición farmacéutica para uso en el tratamiento de la diabetes
CN107922345B (zh) * 2015-07-01 2021-03-23 圣诺康生命科学公司 作为碳酸酐酶抑制剂的芳基磺酰胺化合物及其治疗用途
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
WO2017070708A1 (en) 2015-10-23 2017-04-27 Array Biopharma, Inc. 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
US10414774B2 (en) 2016-08-15 2019-09-17 Merck Sharp & Dohme Corp. Compound useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolc disease
EP3496715B1 (en) 2016-08-15 2021-11-03 Merck Sharp & Dohme Corp. Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease
CN106467477A (zh) * 2016-08-26 2017-03-01 天津雅奥科技发展有限公司 一种合成化合物（1‑环丙基‑1‑氰基‑4‑环己酮）的新方法
US10259787B2 (en) 2016-10-14 2019-04-16 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
GB201617454D0 (en) * 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
CN110381940B (zh) 2017-02-17 2023-07-21 文涵治疗有限公司 Ag-10的制备方法、其中间体及其盐
SG11202009073WA (en) 2018-03-23 2020-10-29 Eidos Therapeutics Inc Methods of treating ttr amyloidosis using ag10
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
NZ774039A (en) 2018-08-17 2025-03-28 Eidos Therapeutics Inc Formulations of ag10
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
AR117169A1 (es) * 2018-11-28 2021-07-14 Bayer Ag (tio)amidas de piridazina como compuestos fungicidas
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
US12180207B2 (en) 2018-12-19 2024-12-31 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of FGFR tyrosine kinases
WO2020131674A1 (en) 2018-12-19 2020-06-25 Array Biopharma Inc. 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer
CA3134613A1 (en) 2019-04-02 2020-10-08 Aligos Therapeutics, Inc. Compounds targeting prmt5
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
EP3858810A1 (en) * 2020-02-03 2021-08-04 Esteve Pharmaceuticals, S.A. Dialkylaminoarylcycloalkylamide derivatives having multimodal activity against pain
EP4458834A3 (en) 2020-02-07 2025-01-15 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
EP4337323A4 (en) * 2021-05-14 2025-07-09 Bm Pharma Consulting Pty Ltd BICYCLIC HETEROCYCLIC COMPOUNDS FOR THE PROPHYLAXIS AND TREATMENT OF VIRAL INFECTIONS
WO2022261210A1 (en) * 2021-06-08 2022-12-15 Quanta Therapeutics, Inc. Kras modulators and uses thereof
IL314812A (en) 2022-02-09 2024-10-01 Quanta Therapeutics Inc Kras modulators and uses thereof
CN114920747B (zh) * 2022-05-16 2023-07-18 江苏医药职业学院 一种合成氟唑帕利中间体的方法
CN119604501A (zh) 2022-05-25 2025-03-11 光达治疗公司 基于嘧啶的调节剂及其用途
CN115181569B (zh) * 2022-07-07 2023-05-09 湖北兴福电子材料股份有限公司 一种氧化硅的选择性蚀刻液
WO2024169952A1 (en) 2023-02-16 2024-08-22 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE616646A (ru) *
JPS5010309B1 (ru) * 1969-12-24 1975-04-19
US4292323A (en) * 1980-03-31 1981-09-29 Schering Corporation Phenyl-1,2,3,4-tetrahydrocarbazoles and use thereof
EP0633775B1 (en) * 1992-04-02 2000-05-31 Smithkline Beecham Corporation Compounds useful for treating inflammatory diseases and for inhibiting production of tumor necrosis factor
US6060484A (en) * 1996-05-06 2000-05-09 Eli Lilly And Company Anti-viral method
GB9621789D0 (en) * 1996-10-18 1996-12-11 Lilly Industries Ltd Pharmaceutical compounds
US6518289B1 (en) * 1997-12-16 2003-02-11 Pfizer, Inc. 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
US6632836B1 (en) * 1998-10-30 2003-10-14 Merck & Co., Inc. Carbocyclic potassium channel inhibitors
GB0012214D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
BR0115776A (pt) * 2000-11-30 2004-01-13 Pfizer Prod Inc Combinações de agonistas de gaba e inibidores da aldose redutase
US20020115727A1 (en) * 2000-12-04 2002-08-22 Senanayake Chris H. Synthesis, methods of using, and compositions of hydroxylated cyclobutylalkylamines
BR0208922A (pt) * 2001-04-19 2004-04-20 Warner Lambert Co Aminoácidos bicìclicos ou tricìclicos fundidos
US20030162754A1 (en) * 2001-12-17 2003-08-28 Tufts University Use of GABA and GABAB agonists
TW200307539A (en) * 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
MXPA04008175A (es) * 2002-02-22 2004-11-26 Warner Lambert Co Combinaciones de un ligando alfa-2-delta con un inhibidor selectivo de la ciclooxigenasa-2.
JPWO2005037269A1 (ja) * 2003-10-21 2006-12-28 住友製薬株式会社 新規ピペリジン誘導体
US7772232B2 (en) * 2004-04-15 2010-08-10 Bristol-Myers Squibb Company Quinazolinyl compounds as inhibitors of potassium channel function
CA2565852C (en) * 2004-05-07 2010-08-10 Warner-Lambert Company Llc 3- or 4-monosubstituted phenol and thiophenol derivatives useful as h3 ligands
EP1604980A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft DPP-IV inhibitors
DE102005030213A1 (de) * 2005-06-29 2007-01-04 Robert Bosch Gmbh Fahrerinformationsvorrichtung
WO2007081857A2 (en) * 2006-01-06 2007-07-19 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors

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