[go: up one dir, main page]

EA200870565A1 - 2-ALKOXI-3,4,5-TRIHYDROXIALKYLAMIDOBENZEZEPINA, THEIR RECEIVING, THEIR COMPOSITIONS AND APPLICATION - Google Patents

2-ALKOXI-3,4,5-TRIHYDROXIALKYLAMIDOBENZEZEPINA, THEIR RECEIVING, THEIR COMPOSITIONS AND APPLICATION

Info

Publication number
EA200870565A1
EA200870565A1 EA200870565A EA200870565A EA200870565A1 EA 200870565 A1 EA200870565 A1 EA 200870565A1 EA 200870565 A EA200870565 A EA 200870565A EA 200870565 A EA200870565 A EA 200870565A EA 200870565 A1 EA200870565 A1 EA 200870565A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
trihydroxialkylamidobenzezepina
alkoxi
receiving
application
Prior art date
Application number
EA200870565A
Other languages
Russian (ru)
Inventor
Цзидун Чжан
Фредерико Нарди
Ален Коммерсон
Original Assignee
Санофи Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи Авентис filed Critical Санофи Авентис
Publication of EA200870565A1 publication Critical patent/EA200870565A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится, главным образом, к 2-алкокси-3,4,5-тригидроксиалкиламидобензазепинам, их получению, содержащим их композициям и их применению в качестве лекарственного средства, в частности в качестве противораковых агентов.The present invention relates mainly to 2-alkoxy-3,4,5-trihydroxyalkylamidobenzazepines, their preparation, compositions containing them and their use as a medicine, in particular as anticancer agents.

EA200870565A 2006-05-24 2007-05-23 2-ALKOXI-3,4,5-TRIHYDROXIALKYLAMIDOBENZEZEPINA, THEIR RECEIVING, THEIR COMPOSITIONS AND APPLICATION EA200870565A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0604733A FR2901554B1 (en) 2006-05-24 2006-05-24 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZAZEPINE, PREPARATION THEREOF, COMPOSITIONS CONTAINING SAME AND USE THEREOF
PCT/FR2007/000866 WO2007135293A2 (en) 2006-05-24 2007-05-23 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation and use thereof, and compositions containing the same

Publications (1)

Publication Number Publication Date
EA200870565A1 true EA200870565A1 (en) 2009-06-30

Family

ID=37487536

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870565A EA200870565A1 (en) 2006-05-24 2007-05-23 2-ALKOXI-3,4,5-TRIHYDROXIALKYLAMIDOBENZEZEPINA, THEIR RECEIVING, THEIR COMPOSITIONS AND APPLICATION

Country Status (24)

Country Link
US (1) US7994162B2 (en)
EP (1) EP2035387A2 (en)
JP (1) JP2009537614A (en)
KR (1) KR20090010071A (en)
CN (1) CN101454290A (en)
AR (1) AR061103A1 (en)
AU (1) AU2007253196A1 (en)
BR (1) BRPI0712925A2 (en)
CA (1) CA2649336A1 (en)
CR (1) CR10382A (en)
DO (1) DOP2007000104A (en)
EA (1) EA200870565A1 (en)
EC (1) ECSP088893A (en)
FR (1) FR2901554B1 (en)
GT (1) GT200800249A (en)
IL (2) IL194972A0 (en)
MA (1) MA30561B1 (en)
MX (1) MX2008014844A (en)
NO (1) NO20085285L (en)
PE (1) PE20080705A1 (en)
TN (1) TNSN08402A1 (en)
TW (1) TW200812971A (en)
UY (1) UY30368A1 (en)
WO (1) WO2007135293A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2878528B1 (en) 2004-11-29 2008-05-16 Aventis Pharma Sa 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDES, PREPARATION THEREOF, COMPOSITIONS CONTAINING SAME AND USE THEREOF
CN102924462B (en) * 2012-10-24 2015-01-14 华东师范大学 Method for synthesis of 1,2,3,4,5,9-substituted benzazepine compound

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4831135A (en) 1986-06-18 1989-05-16 The Regents Of The University Of California Bengamide anthelmintics
US5283241A (en) 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
GB9411841D0 (en) 1994-06-14 1994-08-03 Pharma Mar Sa New antitumoral compounds from jaspis sponge
JP2002241368A (en) 1997-02-18 2002-08-28 Shionogi & Co Ltd New benzolactam derivative and pharmaceutical composition containing the same
US6239127B1 (en) 1999-11-17 2001-05-29 Novartis Ag Certain substituted caprolactams, pharmaceutical compositions containing them and a process for their preparation
CO5140099A1 (en) 1998-11-17 2002-03-22 Novartis Ag CERTAIN SUBSTITUTED CAPROLACTAMAS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND ITS USE IN TUMORS TREATMENT
BR0110641A (en) * 2000-05-11 2003-03-18 Novartis Ag Certain substituted caprolactamic carbonates and ethers, pharmaceutical compositions containing them and their use in the treatment of tumors
AU2002217020A1 (en) 2000-11-14 2002-05-27 Novartis Ag Method for screening anti-proliferative compounds and inhibiting tumor growth
WO2002072555A1 (en) 2001-03-12 2002-09-19 Novartis Ag Process for preparing certain substituted caprolactams
JP2004262793A (en) 2003-02-28 2004-09-24 Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai Compound N-9011, production method and use thereof
MXPA06000975A (en) * 2003-07-25 2006-04-11 Novartis Ag Substituted lactams and their use as anti-cancer agents.
US7153846B2 (en) 2003-10-24 2006-12-26 Sanofi-Aventis Deutschland Gmbh Bengamide derivatives, process for preparing them, and their use
DE10349669B3 (en) 2003-10-24 2005-05-25 Aventis Pharma Deutschland Gmbh Bengamide derivatives, process for their preparation and their use
FR2878525B1 (en) 2004-11-29 2007-02-23 Aventis Pharma Sa BENGAMIDES HAVING SUBSTITUTED CAPROLACTAM CYCLE, PREPARATION METHOD, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2878528B1 (en) 2004-11-29 2008-05-16 Aventis Pharma Sa 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDES, PREPARATION THEREOF, COMPOSITIONS CONTAINING SAME AND USE THEREOF

Also Published As

Publication number Publication date
AR061103A1 (en) 2008-08-06
TNSN08402A1 (en) 2010-04-14
GT200800249A (en) 2009-05-15
KR20090010071A (en) 2009-01-28
FR2901554B1 (en) 2011-04-01
PE20080705A1 (en) 2008-07-30
WO2007135293A3 (en) 2008-05-02
DOP2007000104A (en) 2007-11-15
US7994162B2 (en) 2011-08-09
JP2009537614A (en) 2009-10-29
TW200812971A (en) 2008-03-16
US20090099152A1 (en) 2009-04-16
CN101454290A (en) 2009-06-10
IL194972A0 (en) 2009-08-03
BRPI0712925A2 (en) 2013-01-08
EP2035387A2 (en) 2009-03-18
MA30561B1 (en) 2009-07-01
CA2649336A1 (en) 2007-11-29
AU2007253196A1 (en) 2007-11-29
UY30368A1 (en) 2008-01-02
FR2901554A1 (en) 2007-11-30
CR10382A (en) 2009-02-26
MX2008014844A (en) 2009-02-17
NO20085285L (en) 2008-12-17
ECSP088893A (en) 2008-12-30
WO2007135293A2 (en) 2007-11-29
IL195148A0 (en) 2009-09-22

Similar Documents

Publication Publication Date Title
MX2007008790A (en) Substituted pyrazolo-pyridines, compositions containing them, method for the production thereof, and their use.
EA201300242A1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED ACYLANILIDES
PH12013502192A1 (en) Antibodies against human angiopoietin 2
TW200745103A (en) Substituted 7-azaindazoles, compositions containing them, production process and use
EA201070544A1 (en) NEW CLASS OF THERAPEUTIC SUBSTANCES STRENGTHENING THE DIFFUSION OF LOW MOLECULAR COMPOUNDS
EA200702329A1 (en) SUBSTITUTED PYRROPHYRIDINES CONTAINING THEIR COMPOSITIONS, METHOD OF OBTAINING AND APPLICATION
JO2721B1 (en) Artemisinin Derivative Dimers, Their preparation and their therapeutic application
DK1791571T3 (en) Radiofluorinated peptides
CR9114A (en) 2-ALCOXI-3,4,5-TRIHYDROXI-ALQUIMIDAS, ITS PREPARATION COMPOSITIONS THAT CONTAIN THEM AND ITS USE
TW200640858A (en) Substituted pyrroles, compositions containing them, method of manufacture and use
GB0615105D0 (en) Novel compounds
ATE533477T1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING IRBESARTAN
MX2007006042A (en) Bengamides with a substituted caprolactame cycle, method for the preparation thereof, compositions containing them and use thereof.
EA200870565A1 (en) 2-ALKOXI-3,4,5-TRIHYDROXIALKYLAMIDOBENZEZEPINA, THEIR RECEIVING, THEIR COMPOSITIONS AND APPLICATION
EA200870567A1 (en) DERIVATIVES 2-ALKOXI-3,4,5-TRIHYDROXIALKYLAMIDE, THEIR PRODUCTION, COMPOSITIONS, THEIR CONTAINING, AND APPLICATION
EA200870566A1 (en) 2-ALKOXI-3,4,5-TRIHYDROXIALKYLAMIDOBENZOTHIAZEPINE, THEIR RECEIVING, COMPOSITIONS CONTAINING THEM, AND APPLICATION
GB0620619D0 (en) Novel compounds
TW200633717A (en) Process for and intermediates in the preparation of canfosfamide and its salts, pharmaceutical compositions containing some intermediates, and their use as anticancer agents
EA200701227A1 (en) SUBSTITUTED INDOLES CONTAINING THEIR COMPOSITIONS, METHOD OF OBTAINING AND APPLICATION
UA35751U (en) Using the preparation "krystal-900" as a disinfecting agent in fishery