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EA200801875A1 - Антагонист cd 80 - Google Patents

Антагонист cd 80

Info

Publication number
EA200801875A1
EA200801875A1 EA200801875A EA200801875A EA200801875A1 EA 200801875 A1 EA200801875 A1 EA 200801875A1 EA 200801875 A EA200801875 A EA 200801875A EA 200801875 A EA200801875 A EA 200801875A EA 200801875 A1 EA200801875 A1 EA 200801875A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonist
cinnolin
dihydropyrazolo
difluoroethyl
benzamide
Prior art date
Application number
EA200801875A
Other languages
English (en)
Other versions
EA014101B1 (ru
Inventor
Иан Ричард Мэттьюс
Original Assignee
Медиджен Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Медиджен Лимитед filed Critical Медиджен Лимитед
Publication of EA200801875A1 publication Critical patent/EA200801875A1/ru
Publication of EA014101B1 publication Critical patent/EA014101B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Холиновая соль антагониста CD80 - 4-(6-фтор-3-оксо-1,3-дигидропиразоло[4,3-с]циннолин-2-ил)-N-(2,2-дифторэтил)бензамида обладает хорошей растворимостью в воде и поэтому удобна для использования в составе лекарственных средств.
EA200801875A 2006-02-22 2007-02-19 Антагонист cd80 EA014101B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0603522.4A GB0603522D0 (en) 2006-02-22 2006-02-22 Kinase inhibition
PCT/GB2007/000550 WO2007096588A1 (en) 2006-02-22 2007-02-19 Salt of cd 80 antagonist

Publications (2)

Publication Number Publication Date
EA200801875A1 true EA200801875A1 (ru) 2008-12-30
EA014101B1 EA014101B1 (ru) 2010-08-30

Family

ID=36178528

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801875A EA014101B1 (ru) 2006-02-22 2007-02-19 Антагонист cd80

Country Status (19)

Country Link
US (3) US20090221590A1 (ru)
EP (1) EP1991548B1 (ru)
JP (1) JP5102785B2 (ru)
KR (1) KR101433738B1 (ru)
CN (1) CN101384595B (ru)
AU (1) AU2007217170B2 (ru)
BR (1) BRPI0708114B8 (ru)
CA (1) CA2643668C (ru)
DK (1) DK1991548T3 (ru)
EA (1) EA014101B1 (ru)
ES (1) ES2449569T3 (ru)
GB (1) GB0603522D0 (ru)
IL (1) IL192954A (ru)
NZ (1) NZ570055A (ru)
PL (1) PL1991548T3 (ru)
PT (1) PT1991548E (ru)
UA (1) UA91904C2 (ru)
WO (1) WO2007096588A1 (ru)
ZA (1) ZA200806508B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2284172A1 (en) * 2003-03-14 2011-02-16 MediGene Ltd. Immunomodulating heterocyclic compounds
CA2576256C (en) 2004-08-09 2012-01-03 Avidex Limited Immunomodulating oxopyrrazolocinnolines as cd80 inhibitors
US8519155B2 (en) * 2008-10-31 2013-08-27 C-A-I-R Biosciences Gmbh Choline and tromethamine salt of licofelone
SG183243A1 (en) * 2010-02-10 2012-09-27 Kissei Pharmaceutical Salt of fused heterocyclic derivative and crystal thereof
UA109287C2 (uk) * 2010-11-02 2015-08-10 Солі органічного аміну похідних амінобензойної кислоти і спосіб їх одержання
EP4119128A1 (en) 2021-07-13 2023-01-18 Dr. Falk Pharma Gmbh Pharmaceutical composition for the oral administration of poorly soluble drugs comprising an amorphous solid dispersion

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2670350A (en) * 1952-08-08 1954-02-23 Nepera Chemical Co Inc Method of preparing choline salt of theophylline
US3576637A (en) * 1967-04-20 1971-04-27 Konishiroku Photo Ind Lith-type of emulsion containing pyrozolone
US3778150A (en) * 1971-10-27 1973-12-11 K Aston Printing of photographic colour negatives
JPS523818A (en) * 1975-06-26 1977-01-12 Hoffmann La Roche Salt of penicillanic acid
US4591589A (en) * 1985-01-16 1986-05-27 Roussel Uclaf 2-aryl pyrazolo[4,3-c]cinnolin-3-ones
DE3903993A1 (de) * 1989-02-10 1990-08-16 Basf Ag Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus
IT1290448B1 (it) * 1997-04-01 1998-12-03 Schiena Michele Giuseppe Di Nimesulide sale di colina,metodo di preparazione e composizioni farmaceutiche che lo contengono
EP2284172A1 (en) * 2003-03-14 2011-02-16 MediGene Ltd. Immunomodulating heterocyclic compounds
TW200526638A (en) * 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
GB0325644D0 (en) * 2003-11-04 2003-12-10 Avidex Ltd Immuno ihibitory pyrazolone compounds
GB0411770D0 (en) * 2004-05-26 2004-06-30 Avidex Ltd Immuno inhibitory heterocyclic compouds
CA2576256C (en) * 2004-08-09 2012-01-03 Avidex Limited Immunomodulating oxopyrrazolocinnolines as cd80 inhibitors
WO2006083687A1 (en) * 2005-01-28 2006-08-10 Cardiome Pharma Corp. Crystal salt of xanthine oxidase inhibitors

Also Published As

Publication number Publication date
AU2007217170B2 (en) 2012-02-02
IL192954A (en) 2015-01-29
ZA200806508B (en) 2009-06-24
BRPI0708114B8 (pt) 2021-05-25
EP1991548A1 (en) 2008-11-19
US20180265514A1 (en) 2018-09-20
DK1991548T3 (en) 2014-03-10
IL192954A0 (en) 2009-02-11
WO2007096588A1 (en) 2007-08-30
NZ570055A (en) 2011-08-26
GB0603522D0 (en) 2006-04-05
UA91904C2 (en) 2010-09-10
EA014101B1 (ru) 2010-08-30
CN101384595A (zh) 2009-03-11
PT1991548E (pt) 2014-03-10
US20120004237A1 (en) 2012-01-05
PL1991548T3 (pl) 2014-05-30
ES2449569T3 (es) 2014-03-20
EP1991548B1 (en) 2013-12-11
CA2643668A1 (en) 2007-08-30
KR101433738B1 (ko) 2014-08-25
US20090221590A1 (en) 2009-09-03
HK1125376A1 (en) 2009-08-07
AU2007217170A1 (en) 2007-08-30
CA2643668C (en) 2014-05-13
BRPI0708114A2 (pt) 2011-05-17
JP2009527538A (ja) 2009-07-30
JP5102785B2 (ja) 2012-12-19
BRPI0708114B1 (pt) 2020-02-04
CN101384595B (zh) 2011-02-09
KR20080103523A (ko) 2008-11-27

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment