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EA200800659A1 - Соединения имидазола для лечения неврологических нарушений - Google Patents

Соединения имидазола для лечения неврологических нарушений

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Publication number
EA200800659A1
EA200800659A1 EA200800659A EA200800659A EA200800659A1 EA 200800659 A1 EA200800659 A1 EA 200800659A1 EA 200800659 A EA200800659 A EA 200800659A EA 200800659 A EA200800659 A EA 200800659A EA 200800659 A1 EA200800659 A1 EA 200800659A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imidazol
connections
treatment
compounds
formula
Prior art date
Application number
EA200800659A
Other languages
English (en)
Inventor
Майкл Аарон Бродни
Юхпин Лян Чэнь
Карен Джин Коффман
Эдуард Фокс Клейнман
Брайан Томас О'Нилл
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200800659A1 publication Critical patent/EA200800659A1/ru

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    • A61K31/4164—1,3-Diazoles
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  • Chemical & Material Sciences (AREA)
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Abstract

Настоящее изобретение относится к соединениям формулы (I), где R, R, R, R, R, Rи А имеют значения, как описано в описании. Соединения формулы (I) обладают активностью, ингибирующей продуцирование Аβ-пептида. Данное изобретение также относится к включающим соединения формулы I фармацевтическим композициям и способам лечения заболеваний и нарушений, например нейродегенеративных и/или неврологических нарушений, как, например, болезнь Альцгеймера, у млекопитающего.
EA200800659A 2005-09-22 2006-09-11 Соединения имидазола для лечения неврологических нарушений EA200800659A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71952105P 2005-09-22 2005-09-22
PCT/IB2006/002753 WO2007034326A2 (en) 2005-09-22 2006-09-11 Imidazole compounds for the treatment of neurological disorders

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EA200800659A1 true EA200800659A1 (ru) 2008-08-29

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EA200800659A EA200800659A1 (ru) 2005-09-22 2006-09-11 Соединения имидазола для лечения неврологических нарушений

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US (2) US7781435B2 (ru)
EP (1) EP1940802A2 (ru)
JP (1) JP2009508934A (ru)
KR (1) KR20080040010A (ru)
CN (1) CN101282941A (ru)
AR (1) AR055205A1 (ru)
AU (1) AU2006293619A1 (ru)
BR (1) BRPI0616141A2 (ru)
CA (1) CA2619068A1 (ru)
CR (1) CR9815A (ru)
EA (1) EA200800659A1 (ru)
EC (1) ECSP088280A (ru)
GT (1) GT200600425A (ru)
IL (1) IL189524A0 (ru)
MA (1) MA29793B1 (ru)
NL (1) NL1032552C2 (ru)
NO (1) NO20081845L (ru)
PE (1) PE20070617A1 (ru)
RS (1) RS20080139A (ru)
TN (1) TNSN08138A1 (ru)
TW (1) TW200804300A (ru)
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KR20180030545A (ko) * 2015-06-22 2018-03-23 다이닛본 스미토모 세이야꾸 가부시끼가이샤 바이사이클릭 헤테로사이클릭 아미드 유도체
US10898469B2 (en) 2016-02-26 2021-01-26 Sumitomo Dainippon Pharma Co., Ltd. Imidazolylamide derivative
AU2022339841A1 (en) 2021-09-01 2024-03-28 Springworks Therapeutics, Inc. Synthesis of nirogacestat

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WO2007034326A3 (en) 2007-08-30
US20070066613A1 (en) 2007-03-22
NL1032552C2 (nl) 2007-09-25
KR20080040010A (ko) 2008-05-07
ECSP088280A (es) 2008-04-28
UY29806A1 (es) 2007-04-30
US20100184737A1 (en) 2010-07-22
EP1940802A2 (en) 2008-07-09
MA29793B1 (fr) 2008-09-01
RS20080139A (en) 2009-05-06
BRPI0616141A2 (pt) 2011-06-07
CN101282941A (zh) 2008-10-08
TW200804300A (en) 2008-01-16
AR055205A1 (es) 2007-08-08
US7781435B2 (en) 2010-08-24
IL189524A0 (en) 2008-08-07
NL1032552A1 (nl) 2007-03-23
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NO20081845L (no) 2008-06-19
GT200600425A (es) 2007-05-08
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AU2006293619A1 (en) 2007-03-29
CR9815A (es) 2008-04-16

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