[go: up one dir, main page]

EA200702587A1 - Способ синтеза промежуточных продуктов, предназначенных для получения трициклических бензимидазолов - Google Patents

Способ синтеза промежуточных продуктов, предназначенных для получения трициклических бензимидазолов

Info

Publication number
EA200702587A1
EA200702587A1 EA200702587A EA200702587A EA200702587A1 EA 200702587 A1 EA200702587 A1 EA 200702587A1 EA 200702587 A EA200702587 A EA 200702587A EA 200702587 A EA200702587 A EA 200702587A EA 200702587 A1 EA200702587 A1 EA 200702587A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
intermediate products
products intended
compounds
formula
Prior art date
Application number
EA200702587A
Other languages
English (en)
Inventor
Мария Виттория Киеза
Андреас Пальмер
Вильм Бур
Петер Ян Циммерманн
Кристоф Брем
Вольфганг-Александер Зимон
Штефан Постиус
Вольфганг Кромер
Антонио Дзанотти-Героза
Original Assignee
Никомед Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Никомед Гмбх filed Critical Никомед Гмбх
Publication of EA200702587A1 publication Critical patent/EA200702587A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В заявке описан способ синтеза соединений формулы 1-а и соединений формулы 1-b.Соединения формулы 1-а и соединения формулы 1-b, в которой заместители R1, R2, R3 и Ar обладают значениями, указанными в описании, являются ценными промежуточными продуктами для получения фармацевтически активных соединений.
EA200702587A 2005-06-22 2006-06-20 Способ синтеза промежуточных продуктов, предназначенных для получения трициклических бензимидазолов EA200702587A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05105566 2005-06-22
EP06101699 2006-02-15
PCT/EP2006/063350 WO2006136552A2 (en) 2005-06-22 2006-06-20 Process for the production of intermadiates for the preparation of tricyclic benzimidazoles

Publications (1)

Publication Number Publication Date
EA200702587A1 true EA200702587A1 (ru) 2008-06-30

Family

ID=37067521

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702587A EA200702587A1 (ru) 2005-06-22 2006-06-20 Способ синтеза промежуточных продуктов, предназначенных для получения трициклических бензимидазолов

Country Status (14)

Country Link
US (1) US20080280855A1 (ru)
EP (1) EP1904454A2 (ru)
JP (1) JP2008546736A (ru)
KR (1) KR20080028413A (ru)
AR (1) AR057389A1 (ru)
AU (1) AU2006260960A1 (ru)
BR (1) BRPI0612059A2 (ru)
CA (1) CA2612112A1 (ru)
EA (1) EA200702587A1 (ru)
IL (1) IL187746A0 (ru)
MX (1) MX2007015087A (ru)
NO (1) NO20080262L (ru)
TW (1) TW200726752A (ru)
WO (1) WO2006136552A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2412188C2 (ru) 2006-09-21 2011-02-20 Раквалиа Фарма Инк. Производные бензимидазола в качестве селективных ингибиторов кислотной помпы
WO2008095912A2 (en) * 2007-02-06 2008-08-14 Nycomed Gmbh Enantiopure pharmacologically active tricyclic benzimidazoles
EP2452680B1 (en) 2009-07-09 2019-12-18 RaQualia Pharma Inc. Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility
US8703943B2 (en) * 2010-09-01 2014-04-22 Ambit Biosciences Corporation Optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
TWI768557B (zh) 2015-02-02 2022-06-21 美商佛瑪治療公司 作為ｈｄａｃ抑制劑之3-烷基-4-醯胺基-雙環[4,5,0]羥肟酸
WO2016126726A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4919562B2 (ja) * 2001-09-28 2012-04-18 日本曹達株式会社 ルテニウムヒドリド錯体、アルコール化合物の製造方法およびラセミ体カルボニル化合物の分割方法
US6878838B2 (en) * 2003-03-24 2005-04-12 The University Of North Carolina At Chapel Hill Chiral porous metal phosphonates for heterogeneous asymmetric catalysis
EP1613626A1 (en) * 2003-04-04 2006-01-11 ALTANA Pharma AG Cyclic benzimidazoles
AR046941A1 (es) * 2003-12-19 2006-01-04 Altana Pharma Ag Imidazopiridinas triciclicas y su uso como inhibidores de secrecion de acido gastrico
CA2549860A1 (en) * 2003-12-19 2005-06-30 Altana Pharma Ag Intermediates for the preparation of tricyclic dihydropyrano -imidazo -pyridines derivatives

Also Published As

Publication number Publication date
CA2612112A1 (en) 2006-12-28
AU2006260960A1 (en) 2006-12-28
WO2006136552A3 (en) 2007-03-29
US20080280855A1 (en) 2008-11-13
EP1904454A2 (en) 2008-04-02
KR20080028413A (ko) 2008-03-31
AR057389A1 (es) 2007-12-05
TW200726752A (en) 2007-07-16
IL187746A0 (en) 2008-04-13
BRPI0612059A2 (pt) 2010-10-13
JP2008546736A (ja) 2008-12-25
MX2007015087A (es) 2008-01-24
NO20080262L (no) 2008-01-18
WO2006136552A2 (en) 2006-12-28

Similar Documents

Publication Publication Date Title
EA200800321A1 (ru) Ингибиторы гистондеацетилазы
EA200870116A1 (ru) Бициклические гетероарильные соединения
UY30500A1 (es) Compuestos de azabencimidazolilo
EA200500203A1 (ru) Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат
EA200800760A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
EA201000642A1 (ru) 2'-фтор-2'-дезокситетрагидроуридины в качестве ингибиторов цитидиндеаминазы
EA201200669A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
EA201070186A1 (ru) Способы и соединения, предназначенные для получения ингибиторов котранспортера натрий-глюкозы 2 типа
ES2368594T3 (es) Derivados sustituidos de ciclohexilmetilo.
IL204437A (en) History of aryl cyclic profile and their use
EA200801381A1 (ru) Производные пиримидина
EA200702347A1 (ru) Способ получения глюкопиранозилзамещённых производных бензилбензола и промежуточных продуктов для их получения
ATE483000T1 (de) Naphtalin-amidin-imide
EA200801998A1 (ru) ПИРИДИН[3,4-b]ПИРАЗИНОНЫ
CR9113A (es) Compuestos acetamida como fungicidas
ATE445593T1 (de) Acetylenderivate
EA201000883A1 (ru) Производные индолинона и способ их получения
EA201170722A1 (ru) Лактамы в качестве ингибиторов бета-секретазы
TW200638930A (en) Acetylene derivatives
EA201170154A1 (ru) Производные пиридинопиридинонов, способ их получения и применение в терапии
EA200702587A1 (ru) Способ синтеза промежуточных продуктов, предназначенных для получения трициклических бензимидазолов
EA200801608A1 (ru) Производные бензимидазолонкарбоновой кислоты
EA200900090A1 (ru) Бензиламины, способ их получения и их применение в качестве противовоспалительных средств
GT200500296A (es) Sintesis asimetrica de derivados del dehidrobenzofurano
EA200801366A1 (ru) Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина