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EA200701192A1 - Антагонисты toll-подобного рецептора 3, способы их получения и применение - Google Patents

Антагонисты toll-подобного рецептора 3, способы их получения и применение

Info

Publication number
EA200701192A1
EA200701192A1 EA200701192A EA200701192A EA200701192A1 EA 200701192 A1 EA200701192 A1 EA 200701192A1 EA 200701192 A EA200701192 A EA 200701192A EA 200701192 A EA200701192 A EA 200701192A EA 200701192 A1 EA200701192 A1 EA 200701192A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
toll
receptor
methods
reception
Prior art date
Application number
EA200701192A
Other languages
English (en)
Inventor
Джилл Картон
Марк Каннингхэм
Анук Дас
Карен Даффи
Дэвид М. Найт
Роберта Лэмб
Моухамадоу Л. Мбоу
Гопалан Рагхунатхан
Лани Сан Матео
Роберт Т. Сариски
Николь Стоуэлл
Рэймонд Свит
Шаньжун Чжао
Шичжун Чэнь
Джилл Джайлс-Комар
Кристен Пича
Ведрана Стоянович-Сусулич
Тереза Дж. Голетц
Original Assignee
Сентокор, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сентокор, Инк. filed Critical Сентокор, Инк.
Publication of EA200701192A1 publication Critical patent/EA200701192A1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
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Abstract

Раскрываются антагонисты Toll-подобного рецептора 3 (TLR3), полинуклеотиды, кодирующие антагонисты TLR3 или их фрагменты, а также способы получения и применения вышеуказанных соединений.
EA200701192A 2004-11-30 2005-11-30 Антагонисты toll-подобного рецептора 3, способы их получения и применение EA200701192A1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US63181504P 2004-11-30 2004-11-30
US63639904P 2004-12-15 2004-12-15
US64187705P 2005-01-06 2005-01-06
US71319505P 2005-08-31 2005-08-31
US72761005P 2005-10-18 2005-10-18
PCT/US2005/043373 WO2006060513A2 (en) 2004-11-30 2005-11-30 Toll like receptor 3 antagonists, methods and uses

Publications (1)

Publication Number Publication Date
EA200701192A1 true EA200701192A1 (ru) 2009-12-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701192A EA200701192A1 (ru) 2004-11-30 2005-11-30 Антагонисты toll-подобного рецептора 3, способы их получения и применение

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Country Link
US (1) US8153583B2 (ru)
EP (2) EP2481425A1 (ru)
JP (2) JP5039560B2 (ru)
KR (1) KR101317264B1 (ru)
AR (1) AR051836A1 (ru)
AU (1) AU2005311894A1 (ru)
BR (1) BRPI0518664A2 (ru)
CA (1) CA2589636C (ru)
EA (1) EA200701192A1 (ru)
HK (2) HK1111360A1 (ru)
IL (1) IL183541A (ru)
MX (1) MX2007006442A (ru)
NO (1) NO20073293L (ru)
NZ (1) NZ555475A (ru)
TW (1) TWI487535B (ru)
WO (1) WO2006060513A2 (ru)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
JP5199878B2 (ja) * 2005-10-27 2013-05-15 セントカー・インコーポレーテツド Toll様受容体3モジュレーター、方法および用途
US8066981B2 (en) * 2006-11-14 2011-11-29 The Texas A & M University System Compositions and methods related to toll-like receptor-3
US20080299138A1 (en) * 2007-05-25 2008-12-04 Duffy Karen E Toll-Like Receptor 3 Modulators and Uses Thereof
PL2796466T3 (pl) 2007-12-07 2018-04-30 Zymogenetics, Inc. Humanizowane cząsteczki przeciwciała swoiste dla il-31
CN102083984A (zh) * 2007-12-26 2011-06-01 森托科尔奥索生物科技公司 食蟹猴Toll样受体3
EP2294085A1 (en) * 2008-06-09 2011-03-16 Novartis AG Antibodies against neisserial factor h binding protein
ATE497978T1 (de) * 2008-06-27 2011-02-15 Theranor Sprl Pharmazeutische zusammensetzungen von antikörpern von viruserkrankungen
EP2344175B1 (en) * 2008-10-02 2015-07-22 Janssen Biotech, Inc. Methods for suppressing toll-like receptor activity
JP5751631B2 (ja) * 2008-10-31 2015-07-22 ヤンセン バイオテツク,インコーポレーテツド Toll様受容体3アンタゴニスト
US8460659B2 (en) 2008-10-31 2013-06-11 Janssen Biotech, Inc. Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases
US20100135983A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100137787A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Delivery devices for modulating inflammation
US20100136094A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136096A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136095A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100137246A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
DK2425008T3 (en) 2009-04-29 2015-10-05 Janssen Biotech Inc Toll-like receptor antagonists 3
ES2543095T3 (es) 2009-07-10 2015-08-14 Innate Pharma Agentes de unión a TLR3
WO2011041584A2 (en) 2009-09-30 2011-04-07 President And Fellows Of Harvard College Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
EP2663329A2 (en) 2011-01-12 2013-11-20 Innate Pharma Tlr3 binding agents
WO2013026837A1 (en) * 2011-08-23 2013-02-28 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
CN103748114B (zh) * 2011-08-23 2017-07-21 罗切格利卡特公司 T细胞活化性双特异性抗原结合分子
EA201490623A1 (ru) 2011-09-12 2016-01-29 Янссен Байотек Инк. Антагонисты толл-подобного рецептора 3 для лечения метаболических и сердечно-сосудистых заболеваний
WO2013178736A1 (en) 2012-05-31 2013-12-05 Innate Pharma Tlr3 binding agents
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
CN110437337B (zh) 2013-02-26 2024-07-30 罗切格利卡特公司 双特异性t细胞活化性抗原结合分子
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
JP6681396B2 (ja) 2014-11-17 2020-04-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. Cd3xcd20二特異性抗体を用いて腫瘍を治療する方法
US10556952B2 (en) 2015-03-30 2020-02-11 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to Fc gamma receptors
EP3356410B1 (en) 2015-10-02 2021-10-20 F. Hoffmann-La Roche AG Bispecific anti-ceaxcd3 t cell activating antigen binding molecules
CN108290954B (zh) 2015-12-09 2022-07-26 豪夫迈·罗氏有限公司 Ii型抗cd20抗体用于降低抗药物抗体形成
CN108368179B (zh) 2016-01-08 2022-08-23 豪夫迈·罗氏有限公司 使用pd-1轴结合拮抗剂和抗cea/抗cd3双特异性抗体治疗cea阳性癌症的方法
WO2019246317A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease or condition in a tissue originating from the endoderm
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
MA53495A (fr) 2018-08-31 2021-12-08 Regeneron Pharma Stratégie de dosage permettant d'atténuer le syndrome de libération de cytokines pour des anticorps bispécifiques cd3/c20

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
DK1798288T3 (da) 1997-05-07 2010-01-04 Schering Corp Humane Toll-lignende receptorproteiner, relaterede reagenser og fremgangsmåder
US20030032090A1 (en) * 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
AU3809900A (en) 1999-03-09 2000-09-28 Max-Delbruck-Centrum Fur Molekulare Medizin Therapy and use of compounds in therapy
GB9930616D0 (en) 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
AU2002324937B2 (en) 2001-09-07 2008-11-13 The Trustees Of Boston Univeristy Method and composition for treating immune complex associated disorders
EP1451581A4 (en) 2001-10-05 2006-01-11 Coley Pharm Gmbh AGONISTS AND ANTAGONISTS OF THE SIGNALING OF THE GREAT-SIMILAR RECEPTOR 3
EP1495756A4 (en) 2002-04-08 2009-10-28 Takeda Pharmaceutical THERAPEUTIC AGENT FOR SEVERE SEPTIC STATE PREVENTION
JP2004016021A (ja) * 2002-06-12 2004-01-22 Japan Science & Technology Corp 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット
KR20060016817A (ko) * 2003-06-20 2006-02-22 콜리 파마슈티칼 게엠베하 소분자 톨-유사 수용체 (tlr) 길항제

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