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EA200601588A1 - Стабилизированные перенасыщенные твёрдые растворы липофильных лекарственных средств - Google Patents

Стабилизированные перенасыщенные твёрдые растворы липофильных лекарственных средств

Info

Publication number
EA200601588A1
EA200601588A1 EA200601588A EA200601588A EA200601588A1 EA 200601588 A1 EA200601588 A1 EA 200601588A1 EA 200601588 A EA200601588 A EA 200601588A EA 200601588 A EA200601588 A EA 200601588A EA 200601588 A1 EA200601588 A1 EA 200601588A1
Authority
EA
Eurasian Patent Office
Prior art keywords
lipofile
medicines
stabilized
solid solutions
substituted solid
Prior art date
Application number
EA200601588A
Other languages
English (en)
Other versions
EA012746B1 (ru
Inventor
Адриан Функе
Торстен Вагнер
Ральф Липп
Original Assignee
Шеринг Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34928105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200601588(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Шеринг Акциенгезельшафт filed Critical Шеринг Акциенгезельшафт
Publication of EA200601588A1 publication Critical patent/EA200601588A1/ru
Publication of EA012746B1 publication Critical patent/EA012746B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Данное изобретение касается фармацевтических композиций с улучшенным растворением липофильных действующих веществ в водной среде. Обнаружено, что фармацевтические композиции, содержащие порошок липофильных соединений, таких как гормоны и стероиды (например, дроспиренон и эстрадиола валерат) в молекулярно диспергированной форме вместе с носителем, определенная площадь поверхности которого составляет по крайней мере 250 м/г, таким как диоксид кремния, например, диоксид кремния, продаваемый под названием Aeroperl, имеют улучшенные свойства растворения липофильного действующего вещества.
EA200601588A 2004-03-10 2005-03-10 Порошкообразная композиция и способ ее получения, фармацевтическая лекарственная форма и способ ее получения, применение аморфного кремнезема EA012746B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55133004P 2004-03-10 2004-03-10
EP04075714 2004-03-10
PCT/IB2005/000748 WO2005087199A2 (en) 2004-03-10 2005-03-10 Stabilised supersaturated solid solutions of steroidal drugs

Publications (2)

Publication Number Publication Date
EA200601588A1 true EA200601588A1 (ru) 2007-02-27
EA012746B1 EA012746B1 (ru) 2009-12-30

Family

ID=34928105

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601588A EA012746B1 (ru) 2004-03-10 2005-03-10 Порошкообразная композиция и способ ее получения, фармацевтическая лекарственная форма и способ ее получения, применение аморфного кремнезема

Country Status (32)

Country Link
US (1) US8715735B2 (ru)
EP (2) EP2087883B1 (ru)
JP (1) JP5006185B2 (ru)
KR (1) KR101210695B1 (ru)
CN (1) CN1984644B (ru)
AR (1) AR048500A1 (ru)
AT (1) ATE442131T1 (ru)
AU (1) AU2005221403B8 (ru)
BR (1) BRPI0507342A (ru)
CA (1) CA2558582C (ru)
CR (1) CR8630A (ru)
DE (1) DE602005016551D1 (ru)
DK (1) DK1765290T3 (ru)
EA (1) EA012746B1 (ru)
EC (1) ECSP066902A (ru)
ES (2) ES2332229T3 (ru)
GT (1) GT200500045A (ru)
HR (1) HRP20090614T1 (ru)
IL (1) IL177894A0 (ru)
MY (1) MY142989A (ru)
NO (1) NO20064473L (ru)
NZ (1) NZ549793A (ru)
PA (1) PA8626101A1 (ru)
PE (1) PE20060016A1 (ru)
PL (1) PL1765290T3 (ru)
PT (1) PT1765290E (ru)
RS (1) RS51076B (ru)
SI (1) SI1765290T1 (ru)
SV (1) SV2005002044A (ru)
TW (1) TWI345986B (ru)
UY (1) UY28803A1 (ru)
WO (1) WO2005087199A2 (ru)

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Also Published As

Publication number Publication date
EA012746B1 (ru) 2009-12-30
DK1765290T3 (da) 2009-11-02
TW200600116A (en) 2006-01-01
KR101210695B1 (ko) 2012-12-11
ES2390406T3 (es) 2012-11-12
US20050207990A1 (en) 2005-09-22
PA8626101A1 (es) 2006-07-03
IL177894A0 (en) 2006-12-31
CN1984644A (zh) 2007-06-20
EP1765290A2 (en) 2007-03-28
NO20064473L (no) 2006-10-10
EP1765290B1 (en) 2009-09-09
HRP20090614T1 (hr) 2009-12-31
KR20060132999A (ko) 2006-12-22
JP2007528389A (ja) 2007-10-11
CN1984644B (zh) 2010-12-08
JP5006185B2 (ja) 2012-08-22
WO2005087199A8 (en) 2007-03-29
WO2005087199A2 (en) 2005-09-22
GT200500045A (es) 2005-10-31
AR048500A1 (es) 2006-05-03
CA2558582A1 (en) 2005-09-22
UY28803A1 (es) 2005-10-31
AU2005221403A1 (en) 2005-09-22
US8715735B2 (en) 2014-05-06
EP2087883B1 (en) 2012-07-25
ATE442131T1 (de) 2009-09-15
SI1765290T1 (sl) 2010-01-29
EP2087883A1 (en) 2009-08-12
TWI345986B (en) 2011-08-01
PL1765290T3 (pl) 2010-02-26
PT1765290E (pt) 2009-11-23
ECSP066902A (es) 2006-12-20
SV2005002044A (es) 2005-11-04
AU2005221403B8 (en) 2010-01-07
AU2005221403B2 (en) 2009-12-10
DE602005016551D1 (de) 2009-10-22
PE20060016A1 (es) 2006-02-16
MY142989A (en) 2011-02-14
NZ549793A (en) 2010-06-25
ES2332229T3 (es) 2010-01-29
RS51076B (sr) 2010-10-31
CR8630A (es) 2007-06-06
CA2558582C (en) 2013-07-16
WO2005087199A3 (en) 2009-01-15
HK1103660A1 (en) 2007-12-28
BRPI0507342A (pt) 2007-07-03

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