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EA200601546A1 - 6-ЗАМЕЩЁННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-БЕНЗО[d]АЗЕПИНЫ В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ 5-HT - Google Patents

6-ЗАМЕЩЁННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-БЕНЗО[d]АЗЕПИНЫ В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ 5-HT

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Publication number
EA200601546A1
EA200601546A1 EA200601546A EA200601546A EA200601546A1 EA 200601546 A1 EA200601546 A1 EA 200601546A1 EA 200601546 A EA200601546 A EA 200601546A EA 200601546 A EA200601546 A EA 200601546A EA 200601546 A1 EA200601546 A1 EA 200601546A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzo
tetrahydro
azepin
agonist
receptors
Prior art date
Application number
EA200601546A
Other languages
English (en)
Other versions
EA011011B1 (ru
Inventor
Джон Гордон Аллен
Карин Брайнер
Майкл Филип Коэн
Кристофер Стэнли Галка
Сара Линн Хеллман
Мария Анхелес Мартинес-Грау
Мэттью Роберт Рейнхард
Майкл Джон Родригес
Роджер Райан Ротхаар
Майкл Вэйд Тидуэлл
Франтц Виктор
Эндрю Кервин Уилльямс
Дэи Чжан
Стивен Армен Бойд
Ричард Джерард Конвей
Арундхати С. Део
Вай-Мань Ли
Кристофер Стефен Сидем
Аджай Сингх
Майкл Филип Мазанетц
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34910927&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200601546(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200601546A1 publication Critical patent/EA200601546A1/ru
Publication of EA011011B1 publication Critical patent/EA011011B1/ru

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    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Diabetes (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Данное изобретение обеспечивает 6-замещенные 2,3,4,5-тетрагидро-1Н-бензо[d]азепины формулы I в качестве селективных агонистов рецептора 5-НТдля лечения связанных с 5-HTрасстройств, включая ожирение, обсессивно-компульсивное расстройство, депрессию и тревогугде Rпредставляет собой -C≡C-R, -O-R, -S-Rили -NRR;и другие заместители являются такими, как определено в описании.
EA200601546A 2004-02-25 2005-02-18 6-ЗАМЕЩЁННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-БЕНЗО[d]АЗЕПИНЫ В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ 5-HT EA011011B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54768104P 2004-02-25 2004-02-25
PCT/US2005/005418 WO2005082859A1 (en) 2004-02-25 2005-02-18 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists

Publications (2)

Publication Number Publication Date
EA200601546A1 true EA200601546A1 (ru) 2007-02-27
EA011011B1 EA011011B1 (ru) 2008-12-30

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ID=34910927

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EA200601546A EA011011B1 (ru) 2004-02-25 2005-02-18 6-ЗАМЕЩЁННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-БЕНЗО[d]АЗЕПИНЫ В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ 5-HT

Country Status (29)

Country Link
US (2) US8022062B2 (ru)
EP (2) EP2479168B1 (ru)
JP (1) JP4796047B2 (ru)
KR (1) KR100848411B1 (ru)
CN (3) CN102311387A (ru)
AR (1) AR048242A1 (ru)
AU (1) AU2005217602B2 (ru)
BR (1) BRPI0507986A (ru)
CA (1) CA2556390C (ru)
CL (1) CL2010001292A1 (ru)
CR (1) CR8566A (ru)
DK (1) DK1720836T3 (ru)
DO (1) DOP2005000024A (ru)
EA (1) EA011011B1 (ru)
EC (1) ECSP066788A (ru)
ES (2) ES2468741T3 (ru)
IL (1) IL177267A (ru)
MA (1) MA28486B1 (ru)
MY (1) MY141992A (ru)
NO (1) NO20064277L (ru)
NZ (2) NZ549009A (ru)
PE (1) PE20060010A1 (ru)
PL (1) PL1720836T3 (ru)
PT (1) PT1720836E (ru)
SI (1) SI1720836T1 (ru)
SV (1) SV2005002025A (ru)
UA (1) UA85699C2 (ru)
WO (1) WO2005082859A1 (ru)
ZA (1) ZA200606580B (ru)

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