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EA200501136A1 - Триазольные соединения, полезные в терапии - Google Patents

Триазольные соединения, полезные в терапии

Info

Publication number
EA200501136A1
EA200501136A1 EA200501136A EA200501136A EA200501136A1 EA 200501136 A1 EA200501136 A1 EA 200501136A1 EA 200501136 A EA200501136 A EA 200501136A EA 200501136 A EA200501136 A EA 200501136A EA 200501136 A1 EA200501136 A1 EA 200501136A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
substituted
ring
independently represent
halogen
Prior art date
Application number
EA200501136A
Other languages
English (en)
Other versions
EA009460B1 (ru
Inventor
Джастин Стивен Брайанс
Патрик Стивен Джонсон
Томас Рикманс
Алан Стоби
Рейчел Джейн Рассел
Кристофер Питер Уайман
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0303852.8A external-priority patent/GB0303852D0/en
Priority claimed from GBGB0317227.7A external-priority patent/GB0317227D0/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200501136A1 publication Critical patent/EA200501136A1/ru
Publication of EA009460B1 publication Critical patent/EA009460B1/ru

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Abstract

Соединение формулы (I) или его фармацевтически приемлемое производное, где V представляет собой -(CH)(O)-, -CO- или -CH(Салкил)-; W представляет собой -О-, -S(O)или -N(R)-; Rпредставляет собой Н, Салкил, (CH)COR, CO(CH)NRR, SOR, (CH)OR, (CH)NRRили (CH)het; hetпредставляет собой насыщенный или ненасыщенный гетероцикл из 3-8 атомов, содержащих один или более чем один гетероатом, выбранный из О, N или S, возможно замещенный Cалкилом; Х и Y независимо представляют собой Н, Cалкил, галоген, ОН, CF, OCF, OR; Z представляет собой -(CH)(O), -СО- или -СН(Салкил)-; кольцо А представляет собой 4-7-членный насыщенный N-содержащий гетероцикл, возможно замещенный ОН, и где возможно по меньшей мере один кольцевой N замещен О; кольцо В представляет собой фенил или 4-7-членный ненасыщенный N-содержащий гетероцикл, возможно замещенный ОН, галогеном, CN, CONH, CF, OCF, и где возможно по меньшей мере один кольцевой N замещен О; Rи Rнезависимо представляют собой Н, Cалкил [возможно замещенный ОН, галогеном, N(Салкил)или Cалкилокси], Cалкилокси, Н(Салкил)или [Сциклоалкил]; или Rи Rвместе с атомом азота, к которому они присоединены, независимо представляют собой гетероцикл из 3-8 атомов, возможно замещенный Cалкилом; Rпредставляет собой неразветвленный или разветвленный Cалкил, а и с независимо представляют собой 0, 1 или 2; b, е и g независимо представляют собой 0 или 1; d и f независимо представляют собой 1 или 2; полезны в лечении дисменореи.
EA200501136A 2003-02-19 2004-02-09 Триазольные соединения, полезные в терапии EA009460B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0303852.8A GB0303852D0 (en) 2003-02-19 2003-02-19 Triazole compounds useful in therapy
GBGB0317227.7A GB0317227D0 (en) 2003-07-23 2003-07-23 Treatment of male sexual dysfunction
PCT/IB2004/000432 WO2004074291A1 (en) 2003-02-19 2004-02-09 Triazole compounds useful in therapy

Publications (2)

Publication Number Publication Date
EA200501136A1 true EA200501136A1 (ru) 2006-06-30
EA009460B1 EA009460B1 (ru) 2007-12-28

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EA200501136A EA009460B1 (ru) 2003-02-19 2004-02-09 Триазольные соединения, полезные в терапии

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JP (2) JP4033886B2 (ru)
KR (1) KR100750028B1 (ru)
AP (1) AP2005003376A0 (ru)
AT (1) ATE349449T1 (ru)
AU (1) AU2004213242B2 (ru)
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EC (1) ECSP055973A (ru)
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MA (1) MA27712A1 (ru)
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OA (1) OA13029A (ru)
PL (1) PL378747A1 (ru)
PT (1) PT1597260E (ru)
RS (1) RS20050638A (ru)
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CA2779088A1 (en) * 2009-11-16 2011-05-19 Mellitech [1,5]-diazocin derivatives
US8420633B2 (en) * 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) * 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) * 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
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