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EA200300727A1 - Производные 2h-1-бензопирана, способы их получения и их фармацевтические композиции - Google Patents

Производные 2h-1-бензопирана, способы их получения и их фармацевтические композиции

Info

Publication number
EA200300727A1
EA200300727A1 EA200300727A EA200300727A EA200300727A1 EA 200300727 A1 EA200300727 A1 EA 200300727A1 EA 200300727 A EA200300727 A EA 200300727A EA 200300727 A EA200300727 A EA 200300727A EA 200300727 A1 EA200300727 A1 EA 200300727A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
methods
pharmaceutical compositions
benzopirane
production
Prior art date
Application number
EA200300727A
Other languages
English (en)
Other versions
EA006158B1 (ru
Inventor
Маурицио Дельканале
Габриеле Амари
Элизабетта Армани
Маурицио Чивелли
Элизабетта Гальбиати
Original Assignee
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01101521A external-priority patent/EP1229036B1/en
Priority claimed from EP01118682A external-priority patent/EP1281710A1/en
Application filed by КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. filed Critical КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Publication of EA200300727A1 publication Critical patent/EA200300727A1/ru
Publication of EA006158B1 publication Critical patent/EA006158B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Производные 2H-1-бензопирана, способы их получения и их применение для приготовления фармацевтических композиций для предупреждения и лечения постменопаузальных патологий.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300727A 2001-01-24 2002-01-21 Производные 2h-1-бензопирана и содержащая их фармацевтическая композиция EA006158B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01101521A EP1229036B1 (en) 2001-01-24 2001-01-24 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
EP01118682A EP1281710A1 (en) 2001-08-03 2001-08-03 2H-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
PCT/EP2002/000567 WO2002059113A1 (en) 2001-01-24 2002-01-21 2h-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
EA200300727A1 true EA200300727A1 (ru) 2004-02-26
EA006158B1 EA006158B1 (ru) 2005-10-27

Family

ID=26076450

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300727A EA006158B1 (ru) 2001-01-24 2002-01-21 Производные 2h-1-бензопирана и содержащая их фармацевтическая композиция

Country Status (26)

Country Link
US (1) US6951883B2 (ru)
EP (1) EP1355906B1 (ru)
JP (1) JP4332349B2 (ru)
CN (1) CN1261431C (ru)
AT (1) ATE286894T1 (ru)
AU (1) AU2002237282B2 (ru)
BR (1) BR0207066A (ru)
CA (1) CA2435775A1 (ru)
CZ (1) CZ20032014A3 (ru)
DE (1) DE60202590T2 (ru)
DK (1) DK1355906T3 (ru)
DZ (1) DZ3459A1 (ru)
EA (1) EA006158B1 (ru)
ES (1) ES2236485T3 (ru)
HU (1) HUP0401018A3 (ru)
IL (2) IL157065A0 (ru)
MA (1) MA26982A1 (ru)
MX (1) MXPA03006505A (ru)
NO (1) NO327808B1 (ru)
NZ (1) NZ527144A (ru)
PL (1) PL365062A1 (ru)
PT (1) PT1355906E (ru)
SI (1) SI1355906T1 (ru)
SK (1) SK287086B6 (ru)
TN (1) TNSN03043A1 (ru)
WO (1) WO2002059113A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1809618B1 (en) * 2004-09-21 2013-07-17 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
AU2005201855B2 (en) * 2004-09-21 2012-03-29 Marshall Edwards, Inc. Chroman derived compounds and formulations thereof for use in therapy
JP4976649B2 (ja) * 2004-09-21 2012-07-18 マーシャル エドワーズ，インク． 化合物
ES2377073T3 (es) * 2004-09-21 2012-03-22 Marshall Edwards, Inc. Derivados de cromano sustituidos, medicamentos y utilización en terapia
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
EP1794141B1 (en) * 2004-09-21 2011-11-09 Marshall Edwards, Inc. Substituted chroman derivatives, medicaments and use in therapy
CN101444499B (zh) * 2007-11-26 2012-12-05 湘北威尔曼制药股份有限公司 一种化合物及其组合物的新用途
WO2012061413A2 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compositions and methods for the treatment of cancer
CN105324115B (zh) 2013-06-19 2019-01-04 赛拉根医药股份有限公司 雌激素受体调节剂及其用途
US10980774B2 (en) 2015-02-02 2021-04-20 Mei Pharma, Inc. Combination therapies
WO2018091153A1 (en) * 2016-11-17 2018-05-24 Sanofi Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
EP3681495A4 (en) * 2017-09-15 2021-06-02 Nyrada Pty Limited TREATMENT OF EXCITOTOXICITY
CN112225716A (zh) * 2020-10-30 2021-01-15 陕西嘉禾生物科技股份有限公司 一种鹰嘴豆牙素a的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3374245A (en) * 1964-04-01 1968-03-19 Ciba Geigy Corp Unsaturated oxacycles
DE1518002C3 (de) * 1965-01-02 1975-01-23 Merck Patent Gmbh, 6100 Darmstadt Isoflavane und Isoflavene und Verfahren zu Ihrer Herstellung sowie diese enthaltende Arzneimittel
US5280040A (en) 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
JP2001502706A (ja) * 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ エストロゲン関連病あるいは症候群の予防または治療に有用な新規トランス―３，４クロマン誘導体
US5985306A (en) 1996-10-28 1999-11-16 Novo Nordisk A/S (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes
KR19980064120A (ko) * 1996-12-13 1998-10-07 김정규 신규한 벤조피란 유도체
KR20000001793A (ko) 1998-06-13 2000-01-15 이경하 신규한 벤조피란 또는 티오벤조피란 유도체
EP1140889B1 (en) * 1998-12-30 2003-08-27 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors

Also Published As

Publication number Publication date
SK287086B6 (sk) 2009-11-05
HUP0401018A2 (hu) 2004-09-28
ES2236485T3 (es) 2005-07-16
IL157065A (en) 2010-05-17
EP1355906B1 (en) 2005-01-12
NO20033318L (no) 2003-09-24
HK1060558A1 (en) 2004-08-13
BR0207066A (pt) 2004-03-30
WO2002059113A1 (en) 2002-08-01
MXPA03006505A (es) 2004-04-21
EA006158B1 (ru) 2005-10-27
PT1355906E (pt) 2005-05-31
HUP0401018A3 (en) 2007-05-29
PL365062A1 (en) 2004-12-27
US6951883B2 (en) 2005-10-04
AU2002237282B2 (en) 2007-02-15
SK9392003A3 (en) 2003-12-02
CZ20032014A3 (cs) 2003-12-17
ATE286894T1 (de) 2005-01-15
IL157065A0 (en) 2004-02-08
CN1487934A (zh) 2004-04-07
NO20033318D0 (no) 2003-07-23
DE60202590D1 (de) 2005-02-17
DE60202590T2 (de) 2005-12-29
NZ527144A (en) 2005-03-24
CA2435775A1 (en) 2002-08-01
US20040106595A1 (en) 2004-06-03
MA26982A1 (fr) 2004-12-20
TNSN03043A1 (en) 2005-12-23
SI1355906T1 (en) 2005-06-30
NO327808B1 (no) 2009-09-28
DZ3459A1 (fr) 2002-08-01
DK1355906T3 (da) 2005-05-30
JP2004517151A (ja) 2004-06-10
JP4332349B2 (ja) 2009-09-16
CN1261431C (zh) 2006-06-28
EP1355906A1 (en) 2003-10-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU