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EA200300270A1 - ИММУНОГЕННЫЕ ХИМЕРНЫЕ ЧАСТИЦЫ НВс, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ СТАБИЛЬНОСТЬЮ - Google Patents

ИММУНОГЕННЫЕ ХИМЕРНЫЕ ЧАСТИЦЫ НВс, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ СТАБИЛЬНОСТЬЮ

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Publication number
EA200300270A1
EA200300270A1 EA200300270A EA200300270A EA200300270A1 EA 200300270 A1 EA200300270 A1 EA 200300270A1 EA 200300270 A EA200300270 A EA 200300270A EA 200300270 A EA200300270 A EA 200300270A EA 200300270 A1 EA200300270 A1 EA 200300270A1
Authority
EA
Eurasian Patent Office
Prior art keywords
immunogenous
nvs
owned
increased stability
particles
Prior art date
Application number
EA200300270A
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English (en)
Other versions
EA006207B1 (ru
Inventor
Эшли Дж. Биркетт
Original Assignee
Эповиа, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эповиа, Инк. filed Critical Эповиа, Инк.
Publication of EA200300270A1 publication Critical patent/EA200300270A1/ru
Publication of EA006207B1 publication Critical patent/EA006207B1/ru

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Abstract

Описан усеченный по карбокси-концу химерный нуклеокапсидный белок HBc вируса гепатита B, который сконструирован в целях повышения стабильности самособирающихся частиц и который представляет иммуногенный эпитоп. Такое представление иммуногенного эпитопа присходит в иммуногенной петле HBc, в то время как усиление стабильности самособирающихся частиц достигается благодаря присутствию по крайней мере одного гетерологичного цистеинового остатка возле карбокси-конца указанной химерной молекулы. Также описаны способы получения и использования указанных химер.Отчет о международном поиске был опубликован 2003.06.05.
EA200300270A 2000-08-16 2001-08-16 ИММУНОГЕННЫЕ ХИМЕРНЫЕ ЧАСТИЦЫ НВс, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ СТАБИЛЬНОСТЬЮ EA006207B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22584300P 2000-08-16 2000-08-16
US22686700P 2000-08-22 2000-08-22
US09/930,915 US20030138769A1 (en) 2000-08-16 2001-08-15 Immunogenic HBc chimer particles having enhanced stability
PCT/US2001/041759 WO2002014478A2 (en) 2000-08-16 2001-08-16 IMMUNOGENIC HBc CHIMER PARTICLES HAVING ENHANCED STABILITY

Publications (2)

Publication Number Publication Date
EA200300270A1 true EA200300270A1 (ru) 2004-04-29
EA006207B1 EA006207B1 (ru) 2005-10-27

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Country Link
US (3) US20030138769A1 (ru)
EP (1) EP1333857A4 (ru)
JP (2) JP2005517380A (ru)
KR (1) KR20030084887A (ru)
AP (1) AP2003002752A0 (ru)
AU (2) AU2001285452B2 (ru)
BR (1) BR0113307A (ru)
CA (1) CA2420037A1 (ru)
EA (1) EA006207B1 (ru)
MX (1) MXPA03001338A (ru)
OA (1) OA12366A (ru)
WO (1) WO2002014478A2 (ru)

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BR0113307A (pt) 2005-06-28
EP1333857A4 (en) 2006-02-22
US20040156864A1 (en) 2004-08-12
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EA006207B1 (ru) 2005-10-27
AU8545201A (en) 2002-02-25
WO2002014478A3 (en) 2003-06-05
EP1333857A2 (en) 2003-08-13
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WO2002014478A2 (en) 2002-02-21
US20040152876A1 (en) 2004-08-05
MXPA03001338A (es) 2004-01-26
AP2003002752A0 (en) 2003-06-30
US20030138769A1 (en) 2003-07-24
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AU2001285452B2 (en) 2006-11-02
KR20030084887A (ko) 2003-11-01

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