EA200100395A1 - PHARMACEUTICAL COMPOSITION CONTAINING DNA FRAGMENTS ENCODING ANTIGENIC PROTEIN COATING ANTI-ANTITROTHAL EFFECT - Google Patents
PHARMACEUTICAL COMPOSITION CONTAINING DNA FRAGMENTS ENCODING ANTIGENIC PROTEIN COATING ANTI-ANTITROTHAL EFFECTInfo
- Publication number
- EA200100395A1 EA200100395A1 EA200100395A EA200100395A EA200100395A1 EA 200100395 A1 EA200100395 A1 EA 200100395A1 EA 200100395 A EA200100395 A EA 200100395A EA 200100395 A EA200100395 A EA 200100395A EA 200100395 A1 EA200100395 A1 EA 200100395A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- antitrothal
- effect
- composition containing
- dna fragments
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 230000000890 antigenic effect Effects 0.000 title 1
- 239000011248 coating agent Substances 0.000 title 1
- 238000000576 coating method Methods 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000053602 DNA Human genes 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Согласно данному изобретению предложена фармацевтическая композиция, содержащая одну или более чем одну молекулу ДНК, кодирующую фрагменты белка, сверхпродукция которого происходит в опухолевых клетках, для индуцирования противоопухолевого Ag-специфического иммунного ответа (Ag-антиген) в сочетании с подходящими эксципиентами и адъювантами.Отчет о международном поиске был опубликован 2000.08.10.According to the present invention, there is provided a pharmaceutical composition comprising one or more than one DNA molecule encoding protein fragments, which are overproduced in tumor cells, for inducing an antitumor Ag-specific immune response (Ag-antigen) in combination with suitable excipients and adjuvants. Report The international search was published on 2000.08.10.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI002330A IT1303683B1 (en) | 1998-10-30 | 1998-10-30 | PHARMACEUTICAL COMPOSITION WITH ANTI-TUMORAL ACTION CONTAINING DNACODIFIER FOR FRAGMENTS OF AN ANTIGENIC PROTEIN. |
| PCT/EP1999/007874 WO2000025827A2 (en) | 1998-10-30 | 1999-10-18 | Dna molecules encoding muc-1 and use thereof in tumor vaccination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200100395A1 true EA200100395A1 (en) | 2001-10-22 |
Family
ID=11380969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100395A EA200100395A1 (en) | 1998-10-30 | 1999-10-18 | PHARMACEUTICAL COMPOSITION CONTAINING DNA FRAGMENTS ENCODING ANTIGENIC PROTEIN COATING ANTI-ANTITROTHAL EFFECT |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1124956A2 (en) |
| JP (1) | JP2002528519A (en) |
| CN (1) | CN1324406A (en) |
| AR (1) | AR020927A1 (en) |
| AU (1) | AU1152200A (en) |
| BG (1) | BG105458A (en) |
| BR (1) | BR9914892A (en) |
| CA (1) | CA2348745A1 (en) |
| CO (1) | CO5231134A1 (en) |
| CZ (1) | CZ20011521A3 (en) |
| EA (1) | EA200100395A1 (en) |
| HU (1) | HUP0103784A2 (en) |
| IT (1) | IT1303683B1 (en) |
| MX (1) | MXPA01004186A (en) |
| PE (1) | PE20001287A1 (en) |
| PL (1) | PL348156A1 (en) |
| SK (1) | SK5712001A3 (en) |
| TR (1) | TR200101141T2 (en) |
| WO (1) | WO2000025827A2 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548643B1 (en) | 1994-11-16 | 2003-04-15 | Austin Research Institute | Antigen carbohydrate compounds and their use in immunotherapy |
| CA2399026A1 (en) * | 2000-02-01 | 2001-08-09 | The Austin Research Institute | Mucin-1 derived antigens and their use in immunotherapy |
| KR20030068536A (en) * | 2000-09-11 | 2003-08-21 | 다나-파버 캔서 인스티튜트 | Muc1 extracellular domain and cancer treatment compositions and methods derived therefrom |
| JP4276432B2 (en) | 2000-12-22 | 2009-06-10 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | Method for regulating cell growth by MUC1 |
| DE602004027902D1 (en) * | 2003-03-24 | 2010-08-12 | Scripps Research Inst | DNA Vaccinia Against Tumor Growth And Method Of Use Therefor |
| US7696306B2 (en) * | 2003-07-11 | 2010-04-13 | Board of Agents of the University of Nebraska | Compositions and methods for preventing or treating cancer |
| US8129506B2 (en) | 2003-10-24 | 2012-03-06 | Genzyme Corporation | Modulation of the interaction of MUC1 with MUC1 ligands |
| US7871784B2 (en) | 2007-02-02 | 2011-01-18 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins |
| WO2008097840A2 (en) | 2007-02-02 | 2008-08-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of muc1 by hsf1 and stat3 |
| CN106279435B (en) * | 2016-08-16 | 2019-06-07 | 新乡医学院 | Target anti-tumor vaccine, encoding gene, expression vector, expression engineering bacteria and the application of VEGF and mucin1 |
| CN114230656B (en) * | 2021-03-24 | 2025-02-25 | 深圳市新靶向生物科技有限公司 | An antigen peptide combination related to esophageal cancer driver gene mutation and its application |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1262545B (en) * | 1993-10-25 | 1996-07-02 | Menarini Ricerche Sud S P A A | EXPRESSION SYSTEM FOR EUKARYOTIC CELL LINES |
| EP1012276A2 (en) * | 1997-02-24 | 2000-06-28 | Therion Biologics Corporation | Recombinant pox virus for immunization against muc1 tumor-associated antigen |
-
1998
- 1998-10-30 IT IT1998MI002330A patent/IT1303683B1/en active
-
1999
- 1999-10-18 BR BR9914892-7A patent/BR9914892A/en not_active IP Right Cessation
- 1999-10-18 EA EA200100395A patent/EA200100395A1/en unknown
- 1999-10-18 HU HU0103784A patent/HUP0103784A2/en unknown
- 1999-10-18 EP EP99971329A patent/EP1124956A2/en not_active Withdrawn
- 1999-10-18 CN CN99812745A patent/CN1324406A/en active Pending
- 1999-10-18 AU AU11522/00A patent/AU1152200A/en not_active Abandoned
- 1999-10-18 WO PCT/EP1999/007874 patent/WO2000025827A2/en not_active Application Discontinuation
- 1999-10-18 JP JP2000579265A patent/JP2002528519A/en active Pending
- 1999-10-18 SK SK571-2001A patent/SK5712001A3/en unknown
- 1999-10-18 MX MXPA01004186A patent/MXPA01004186A/en unknown
- 1999-10-18 TR TR2001/01141T patent/TR200101141T2/en unknown
- 1999-10-18 CA CA002348745A patent/CA2348745A1/en not_active Abandoned
- 1999-10-18 PL PL99348156A patent/PL348156A1/en unknown
- 1999-10-18 CZ CZ20011521A patent/CZ20011521A3/en unknown
- 1999-10-21 AR ARP990105316A patent/AR020927A1/en unknown
- 1999-10-22 PE PE1999001068A patent/PE20001287A1/en not_active Application Discontinuation
- 1999-10-29 CO CO99068636A patent/CO5231134A1/en not_active Application Discontinuation
-
2001
- 2001-04-20 BG BG105458A patent/BG105458A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1303683B1 (en) | 2001-02-23 |
| ITMI982330A0 (en) | 1998-10-30 |
| MXPA01004186A (en) | 2002-06-04 |
| EP1124956A2 (en) | 2001-08-22 |
| PE20001287A1 (en) | 2000-12-07 |
| CO5231134A1 (en) | 2002-12-27 |
| JP2002528519A (en) | 2002-09-03 |
| AR020927A1 (en) | 2002-06-05 |
| AU1152200A (en) | 2000-05-22 |
| CZ20011521A3 (en) | 2001-10-17 |
| BR9914892A (en) | 2001-07-17 |
| PL348156A1 (en) | 2002-05-06 |
| WO2000025827A3 (en) | 2000-08-10 |
| HUP0103784A2 (en) | 2002-02-28 |
| ITMI982330A1 (en) | 2000-04-30 |
| SK5712001A3 (en) | 2002-04-04 |
| CA2348745A1 (en) | 2000-05-11 |
| CN1324406A (en) | 2001-11-28 |
| BG105458A (en) | 2002-06-28 |
| TR200101141T2 (en) | 2001-09-21 |
| WO2000025827A2 (en) | 2000-05-11 |
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