[go: up one dir, main page]

EA199700242A1 - Индазолкарбоксамиды, способ их получения, фармкомпозиция и способ ингибирования 5-нтрецептора - Google Patents

Индазолкарбоксамиды, способ их получения, фармкомпозиция и способ ингибирования 5-нтрецептора

Info

Publication number
EA199700242A1
EA199700242A1 EA199700242A EA199700242A EA199700242A1 EA 199700242 A1 EA199700242 A1 EA 199700242A1 EA 199700242 A EA199700242 A EA 199700242A EA 199700242 A EA199700242 A EA 199700242A EA 199700242 A1 EA199700242 A1 EA 199700242A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmocomposition
ntreceptor
indasolkarboxamida
inhibiting
recovery
Prior art date
Application number
EA199700242A
Other languages
English (en)
Other versions
EA000699B1 (ru
Inventor
Джон Т. Кэтлоу
Марлен Л. Кохен
Майкл Дж. Мартинелли
Джон М. Скаус
Стивен П. Свансон
Деннис С. Томпсон
Томас М. Уилсон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/485,956 external-priority patent/US5654320A/en
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199700242A1 publication Critical patent/EA199700242A1/ru
Publication of EA000699B1 publication Critical patent/EA000699B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Paper (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Luminescent Compositions (AREA)

Abstract

Предложены индазолкарбоксамиды для применения в качестве антагонистов и частичных агонистов серотонинового рецептора 5-HT, а также терапевтические способы лечения заболеваний, вызванных нарушением или подверженных влиянию нарушения функции рецептора 5-HT, с использованием таких соединений.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700242A 1995-03-16 1996-03-14 Индазолкарбоксамиды, способ их получения, фармкомпозиция и способ ингибирования 5-нт4 рецептора EA000699B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40511995A 1995-03-16 1995-03-16
US08/485,956 US5654320A (en) 1995-03-16 1995-06-07 Indazolecarboxamides
PCT/US1996/003551 WO1996033713A1 (en) 1995-03-16 1996-03-14 Indazolecarboxamides

Publications (2)

Publication Number Publication Date
EA199700242A1 true EA199700242A1 (ru) 1998-04-30
EA000699B1 EA000699B1 (ru) 2000-02-28

Family

ID=27018928

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700242A EA000699B1 (ru) 1995-03-16 1996-03-14 Индазолкарбоксамиды, способ их получения, фармкомпозиция и способ ингибирования 5-нт4 рецептора

Country Status (23)

Country Link
US (2) US5817676A (ru)
EP (1) EP0732333B1 (ru)
JP (1) JPH11502230A (ru)
CN (1) CN1112923C (ru)
AT (1) ATE203748T1 (ru)
AU (1) AU700842B2 (ru)
BR (1) BR9608223A (ru)
CA (1) CA2215359A1 (ru)
DE (1) DE69614164T2 (ru)
DK (1) DK0732333T3 (ru)
EA (1) EA000699B1 (ru)
ES (1) ES2159345T3 (ru)
GR (1) GR3037029T3 (ru)
HU (1) HU223973B1 (ru)
IL (1) IL117438A (ru)
NO (1) NO312833B1 (ru)
NZ (1) NZ315971A (ru)
PL (1) PL183867B1 (ru)
PT (1) PT732333E (ru)
RO (1) RO119617B1 (ru)
SK (1) SK283924B6 (ru)
TR (1) TR199700956T1 (ru)
WO (1) WO1996033713A1 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US5914405A (en) * 1997-10-07 1999-06-22 Eli Lilly And Company Process for preparing 3-substituted indazoles
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
ES2257869T3 (es) * 1998-08-21 2006-08-01 Novartis Ag Nueva formulacion oral para agonistas o antagonistas de 5-ht4.
BRPI9913542B8 (pt) 1998-09-10 2021-05-25 Hoffmann La Roche derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos
AU2001270304A1 (en) 2000-07-07 2002-01-21 The Administrators Of The Tulane Educational Fund Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor
US20050032866A1 (en) * 2000-08-07 2005-02-10 Bonhomme Mireille Marguerite Jeanne The use of 5ht4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
EP1321142A1 (en) * 2001-12-21 2003-06-25 Novartis AG Solid pharmaceutical composition for oral administration of Tegaserod
AU2003208711A1 (en) * 2002-02-12 2003-09-04 Akzo Nobel N.V. 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders
ITMI20030287A1 (it) * 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20031467A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco attivo nel dolore neuropatico
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
SE0401969D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Piperidine derivatives
WO2007010390A1 (en) * 2005-07-22 2007-01-25 Pfizer Japan Inc. Indazolecarboxamide derivatives as 5ht4 receptor agonists
WO2009106980A2 (en) * 2008-02-29 2009-09-03 Pfizer Inc. Indazole derivatives
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145215A (en) * 1961-12-19 1964-08-18 Sterling Drug Inc Indazole derivatives
JP2795460B2 (ja) * 1988-06-20 1998-09-10 協和醗酵工業株式会社 ピラゾロアクリドン誘導体
NZ230068A (en) * 1988-07-29 1991-07-26 Dainippon Pharmaceutical Co Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions
EP0410509A1 (en) * 1989-07-25 1991-01-30 Duphar International Research B.V New substituted 1H-indazole-3-carboxamides
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
EP0600955A1 (en) * 1991-08-20 1994-06-15 Smithkline Beecham Plc 5-ht4 receptor antagonists
US5552398A (en) * 1991-09-12 1996-09-03 Smithkline Beecham P.L.C. Azabicyclic compounds as 5-HT4 receptor antagonists
JPH07507290A (ja) * 1992-05-23 1995-08-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 不安症の治療のための医薬
WO1994000113A2 (en) * 1992-06-27 1994-01-06 Smithkline Beecham Plc Medicaments containing 5-ht4 receptor antagonists
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
TW251287B (ru) * 1993-04-30 1995-07-11 Nissei Co Ltd
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals

Also Published As

Publication number Publication date
IL117438A0 (en) 1996-07-23
PT732333E (pt) 2001-11-30
CN1183041A (zh) 1998-05-27
HUP9801386A3 (en) 2000-03-28
JPH11502230A (ja) 1999-02-23
DK0732333T3 (da) 2001-10-08
GR3037029T3 (en) 2002-01-31
RO119617B1 (ro) 2005-01-28
NO312833B1 (no) 2002-07-08
ATE203748T1 (de) 2001-08-15
PL322362A1 (en) 1998-01-19
WO1996033713A1 (en) 1996-10-31
DE69614164T2 (de) 2002-04-25
MX9706967A (es) 1997-11-29
EA000699B1 (ru) 2000-02-28
HUP9801386A2 (hu) 1999-06-28
HU223973B1 (hu) 2005-03-29
US5817676A (en) 1998-10-06
TR199700956T1 (xx) 1998-02-21
SK124297A3 (en) 1998-02-04
BR9608223A (pt) 1998-12-29
EP0732333B1 (en) 2001-08-01
AU6894896A (en) 1996-11-18
CA2215359A1 (en) 1996-10-31
SK283924B6 (sk) 2004-05-04
NO974221L (no) 1997-10-27
PL183867B1 (pl) 2002-07-31
EP0732333A1 (en) 1996-09-18
AU700842B2 (en) 1999-01-14
DE69614164D1 (de) 2001-09-06
US5798367A (en) 1998-08-25
ES2159345T3 (es) 2001-10-01
CN1112923C (zh) 2003-07-02
NZ315971A (en) 1999-01-28
NO974221D0 (no) 1997-09-12
IL117438A (en) 2001-12-23

Similar Documents

Publication Publication Date Title
BG101806A (bg) Индолови производни като антагонисти на 5-нт рецептори
EA199700242A1 (ru) Индазолкарбоксамиды, способ их получения, фармкомпозиция и способ ингибирования 5-нтрецептора
DK0640592T3 (da) N-acylerede tricycliske azaheteroringe anvendelige som vasopressin-antagonister
EA199700117A1 (ru) Трициклические бензазепиновые антагонисты вазопрессина, способ их получения, фармацевтическая композиция и способ лечения млекопитающих с использованием трициклических бензазепинов
RU93058531A (ru) Фторалкоксибензиламинные производные азотсодержащих гетероциклов, фармацевтическая композиция, способ лечения
ATE279181T1 (de) Verwendung von 5ht-6 antagonisten zur behandlung adhd
EA199800733A1 (ru) Антагонисты рецептора il-8
DE60236206D1 (de) Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
EP1173484A4 (en) TREATMENT OF FIBROSIS BY ANTAGONISM BETWEEN IL-13 AND IL-13 RECEPTOR CHAINS
MXPA00010060A (es) Receptores de serotonina humana constitutivamente activados, no endogenos y moduladores de molecula pequenos de los mismos.
EA200200647A1 (ru) АГОНИСТЫ β2-АДРЕНЕРГИЧЕСКОГО РЕЦЕПТОРА
AR002459A1 (es) Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
DK0804236T3 (da) Anvendelse af anti-TNF-antistoffer som lægemidler til behandling af sygdomme, som involverer forhøjede interleukin-6-serumniveauer
DE69735367D1 (de) THERAPEUTISCHE MULTISPEZIFISCHE VERBINDUNGEN, DIE ANTIKÖRPER GEGEN DEN FCalpha-REZEPTOR ENTHALTEN
TR200000755T2 (tr) Karşıt olma-karşı gelme bozukluğunun tedavisi.
UA66865C2 (ru) Инденопирролокарбазолы, фармацевтическая композиция, способ ингибирования киназной активности и способ лечения (варианты)
EA200300183A1 (ru) Новое сочетание агониста (5-th2) и антагониста (5-ht6) серотонина в качестве фармацевтической композиции
EA199700111A1 (ru) Трициклические бензазепиновые антагонисты вазопрессина
NO944578L (no) Eksitatoriske aminosyre reseptor antagonister
EA199900206A1 (ru) Способ лечения обычной простуды или аллергического ринита
DK0556332T3 (da) Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet
DK0845988T3 (da) Hidtil ukendte kondenserede isoquinoliner som dopaminreceptorligander
ATE434437T1 (de) Verwendung von antagonisten der 5-ht3-rezeptoren zur behandlung von muskuloeskeletalen erkrankungen
EA200000322A1 (ru) Способ синтеза производных хинолина
BR9811348A (pt) Compostos derivados de indol, processo para preparação dos mesmos, e, composições farmacêuticas.

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU