EA022773B1 - Disinfecting composition - Google Patents

Abstract

The invention relates to practical medicine, in particular to bactericidal and washing agents for disinfection, sterilisation and pre-sterilisation cleaning of products for medical purposes (including combined in one process), for disinfection in veterinary, food industry, and can also be used at catering and sales facilities, markets, public catering organisations, transport and other objects of economic activity. The task of the invention is to develop a composition for disinfection, possessing a wide spectrum of action (bactericidal, antiviral, fungicidal, sporocidal), which makes it possible to carry out disinfection, sterilisation and pre-sterilisation cleaning of products for medical purposes at room temperature, with reduced exposure time in a working solution with higher stability and with simultaneous simplification of the disinfecting solution composition. The set task is achieved by that the disinfecting composition, which contains acid, hydrogen peroxide, functional additives and water, as acid contains glycolic acid with the following component ratio, wt.%: glycolic acid 2.0-35.0; hydrogen peroxide 1.5-35.0; functional additives 0.25-0.5; distilled water the remainder. The disinfecting composition can additionally contain cation-active SAS in quantity of 1-30 wt.%. Combination of glycolic acid with hydrogen peroxide in said concentrations makes it possible to obtain the disinfecting agent with higher stability of working solutions and wide range of action with respect to bacteria, spores, fungi and viruses, which is not characteristic of separate components, and with considerably reduced exposure time (1-30 minutes instead of 1-6 hours), which makes it possible to carry out disinfection of various surfaces in faster and more effective way and makes it possible to extend sphere of application and purpose of the disinfecting composition - application in medical practice for high level disinfection and sterilisation of products for medical purposes. The product is a concentrate, from which working solutions, concentration of which depends on etiology of microorganisms to be eliminated, are prepared by dilution with water.

Description

The invention relates to the development of a composition for disinfection, sterilization and pre-sterilization cleaning, which also has a detergent effect. The product is effective against bacteria, viruses, spores, fungi of various etiologies and can be used for disinfection (including combined with pre-sterilization cleaning) and sterilization of medical devices; for disinfection of surfaces and equipment in healthcare organizations of any specialization; in veterinary medicine, food industry, public catering, trade, markets, food units, transport, in greenhouse-greenhouse farms and other objects of economic activity and veterinary and sanitary supervision.

From literary sources known disinfectant Diastrile based on glycolic acid, the manufacturer Fresenius Medical ΚΕΑ A1 apb Κο.ΚΙ aA (Germany), designed to disinfect the circuit of the dialysis fluid hemodialysis apparatus [1].

However, this tool is used at a temperature of 84 ± 1 ° C, which requires complex technological support to maintain the temperature regime.

Hydrogen peroxide is a known disinfectant with sporocidal activity [2]. The drug is safe for the environment, since its decomposition products are water and oxygen, and is low toxic to humans.

However, hydrogen peroxide solutions have several drawbacks that inhibit their use: high corrosion activity in relation to materials from copper and carbon steels; hydrogen peroxide solutions readily decompose in the absence of stabilizers.

Known disinfectant solutions based on dilute solutions of hydrogen peroxide [3]. However, they are poorly stored and quickly lose their activity, especially if the disinfectant comes into contact with metals that catalyze the decomposition of hydrogen peroxide in the solution or on the treated object. The exposure time required to sterilize objects with such solutions is long (from 3 to 6 hours).

A known composition [4] to obtain a disinfectant preparation containing hydrogen peroxide, lactic acid, catamine, Trilon B, citric acid, sodium diphosphate and water, which is used to disinfect equipment, pipelines, surfaces at food enterprises, as well as for veterinary disinfection. The disadvantage of the drug is the lack of sporocidal activity, low stability of working solutions (7 days), the drug is characterized by significant corrosion activity in relation to metals. The closest in technical essence to the intended composition (prototype) is the well-known sporocidal disinfectant (patent KI No. 2224547). It contains a dilute solution of hydrogen peroxide and a mixture of acids: formic, oxalic, phosphoric, taken in the following proportions, wt.%: Hydrogen peroxide - 9.5-14.0; formic acid - 1.0-5.0; oxalic acid - 0.01-2.5; phosphoric acid - 0.01-10.0; distilled water - the rest. The tool can be supplemented with a surfactant. The disadvantage of the drug is its complex composition and the use of strong (orthophosphoric) acid in its composition. When inhaled, the drug has an irritating effect on the mucous membranes of the eyes and upper respiratory tract. The above sporocidal disinfectant has a high exposure time in working solutions (1 h) and it takes a long time to prepare it (the composition is kept for 1 h to form an active substance), which significantly degrades labor productivity.

The objective of the invention is to develop a composition for disinfection with a wide spectrum of action (bactericidal, antiviral, fungicidal, sporocidal), which allows for disinfection, sterilization and pre-sterilization cleaning of medical devices at room temperature, with a reduced exposure time (exposure) in a working solution with a higher solution stability and at the same time simplifying the composition of the disinfection solution.

The problem is achieved in that the disinfecting composition containing acid, hydrogen peroxide, functional additives and water, contains glycolic acid as an acid in the following ratio, wt.%:

glycolic acid 2.0 to 35.0; hydrogen peroxide 1.5 - 35.0; functional additives 0.25 - 0.5; distilled water - the rest.

The disinfecting composition may additionally contain cationic surfactants in an amount of 130 wt.%.

The combination of glycolic acid with hydrogen peroxide in this concentration allows you to get a disinfectant with higher stability of working solutions and a wide spectrum of action against bacteria, spores, fungi and viruses, not inherent in individual components and with a significantly reduced exposure time (10-30 min instead of 1 -6 hours as with the known analogues and prototype), which allows more quickly and efficiently disinfect various surfaces and expand the scope of the claimed disinfectant composition - and use in medical practice for high level disinfection and sterilization of medical devices.

- 1 022773

The author has established:

glycolic acid exhibits a synergy of antimicrobial activity in combination with other ingredients (in particular, the disinfecting effectiveness of glycolic acid is enhanced in the presence of hydrogen peroxide);

the combination of glycolic acid, hydrogen peroxide and a functional additive used in the claimed invention allows to optimize the disinfecting ability of the composition and increase the shelf life of the concentrate of the claimed solution to 18 months, and the working solution to 14 days.

The purpose of the claimed composition is determined by the above active principle (glycolic acid and hydrogen peroxide), other components are introduced into the composition as functional additives (complexing agents, stabilizers).

As functional additives, the disinfectant composition contains sodium benzoate or phosphonic acid.

An additional introduction of a solution of cationic surfactants in an amount of 0.1-30 wt.% Provides the disinfecting composition with wetting and washing properties, thereby achieving a more effective implementation of the disinfecting properties.

The inventive disinfectant composition is prepared by mechanical mixing of these components at room temperature. The product is a concentrate from which working solutions are prepared by dilution with water, the concentration of which depends on the etiology of the microorganisms to be destroyed. The shelf life of the concentrate of the claimed drug is 18 months, and the working solution is 4 days.

The invention is illustrated by the following examples.

Example 1

We prepare the product concentrate by sequentially dissolving in a small amount of water a functional additive (sodium benzoate) - 0.5 wt.%, Glycolic acid - 35 wt.%, Hydrogen peroxide - 35 wt.%, And bring water to 100 wt.%.

Example 2

We prepare the product concentrate by sequentially dissolving in a small amount of water a functional additive (sodium benzoate) - 0.25 wt.%, Glycolic acid - 2 wt.%, Hydrogen peroxide - 1.5 wt.%, And bring water to 100 wt.% .

Example 3

We prepare the product concentrate by sequentially dissolving in a small amount of water a functional additive (sodium benzoate) - 0.25 wt.%, Glycolic acid - 2 wt.%, Hydrogen peroxide - 35 wt.%, And bring water to 100 wt.%.

Example 4

We prepare the product concentrate by sequentially dissolving in a small amount of water a functional additive (sodium benzoate) - 0.25 wt.%, Glycolic acid - 35 wt.%, Hydrogen peroxide - 1.5 wt.%, And bring water to 100 wt.% .

Example 5

We prepare the product concentrate by sequentially dissolving in a small amount of water a functional additive (phosphonic kilot) - 0.25 wt.%, Glycolic acid - 2 wt.%, Hydrogen peroxide 1.5 wt.%, And bring water to 100 wt.%.

Example 6

The composition according to example 1-5 is additionally introduced cationic surfactant (alkylbenzyldimethylammonium chloride) 1 wt.%.

Example 7

The composition according to example 1-5 is additionally introduced cationic surfactant (alkylbenzyldimethylammonium chloride) 30 wt.%.

Example 8

The composition according to example 1-5 is additionally introduced cationic surfactant (didecyldimethylammonium chloride) 1 wt.%.

Example 9

The composition according to example 1-5 is additionally introduced cationic surfactant (didecyldimethylammonium chloride) 30 wt.%.

Example 10

The composition according to example 1-5 is additionally introduced cationic surfactant (didodecyldimethylammonium chloride) 1 wt.%.

Example 11

The composition according to example 1-5 is additionally introduced cationic surfactant (didodecyldimethylammonium chloride) 30 wt.%.

Example 12

The composition of example 2 was used after 18 months. after manufacturing.

A further decrease in the concentration of the substances specified in example 2 does not provide specified in

- 2 022773 tab. 1 properties of working solutions, and a further increase in the concentrations of the substances indicated in example 1 is not advisable, because does not significantly affect the increase in the antimicrobial activity of the composition, but only leads to a deterioration in economic and toxicological indicators.

Evaluation of the antimicrobial activity of the proposed disinfectant composition described in examples 1-12, and the prototype are presented in the table.

The effectiveness of the proposed tool and prototype in relation to microorganisms

Type of infection Means Prototype Exposure nation (minutes) Concentra- nation working solution mass% Exposure nation (minutes) Concentra- nation working solution mass% Mycobacteria thirty 2.0 60 4.0 E. coli pseudomonads, staphylococcus, shigella, salmonella thirty 0.1 60 2.0 Candidates thirty 1,0 There is no data Aspergillus thirty 5,0 There is no data Spores (Bacillus) thirty s oh 60 15.0 Viruses (including pathogens enterovirus infections, including causative agents of poliomyelitis, as well as herpes simplex, influenza) thirty 0.25 There is no data Pre-sterilization cleaning up 10 0.25 There is no data

Based on the data presented, the author found that the claimed disinfectant composition has a wide (bactericidal, fungicidal, antiviral, sporocidal) spectrum of action and provides fast, irreversible inactivation of microorganisms at a reduced exposure time in a working solution at room temperature. The functional additive used in the composition allows to increase the stability of solutions with higher acid concentrations, which allows to increase the disinfecting properties of the claimed composition. In contrast to the prototype, the disinfectant composition can be effectively used in medical practice for high level disinfection and sterilization of medical devices. The solution has low corrosivity, which is due to the presence of glycolic acid in its composition [5]. The inventive disinfectant is environmentally friendly, in vivo decomposes into harmless chemicals. The storage time of the disinfectant is 18 months.

The advantages of the proposed tool in comparison with the prototype

1) A simpler composition.

2) Reduced exposure time.

3) An extended spectrum of action (pre-sterilization cleaning of medical devices).

4) Increased stability of the disinfectant composition and working solutions.

5) Environmentally friendly: does not harm the environment, because completely decomposes into non-hazardous substances.

6) Non-toxic: it has low volatility in the preparation and use of working solutions, does not contain strong and toxic acids.

7) Provides safety and durability of equipment.

Literature:

1) The register of products that have passed state registration in the Russian Federation, certificate number 77.99.36.2.U. 1425.2.09 dated 02/16/2009

2) Buyanov V.V., Nikolskaya V.P., Pudova O.B., Suprun I.P., Titova K.V. Peroxysolvates in disinfection. Chernogolovka, 2000, p. 137.

3. A collection of the most important official materials on disinfection, sterilization, disinfestation, disinfestation / Under the general editorship of the academician of the RAMS MG Shandaly. -Volume II (Disinfecting and sterilizing agents. Disinfection, pre-sterilization cleaning and sterilization of medical products 3 022773 for medical purposes) - M., LLP, 1994.

4. Patent No. 13828 C1, MKI A 61b 2/16, 2010.

5. Dupont Chemical Solutions, 2006.

Claims (2)

1. A disinfectant for disinfection, sterilization and pre-sterilization cleaning, which has a wide spectrum of action against bacteria, spores, fungi and viruses on any surface, containing acid, hydrogen peroxide, functional additives and water, characterized in that it contains glycolic acid as an acid , in the following ratio of components, wt.%: glycolic acid 2.0-35.0; hydrogen peroxide 1.5-35.0; functional additives 0.25-0.5; distilled water - the rest. 2. The composition according to claim 1, additionally containing cationic surfactants in an amount of 1-30 wt.%. Eurasian Patent Organization, EAPO