EA003646B1 - Liquid delivery container - Google Patents

Abstract

1. Container for storing and ejecting liquid, the container comprising a) a front wall having or surrounding a cavity corresponding to the form of an open vessel, b) an opening in the front wall adapted for ejection of the liquid from the container, said opening defining a container axis, c) optionally a sealing over the opening adapted for temporary use, and d) a rear wall closing and sealing the open part of the front wall vessel to confine a space for the liquid in the container, the rear wall running at least partially perpendicular to the container axis and being displaceable or deformable for movement towards the opening to pressurize the container liquid, characterized in the improvement comprising, that the front wall is substantially rigid in relation to the rear wall, that the rear wall before pressurizing the container is substantially flat or substantially single-curved and that the rear wall is deformable under stretching to substantially fill out the container cavity. 2. The container of claim 1, characterized in that the cavity has the form of a generally concave deepening when seen from the rear wall side. 3. The container of claim 1, characterized in that the cavity has little, and preferably no, undercut parts when seen from the rear side. 4. The container of claim 1, characterized in that the front wall has a roughly constant thickness when measured normal to the cavity surface towards the front wall. 5. The container of claim 1, characterized in that the front wall has thickness, as measured normal to the cavity surface towards the front wall, increasing when moving away form the axis. 6. The container of claim 1, characterized in that the front surface of the front wall is substantially flat or substantially single-curved, at least in the area around the opening. 7. The container of claim 1, characterized in that the rear surface of the front wall is substantially flat or substantially single-curved, at least in the area around the cavity. 8. The container of claim 1 characterized in that the front and rear surfaces of the front wall in the neighborhood of the cavity, but disregarding cavity and opening as such, are substantially parallel or concentric. 9. The container of claim 8, characterized in that the front wall has the overall shape of a plate or cylinder part. 10. The container of claim 1, characterized in that the opening duct has a cross-section which is one of roughly constant, roughly converging, roughly diverging or a combination thereof. 11. The container of claim 1, characterized in that the opening is designed to assist in atomizing the liquid. 12. The container of claim 1, characterized in that the opening is designed to assist in forming a coherent linear liquid stream. 13. The container of claim 1, characterized in that the front wall front side has a cut-out area around the opening. 14. The container of claim 1, characterized in that the container is connected to at least one other container to form a multiple container unit. 15. The container of claim 14, characterized in that the front wall surface of several containers lies in the same flat or single-curved plane. 16. The container of claim 15, characterized in that the front wall surfaces of several containers are covered by a single sheet material. 17. The container of claim 14, characterized in that the rear wall surface of several containers lies in the same flat or single-curved plane. 18. The container of claim 17, characterized in that the rear wall surfaces of several containers are covered by a single sheet material. 19. The container of claim 14, characterized in that the unit is a substantially rigid and self-bearing structure. 20. The container of claim 19, characterized in that that the unit comprises an enlarged front wall structure in which several cavities with openings are provided to form the multiple containers. 21. The container of claim 20, characterized in that the front and rear surfaces of the front wall structure are substantially parallel in the neighborhood of the cavities, when disregarding the cavities and openings as such, to give a general plate form. 22. The container of claim 21, characterized in that the front wall structure has the overall shape of a disc. 23. The container of claim 22, characterized in that the several containers are positioned along at least one circle concentric with the disc periphery. 24. The container of claim 20, characterized in that the front and rear surfaces of the front wall structure are substantially single-curved and concentric in the neighborhood of the cavities, when disregarding the cavities and openings as such. 25. The container of claim 24, characterized in that the front wall structure has the overall shape of a full or partial cylinder. 26. The container of claim 25, characterized in that the several containers are positioned over two dimensions of the cylinder surface. 27. The container of claim 1, characterized in that the rear wall is folded in a continuous or discontinuous manner. 28. The container of claim 1, characterized in that the rear wall has substantially the same overall shape as the rear surface of the front wall. 29. The container of claim 1, characterized in that the rear wall is designed to be deformed elastically. 30. The container of claim 1, characterized in that the rear wall is designed to be deformed inelastically or permanently. 31. The container of claim 1, characterized in that the rear wall comprises a laminate. 32. The container of claim 1, characterized in that the rear wall comprises a metal layer. 33. The container of claim 1, characterized in that a temporary sealing is provided over the opening. 34. The container of claim 33, characterized in that the sealing is rupturable or removable. 35. The container of claim 33, characterized in that the sealing comprises a flat or single-curved sheet. 36. The container of claim 1, characterized in that the liquid volume is less than 25 microliter, preferably less than 15 and most preferably less than 10 microliter. 37. The container of claim 1, characterized in that the opening diameter is between 10 and 1000 micron, preferably between 20 and 800 micron. 38. The container of claim 1, characterized in that the font wall thickness is between 0.5 and 10 mm, preferably between 1 and 5 mm. 39. The container of claim 1, characterized in that the maximum cavity diameter is about 1 to 20 mm, preferably between 2 and 10 mm. 40. Container for storing and ejecting liquid, the container comprising a) a front wall having or surrounding a cavity corresponding to the form of an open vessel, b) an opening in the front wall adapted for ejection of the liquid from the container, said opening defining a container axis, c) optionally a sealing over the opening adapted for temporary use, and d) a rear wall closing and sealing the open part of the front wall vessel to confine a space for the liquid in the container, the rear wall running at least partially perpendicular to the container axis and being displaceable or deformable for movement towards the opening to pressurize the container liquid, characterized in the improvement comprising, that in the vicinity of the cavity the front wall has the overall shape, except for the cavity itself, of a flat or single-curved plate with substantially parallel or concentric front and rear surfaces, that at least a part of the cavity is formed between the front and rear surfaces with the opening exposed on the front surface and the open part of the vessel exposed on the rear surface, and that the rear wall being attached to the rear surface. 41. The container of claim 40, characterized in any characteristic of claims 1 to 39. 42. Container for storing and ejecting liquid, the container comprising a) a front wall having or surrounding a cavity corresponding to the form of an open vessel, b) an opening in the front wall adapted for ejection of the liquid from the container, said opening defining a container axis, c) optionally a sealing over the opening adapted for temporary use, and d) a rear wall closing and sealing the open part of the front wall vessel to confine a space for the liquid in the container, the rear wall running at least partially perpendicular to the container axis and being displaceable or deformable for movement towards the opening to pressurize the container liquid, characterized in the improvement comprising, that the front wall thickness, as measured along lines running through the cavity and normal to the vessel closed surface, increases when moving off-set from the container axis. 43. The container of claim 42, characterized in any characteristic of claims 1 to 39. 44. A method for manufacture of a container containing liquid, the container comprising a) a front wall having or surrounding a cavity corresponding to the form of an open vessel, b) an opening in the front wall adapted for ejection of the liquid from the container, said opening defining a container axis, c) optionally a sealing over the opening adapted for temporary use, and d) a rear wall closing and sealing the open part of the front wall vessel to confine a space for the liquid in the container, the rear wall running at least partially perpendicular to the container axis and being displaceable or deformable for movement towards the opening to pressurize the container liquid, characterized in the steps of, forming a front wall with a cavity in the form of a vessel with an opening connecting the vessel with the front wall front surface, introducing liquid into the vessel cavity, and attaching and adhering a flat or single-curved rear wall film to the vessel cavity open part to enclose the liquid in the container. 45. The method of claim 44, characterized in the step of forming the front wall with cavity and opening by injection molding. 46. The method of claim 44, characterized in the step of adhering the rear wall film by welding. 47. The method of claim 46, characte

Description

The present invention relates to pressures in which pressure can be created and which are intended for storing and supplying liquid, wherein the container contains a) a front wall having or surrounding a cavity corresponding to the shape of an open vessel, b) an opening in the front wall intended to be dispensed liquids from the container, with the opening defining the axis of the container and the front wall to limit the space for fluid inside the container, while the back wall at least partially extends perpendicular to the axis of the container and is displaced or deformed to move to the orifice to create pressure of the fluid in the container. The invention also relates to methods for manufacturing a container, as well as to methods and devices for ejecting liquid from containers.

Background to the invention

For containers with liquid, designed not only for holding and storing the liquid, but also for supplying or ejecting liquid, there is a tendency to increase their complexity when the requirements for the supply scheme increase. Although complexity and high cost, for example, in pumping systems under certain conditions may be acceptable, for example, in the case of reusable devices or devices for multiple dosing, these conditions do not always occur. For example, it is often necessary to provide one compacted container for each delivered dose of fluid, for example, to accurately control the dose and maintain sterility up to the point of use in the case of medical use, and with such single doses, the price limit becomes decisive. The design constraints become even stricter if you add requirements regarding delivery quality, such as supply pressure, fluid velocity, aiming accuracy, jet continuity, speed of increase and decrease in flow, flow rate, small losses, metering accuracy, etc. High pressures in the chamber, for example, to ensure high jet velocities or spraying degrees, may contradict the cost aspect because of the need to create thick walls with special design or complex supports for the chamber or contradict the requirement of providing a given trajectory of movement due to destruction, instability or offset holes. Ensuring the continuity of the jet may require the creation of a precise orifice channel, which is inconsistent with the requirement of using a minimum amount of material and with manufacturing conditions. High dosing accuracy requires complete emptying of the chamber and obtaining small losses, which, in turn, requires rapid creation and pressure drop, as well as high requirements for cavity stability and controlled deposition of the pressure wall. Secondary factors should also be taken into account. For example, it is common practice to provide a temporary seal over the opening in order to completely seal the container before it is used, and there must also be a device for breaking or removing the seal when feeding occurs. In addition to the properties of the container, a certain stiffness and additional structures may be required to hold the container in the fixture or seat of the device. In order to avoid manipulation of individual containers with single doses, it is also necessary to create blocks of a large number of connected containers for their sequential use in the dispenser, which may require imparting additional structural rigidity and providing features for feeding individual containers to the position of using the device and their stability in this position. Manufacturing requirements include both efficient production of container parts, and rational filling, and container sealing in conditions of high purity and even sterility.

Known sentences meet the above requirements only to a limited extent. US Pat. No. 4,090,642 describes a tape having a large number of pockets for a flowable material, which is a liquid dispensed with low feed and control requirements, since the flowable material is only squeezed onto the surface of the tape for use by skin contact. US Pat. No. 5,497,763 describes a system comprising a similar tape with a large number of doses for spraying a liquid that is intended for inhalation. However, the requirements for submission are low, since sputtering takes place with a separate vibrator, and the tape is required to reduce the output fluid flow through the porous membrane. GB Patent Description 2255918 simply refers to drop formation for inhalation, however, the spraying of liquid here takes place by means of its forced supply through the narrow openings of the container. Despite the increased requirements, the proposed containers are separate flexible containers or sheets with a large number of bubble-shaped containers that require strong support in the dispenser when they apply pressure to the dome-shaped rear wall, the curvature of which cannot be fully controlled. It should also be noted that, for the purposes described, it is not necessary to specify the trajectory of the movement of the liquid and the formation of the flow of the liquid, since in the case of inhalation the droplet fog passively retracts into the patient’s lungs, even ensuring redistribution of the flow. The same applies to powder inhalers, such as those described in international publication ν090 / 13328, UK patent 2242134, Germany display 19500726, international publication \ νθ97 / 04827. US Patent 4,811,731, US Patent 5,207,217; US Patent 5,415,162; European Patent 4,69814; European Patent 129985; and US Patent 4,627,432, in which spraying does not occur at all, and there is no release from nozzle-type openings. Accordingly, these requirements are not taken into account in them and the design of the container necessary for such purposes is not intended. International publication 96/00050 and European patent 224352 describe the formation of a droplet flow, active ejection, ensuring a given trajectory of movement to the eye and the ability to intersect the air gap by means of its own inertia. However, usually the required dispensers are complex, and there are no proposals for containers with built-in delivery nozzles for individual unit doses. In international publications ν096 / 06581 and ν097 / 23177, single dose containers have been described for similar purposes in the treatment of eyes. Although in many respects the proposed container designs are commendable, they are similar to the already known and discussed structures, i.e., complex individual containers or flexible strips with a large number of bubble-type pockets having balloon-type walls that are designed to settle them.

Accordingly, there is a need to create advanced systems with combined, compacted containers for single doses, suitable for storing and delivering liquids and meeting high requirements for control and quality.

Summary of the Invention

The main objective of the present invention is to avoid the aforementioned disadvantages of containerized systems that have been used up to now. More precisely, the task is to create a system with sealed containers for single doses, suitable both for storing the liquid and for supplying it in compliance with high requirements for control and quality.

Another task is to create such a system that meets the high requirements in terms of fluid velocity, precise setting of the motion path, jet continuity, rapid increase and decrease in flow, feed rate, small losses, accurate dosing and / or complete emptying of the container. Another task is to create a system that provides high pressure in the chamber while maintaining the integrity of the container and without breaking, instability or displacement of the hole. Another challenge is to create a system that enables controlled deposition of the pressure wall. Another task is to create a system used to obtain different values of the amount of movement of the fluid flow, for example, characterized as low, medium and high, which allow the use of fluids from smooth application to strong penetration. Another task is to create a container system from a material with low cost, in the manufacture of components and in filling. Another challenge is to create containers with high rigidity and stability. Another task is to create such container structures that are suitable for blocks with a large number of containers used for the sequential delivery of doses. Another task is to create containers that allow to simplify the design of the metering device and require limited support when serving. Another challenge is to create a system that is easy to manipulate and convenient to work for the end user.

These objectives are achieved through the distinctive features indicated in the claims.

By using a deposited back support wall that seals the container, which has a generally flat or single-curved shape before deposition, the necessary accuracy is achieved. For each general shape of the front wall, the back wall will have a minimal surface that ensures stability of volume and shape before deposition, as well as predictable and controlled deposition during pressure build-up in the container, since there is no need to warp, bend or shrink the wall, as with the corresponding deformations of the wall in case of its straightening or inverse transformation. The stretchable wall material allows it to increase its surface during bending, thereby avoiding a rupture and allowing the plunger or hammer-type tool surface to dynamically influence it to force the wall to move and to match the opposite surface of the container cavity, all of which serve for controlled reactions on the effect of pressure, including the beginning of its creation, its continuation and discharge, as well as for precise dosing and emptying a trainer. Advantages related to production, among other things, are achieved due to the fact that the shape of the wall facilitates the process of its manufacture, its sealing against the front wall during filling and its attachment to several containers in blocks or packages with a large number of cells. The advantages relating to the convenience and construction of the dispenser, as well as its manipulation, are achieved due to the fact that the initial shape of the wall can be used to obtain smooth surfaces of the rear wall and it does not create along the edges of the material used for the design of the front wall with vessels. This front wall is based on the total static and dynamic stiffness of the container. In contrast to bubble-type containers, the proposed vessel wall can be arbitrarily constructed and does not necessarily depend on the curvature of the preloaded structures to provide rigidity, can have a thickness in each of its places corresponding to the functional purpose, should not have local weakening during tensile operations and can be completed for one hole with it, which is determined by design, not production requirements. Wall stability is important for controlling volume and the possibility of sequential emptying. The strength of the wall and the hole is important for resistance to the action of pressure, to ensure the working range of the system, to reliably set the trajectory of motion, as well as for the stability and continuity of the jet of fluid. This also reduces the need for extended support devices for the containers in the dispenser and facilitates the subsequent delivery of the containers to the ejection position. If the advantages provided by the liquid are used in order not to use the balloon-shaped parts of the wall, then the seat under the container in the dispenser and the feeding mechanism can be further simplified. At the same time, it is possible to create blocks with a large number of containers without limitation by ribbons or other flexible structures, and to obtain advantages, self-supporting structures with improved characteristics in terms of handling and convenience similar to those of individual containers can be formed. The vessel wall can be made, for example, as a final design when forming the container cavity in the form of a different, flat or single-curved plate, providing blocks with single containers as well as with a large number of containers with high structural rigidity and simple external shape, advantageous with respect to manufacturing, design of the dispenser and manipulation of them by the end user, and with the possibility of arbitrary creation of cavity structures, for example, to ensure appropriate topics and flow characteristics suitable design the external part of the device and for receiving hole structures of any length and shape of a high dynamic stability. Such advantages are achieved when the vessel is made with substantially constant wall thickness or with increasing wall thickness when passing laterally from the location of the hole in the wall. The walls of vessels with a hole in the proper place can be made as a single-piece structure from one material, for example, by thermal formation in ordinary plastics processing devices, and without the need for tensile operations or separate stages of nozzle formation, the vessels are easily filled with liquid and compacted through the back wall.

Other objects and advantages of the invention will be apparent from the detailed description below.

Definitions

The expression “single-curved” is used here to be understood as any form of a plane or surface that can be obtained from the same plane in a flat form, and without stretching or tightening any part of it in any direction within the plane, i.e. preservation of the total surface for the entire plane, as well as any part of it. On the contrary, a “bent-bent” plane or surface can only be obtained from the plane when it is deformed by stretching or tightening. Curvature should be considered "continuous" if it is constant or has a smooth change, and should be considered "intermittent" if there is a sharp change in the direction of the plate. As physical, non-limiting examples, a cylindrical surface or a wavy surface is a single-curved surface, since it can be formed from an inelastic sheet, for example, from a sheet of paper, by simple bending, while the surface of the sphere or the surface of the saddle cannot formed in a similar way without stretching and, accordingly, is a two-curved surface. All these surfaces are continuous due to the presence of smooth changes in curvature, while, for example, sheets with sharp folds are intermittent at the fold lines.

As used herein, the term “system” should be understood as referring to the invention as a whole, including parts thereof, such as a container and, consequently, dispensers, as well as methods of working and using parts.

In the absence of precise expressions of reverse meaning, expressions used here are similar to the expressions "containing", "including", "having", "c" and similar terms should be understood not as referring exclusively to the listed elements, but as ensuring the availability of other elements, as well as as covering any element in holistic, subdivided or cumulative forms. Similarly, expressions such as "connected", "attached", "located", "attached", "between" and similar terms should be understood not as covering only direct contact between the listed elements, but as ensuring the possibility of having one or more intermediate elements or designs. The same applies to similar expressions used to describe forces or actions.

In addition, the expressions used here relating to the location and direction of both the container and the feeding device, such as "front", "rear", "forward", "back", should be understood as referring to the direction of flow of the fluid, in relation to which the line centered in the container opening and drawn along the main or averaged flow direction should be considered the “axis” of the system along which the fluid is flowed in the forward direction.

Detailed description

The container may include a front wall and a rear wall, between which there is a container space or enclosed space for the liquid in it.

The container space is formed mainly between the front wall and the rear wall and includes a cavity part formed in the front wall or surrounded by the front wall. Although the space available for the liquid may be larger than the volume of the cavity itself, for example, by an additional small volume in the hole and in the back ledge or curvature of the back wall, it is preferable that the cavity constitutes a large part of the space, especially in the case where the back wall preferably, essentially, is a flat or single-curved wall. The surface of the cavity preferably has a configuration of the space of the vessel, going to the rear wall and having a closed bottom part directed to the front wall. Among other things, to facilitate complete emptying and mutual adaptability of the cavity and the actuating plunger, it is preferable that the cavity has a small amount, and preferably does not have any, with recesses, when viewed from the rear. This can be achieved by means of the surface parts of the vessel parallel to the cavity axis, for example cylindrical parts, however, it is preferable that the surface expands all the way from the axis outwards in the lateral direction in order to create a concavity recess, as viewed from the side back wall. Although the surface may have sharp bends, for example, between an axially extending cylindrical surface and a flatter front part, preferably, for example, for reasons of stiffening, so that the surface is substantially smooth and continuous. The shape of the cavity in the cross-sectional planes perpendicular to the axis can be any, for example, oval or polygonal, although it is preferable that it is round. Acceptable common forms are the shape of a dome or segment of a sphere. It is known in itself that the space can be divided into two or more separate chambers, for example, for sequential feeding or for mixing when feeding, for example, by using internal walls running parallel or perpendicular to the axis. Such walls can be removed manually before the actual execution of the feed, or they can be destroyed during the feed. Alternatively, adjacent containers can contain different liquids and push them out essentially simultaneously, for example, in the form of two separate jets or jets mixed when pushing, for example, through holes arranged with displacement and close to each other or directed towards each other .

Preferably, the front wall has greater rigidity than the rear wall due to the content of more rigid materials and / or materials with larger dimensions in thickness. Therefore, it is advisable that the front wall imparts rigidity and stability to the container and its opening, and it is preferable that one front wall could impart such rigidity, leaving the possibility for arbitrary use of the rear wall construction, based on other considerations. If these requirements are met, the front wall can have a variety of configurations. The front wall may have an approximately constant thickness, measured along the normal to the surface of the cavity, making the shape of the front wall approximately the same as the surface of the cavity. However, it is preferable that the wall thickness, measured as above, has a change, and approximately such that it increases off-axis. This, for the container as a whole, provides a good opportunity to impart a predetermined trajectory of movement and steady pressure retention and allows you to create a hole design for short-term and low friction. This contrasts sharply with blister-type containers, when the manufacture of a can with the stretching performed results in wall parts weakened in the lateral direction and to a very low overall stability of the container. The preferred layout method in the event of such a change in wall thickness is to make the front surface of the front wall preferably flat or single-curved, with a flat implementation being more preferable since it allows you to get many advantages in terms of manufacturing and handling. It is also preferable that the posterior surface of the front wall near the cavity and independently of the cavity itself is also made single-curved, and most preferably it is made flat, providing similar advantages in terms of manufacturing and handling. Among other things, flat or single-curved surfaces provide the ability to attach to them initially flat sheets, films or foils without stretching, for example, a sealing film on the front surface of the back wall and on the back surface of the front wall. Most preferably, the anterior and posterior surfaces, respectively, are parallel or concentric, allowing structures, for example of a generally flat or cylindrical type, to be obtained, possessing proper properties in terms of rigidity, the possibility of their manufacture and manipulation.

The design of the orifice can be changed depending on the nature of the fluid flow created, for example, fine spraying or a concentrated flow to maintain its continuity or to divide it into linear flows consisting of individual drops. In addition, the flow rate can vary from high, providing penetration, to low for submission in order to influence the surface. Multiple or multiple holes may be made, for example, to obtain a controlled shower stream, although in most cases one hole is preferred. The hole geometry may be the same as that of a simple tube, with a divergence, for example, to ensure distributed spraying, with convergence, for example, to ensure the continuity of the flow being formed, or it is a combination of them, for example, for a channel like a venturi. It is usually preferable that the flow part of the hole is short in order to maintain low friction with the flow. The third thickness of the front wall in the orifice zone can be controlled, for example, in order to obtain proper stiffness, for example, by cutting around the hole, preferably on the front surface of the front wall, also contributing to the mounting of the film above the hole in a manner that does not interfere with the hole itself. The location of the opening with respect to the cavity may be asymmetric, for example offset laterally to the side of the cavity, for example, to mix adjacent jets, although it is usually preferable that the opening is symmetrical with respect to the cavity, for example concentric with the symmetry of the cavity.

Although the above considerations apply to individual containers for single and separate use, it is preferable to create multi-container blocks or packages. This can be accomplished by joining several separate containers into composite structures, for example, by means of flexible joints to form structures that can be bent, folded, or folded. However, it is preferable that the composite container package is essentially a rigid, self-supporting structure, among other things, providing advantages regarding the feeding device. A rigid structure can be obtained by coupling individual containers using rigid connections, however, the preferred method is to use the stiffness of the front wall, which is described by creating an enlarged front wall design and creating several cavities in the design, which, among other things, simplifies the manufacture of large the number of containers and provides smooth and uncomplicated external contours. By using the feature relating to the manufacture of the front and / or rear surfaces of a flat or single-curved construction of the front wall, the attachment of films to these surfaces is further simplified, especially if the container surfaces lie in the same plane, because then to several, and preferably to all individual containers the structure may be attached undivided sheet material, for example, a conventional foil attached as a back wall to the back surface of the structure, For conventional cover sheet over the hole at the front surface.

The overall shape of the front wall design for a large number of containers may be different. A single-curved shape may, for example, be a partial or full cylinder shape, providing a large number of containers in a limited volume and creating a very rigid structure. The container openings may be located on the outside of the cylinder, for example, if the dispenser plunger is positioned to strike from the inside or the concave side of a full or partial cylinder, or if the holes are diametrically opposite to each rear wall to access the plunger from the outside of the cylinder. The openings of the container can be located on the inside of the cylinder, for example, for easy access of the external plunger to the rear wall, in which case a diametrically opposite opening can also be made for the passage of a jet of liquid. The advantages in terms of manufacturing and construction of the feeder device are mainly provided by structures with a flat front wall. The shape may be, for example, rectangular, square or round. As found, a particularly advantageous round “disc” shape is applied to a feeding device, in which the consecutive supply of containers to the ejection position can be accomplished by simply rotating the “revolving type”, while the absence of any particular starting position facilitates the execution of devices for manipulating and counting, and gives self-centering properties.

Placing a large number of containers on the existing surface of the structure can be done in different ways. Containers can be arranged in a row or along a line in order to avoid feeding in two dimensions. Alternatively, several rows can be made along several lines in two dimensions, for example, parallel or concentric, which makes it possible to obtain a compact arrangement of containers.

The above design considerations concerning the front wall are generally applicable to the parts occupied by the containers; however, other structures can be introduced to achieve additional tasks, for example, to grip, hold, center or feed individual or multiple containers during manufacture, in the supply device or a user, for applying or removing a sealing film, etc., and these parts can be arbitrarily designed to perform the respective tasks.

The front wall is preferably made of suitable plastics, such as polyethylene or polypropylene, possibly with reinforcing fillers, such as fiberglass, while it can be made in various ways, for example, cavities with a hole can be made by machining the raw material, and the structures described can be easily formed in a single stage, for example, by pressing, although it is preferable that this is done by injection molding, since all the Kurtura, including the hole, can be obtained with a split molding tool. Although the front wall can be made of a layered structure or other composite material, usually a single material is sufficient.

As indicated, the back wall serves to seal the back of the container before ejecting the liquid and allows the cavity to wrinkle during ejection. The rear wall, at least partially, should be angled with respect to the axis of the hole, that is, with the formation of an angle different from zero between them, while it is preferable that it extends substantially perpendicular to the axis. The requirements for the back wall material for sealing purposes depend on the specific application and the fluid used, however, it is usually desirable that the wall material is substantially impermeable. It is also desirable to avoid the use of solvents and other volatile components, moreover, both in the wall material and when attaching the back wall to the front wall, and it is preferable that the connection of these parts is carried out by means of heat sealing, rather than glue or binders. For the purpose of deposition, it is possible to have a back wall material that breaks or collapses when it is hit by a dispenser plunger, which, however, requires a good seal between the plunger and the cavity. Therefore, it is preferable that the back wall can be deformed without destruction, and most preferably, it deforms to such an extent that it expands and corresponds to the internal surface of the cavity. Requirements for deformability can be reduced if the back wall film is bent, for example, by giving continuous waviness or by continuous bending, that is, in both cases while maintaining a single-curved shape, for example, along one or more parallel lines over each container, to ensure deployment as part of the deformation. However, in order to provide the most controlled and reproducible deposition, it is preferable that no additional folds are used, but that the back wall, when attached, preferably has the same shape as the back surface of the front wall. In any case, the deformation during ejection leads to the fact that the rear wall, having a flat shape or a single-curved shape, at least to some extent turns into a double-curved shape, which requires some stretching of the material. Stretching and deformation can be elastic, as in the case of a rubber sheet, for example, if reuse is intended, but it is preferable that plastic be used at least partially, and more preferably in a substantially irreversible manner, to avoid reuse of disposable container or to prevent air or liquid residues from being drawn into the container after use. The back wall is preferably in the form of a sheet, film or foil of uniform thickness, which preferably should be small compared with the front wall. The sheet may consist of one material, however, it is preferable to use a composite material to meet all the requirements. Most preferably, the sheet is a layered structure. Preferably, the layered structure consists of at least one impermeable and diffusion-suppressing layer, preferably a metal layer, such as an aluminum layer, and at least one tensile layer that allows for deformation, preferably a plastic layer, such as polyethylene, and, as an option, also from a layer compacted by heat, if the plastic layer does not possess this property. In such a layered structure, it is allowed that during the deposition of the wall a metal layer breaks, since the other layers have sufficient elasticity during the described deformation.

As indicated, it is preferable to temporarily seal the opening or openings of the container before actually expelling the liquid, in order to keep the container in a state of complete sealing. The seal must be destroyed or removed immediately before use. Although a seal can be used that is destroyed manually or under pressure, it is often preferable to use a removable seal in order to avoid the appearance of any particles detachable from the seal to provide fully predictable dynamic behavior and use of more reliable thick and durable layers. In general, a seal may be formed integrally with the front wall, for example, by means of such formation, so as to leave a membrane of material somewhere in the opening channel. However, it is preferable that a separate tear-off layer is provided for its removal before pushing out, which is preferably superimposed on the front surface of the front wall. It is preferable to avoid the use of glue and binders, while it is preferable to use a certain type of welding, such as ultrasonic or heat welding. To simplify the removal as well as the elimination of interference in the area of the hole, a seal can be made to limit the area surrounding the hole. In designs with a large number of containers, it is preferable to create layers that are individually removed for each container, for example, by using separate films, pre-cut films or separate tongues, for example, in the form of a star for a circular disc. Similar considerations for film material can also be attributed to the back wall material, although the film does not necessarily have to be deformed by stretching, and the requirements for impermeability can be slightly understated due to the small opening area.

The parts described must be connected and the cavity must be filled with liquid to form a pre-filled, sealed container, usually containing a liquid to deliver a single dose. Although it is possible to fill the container cavity through an opening, for example, by means of a needle, the preferred method is to fill the cavity from the back of the front wall before attaching the back wall. Further, the operation consists in attaching a sealing film over the hole or holes, possibly using welding, filling the container cavity from the rear with liquid and attaching the back wall above the filled cavity, and again with the possible use of welding. Preferably, these steps are carried out in the order mentioned. In the invention it is possible to use several ways for the efficient and simplified execution of such an operation, in particular, as compared with the production and filling in the case of blister-type containers. In contrast to bubble-type cans, flat sheet materials can be used as a sealing film and back wall, allowing attachment along a plane or a single curvature using equally simple flat or roller tools, and making it possible to attach over several containers in multi-container structures. , while there is no need to stretch or to perform other stages of deformation of the material. Acceptable welding effects, such as thermal effects, are individually applied to the sealing film and to the rear wall, respectively, and directly to the adjacent materials used, while in the case of manufacturing bubbles, the heat that seals the front and rear materials must act through the surface layer, over-joining this layer, which delays the process, probably affects the existing fluid and leads to an increase in tolerances on the product.

A feeding or dispensing device designed to push fluid out of containers, in general, can comprise a housing with a seat for a container or container structure, a plunger that can move relative to the housing towards the container in a substantially axial direction when it is in the seat and drive unit for driving the plunger.

The term "hull" should be understood in its broad sense, with the hull having various forms. The housing of the device is the original location for the location of the container and the implementation of the described movements, such as a plunger used to deposit the rear wall of the container and to perceive the forces applied by the driving means performing the movements, the force being applied between the housing and the movable part. The minimum functional requirement is that the housing creates a support or platform for the container and moving parts, as well as for the driving means providing movements and forces. However, as in the case of the usual practice, it is preferable that the body forms a container that at least partially covers the parts, and preferably to the extent that only those elements that are intended to control or control the operator are exposed, allowing the design , in general, convenient to use.

The housing must contain a seat for the container or for several containers, the minimum requirement for which is to ensure that at least the container that is intended for emptying is kept stationary relative to the plunger, and it is preferable that the axis of the container parallel to the axis of movement of the plunger, and most preferably, it should be coaxial with the part of the plunger that serves to strike the rear wall of the container. Preferably, the footprint can accommodate containers with the characteristics described herein, i.e., the exemplary shapes and sizes. The seat preferably keeps the container from the influence of the forces acting in the forward direction created by the plunger, and preferably also from the action of certain forces having rear and lateral directions. Preferably, the seat allows the entire rear wall surface above the cavity to be exposed with respect to the plunger, and also allows at least the opening or openings on the front side of the container to be left out without creating an obstruction to the fluid flow, although the rigidity of the containers offered does not require using any powerful prop. Preferably, the designed seat also provides the possibility of easily replacing individual containers or sequentially moving individual containers of the multi-container structure to an active position in the seat, for example, by having a movement track along which the structure can move in one or two directions. In a preferred embodiment, the containers are arranged in a circle, preferably on a disc-shaped structure, wherein the disk can be appropriately rotated around its central axis in a revolving type to center the containers with the place in which they are driven. For arrangements with one, and especially with a large number of containers, it is desirable that guide devices are used to ensure the required coincidence with the plunger axis in order to achieve the required very accurate feeding, for example, designs created together with each container of the package for interaction with at least one an appropriate locking structure on the housing, on the seat or on the plunger designed to be blocked with proper centering. Blocking can preferably be interconnected with the signal to ensure that it stops at the proper position, for example, with a tangible or audible signal when operated manually or with a mechanically or electronically detectable signal during automatic operation. In addition, it is preferable to introduce a counting device, manual or automatic, mechanical or electronic, designed to preserve the track for a certain number of containers used or remaining, and to warn of reuse or to prevent reuse of already empty containers.

The plunger may include a head and a piston device for moving the head along the axis of movement. Although it is possible to design a plunger head that does not correspond to the container cavity, for example, to use it with different cavity forms, or based on the stretching properties of the rear wall during emptying, it is preferable to design it so that the cavity is completely filled. This can be done through a soft or adjustable plunger head, for example, to ensure compatibility with different cavity shapes, in order to increase the working range or to ensure a certain emptying, preferably squeezing the fluid from the peripheral parts of the cavity to central, axial parts, such as can be implemented by making the shape of the soft head of the plunger somewhat smaller than the shape of the cavity of the vessel. However, in the case of a single cavity shape, it is preferable to perform the front surface of the piston head substantially identical to the internal surface of the cavity or the rear surface of the front wall in the container space. The plunger head may be surrounded by a support, such as a tubular structure, in which the head moves and which preferably also adjoins the cavity to seal the space between the plunger head and the cavity, at least during the back wall sedimentation movement, for example, to provide high pressure or reduce leakage hazard. The piston part of the plunger, which will be described in conjunction with the actuation system, usually does not affect the pushing dynamics and serves only to transmit motion.

The plunger can be set in motion through the use of a variety of mechanisms and energy sources. The mechanism can be directly actuated by manual energy, however, in this case it is preferable to provide a lever system or a gear change system for changing or transforming a force or speed, and it is preferable to lower the speed or increase the force. In order to have controlled and consistent results, it is usually preferable to have an automatic function in that the operator will automatically advance, preferably irreversible, through the use of stored energy. Energy can be stored in any way, for example by means of a mechanical spring, a gas spring or a gas generator, electrical energy, or a combination thereof. Energy can be transferred to the plunger using an appropriate motor or transmission means, for example, respectively from an electric motor or a solenoid type motor in the case of electrical energy, a piston and cylinder device in the case of gas springs or gas generators and a rotation axis or rod for cylindrical and helical springs . It is usually preferable to embed a transmission between the engine tool and the plunger itself in order to increase the force, for example, by using a transmission with gear wheels or cam surfaces. Preferably, during the forward movement, the rotation of at least the head of the plunger, and preferably the parts of the piston part of the plunger, is impeded, which can be done using known guide structures, for example, a non-rotatable symmetric part interacting with the mating part. these parts are placed respectively on the plunger and on the body. The preferred element of the transmission, which serves to communicate the movement of the plunger, is a device consisting of a screw and a nut, with one of the parts placed on the plunger and the other on the transmission from the engine side. The necessary characteristics regarding speed, force and displacement of the plunger depend on a certain number of conditions, such as the type of container parts and openings, the particular application, for example, to be applied to the surface or for penetration, the viscosity of the preparation, for example, aqueous solutions or ointments, etc. , while the general information about them is not given. However, energy sources, engine equipment and transmissions can be used for every necessary case. It has also been established that it is advantageous to build in a damper, for example, a shock absorber, a linear damper, a flow regulator, a magnetic damper, etc., to control the speed while maintaining the stability of the force. In most cases, it is desirable that there is a rapid increase and drop in pressure, usually requiring stable and not slowing down the plunger speed, which is easier to achieve, for example, by means of a damper or due to the high inertia of the plunger and transmission.

It is also preferable to embed fixtures in the device to facilitate the destruction or removal of the described temporary seal installed over the openings. Although it is possible to break the seal by means of the pressure itself, created when the back wall is deposited, it is preferable to use an active stage to break the seal. This can be done with a tool that removes the seal, which is located together with the housing, for example, a penetrating tool for a breakable seal, or a wedging or pulling device for removing peelable sealing films. Such devices can be located on or near the landing place, for example, for a later action or a remote action, for example, if the seat is crowded. The tool for removing compaction can be activated manually, or automatically, or forcibly, for example, as part of the movement of the container to the landing place. However, it has been found that it is preferable to position the tool for removing the seal on the back side of the container for moving from the rear side forward, which allows the tool for removing the seal to act on the film in the best possible way, that is, on the back side of the film to lift it from the front surface of the front walls. It also provides the possibility of a more convenient location of the tool and mechanism inside the case and behind the container for less interference in the ejection zone and on the trajectory of movement during ejection. The tool may have its own movement mechanism, however, it is more preferable that the tool be located on the plunger or with the plunger so that it moves with the plunger using the same moving mechanism and facilitating removal just before pushing as an inevitable part of the procedure pushing out. Preferably, the tool to remove the seal passes through the hole in the structure of the front wall, and possibly also through the back wall in a place not occupied by the container cavity, but covered with a sealing film. It is preferable that the dimensions of such a hole and a seal removal tool match each other, so that these parts act as the described guide device for the final centering of the plunger and the cavity before actuating the device. When working with a tool, the film is first lifted from the opening of the container, and then the plunger head hits the back wall of the container. It is possible to perform these two stages by means of one continuous movement of the plunger, for example, to most easily perform the operation and remove the compaction as late as possible, or a two-stage operation may require the user to perform two starting actions, for example, in order for the user to be convinced that the film is properly removed. . It may also be of interest to use different movement characteristics for two stages, for example, slow movement when separating a layer, so as not to cause rupture or destruction, and fast movement for pushing, when using a switching device, for example, a device for switching gears, disconnecting a brake or a damper, etc. d. The general design principles of the container according to the present invention greatly enhance the advantages described above by means of stiffness, allowing the front wall to be used to give direction, and the possibility of using zones outside the cavity part without problems associated with instability.

Depending on each application, it is also possible to equip the device with means for setting the motion path and positioning. For example, when the device is used to inject fluid into the eye, the front of the device is equipped with a cap, element, or cup to abut the eye socket. In applications where penetration is ensured, a small distance or direct contact between the hole and the target surface may be required, while processing a large surface may require an end element defining the angle and distance. With respect to dispensers, it is known that the devices may also include mechanical or electronic means of warning, signaling or timing.

As indicated in the introductory part, the invention described here can be used for various purposes both within the medical sphere and outside it for different types of preparations, for example for chemical preparations, composites or mixtures, and in any quantity and supplied for different purposes. It can be used for liquids in a wide range of their compositions, for example, for pure liquids, solutions, emulsions, dispersions, body fluids, etc., and in a wide range of viscosities, for example, for ointments having high viscosity. Therefore, the system is characterized by certain special values related to medical delivery devices, in which the restrictions imposed on the structure are stricter than for other uses. For convenience, the invention has been described using terminology relating to medical use.

The preferred use of the invention relates to the treatment of the eye on the basis of ophthalmology with medications. Conventional treatments are performed with eye drops or ointments, however, they have some drawbacks. Both of these methods usually involve delivering a much larger amount than that which can be absorbed by the eye, which leads not only to dosing uncertainty and the loss of an expensive medication, but also to potentially possible side effects when the unabsorbed drug flows through the nasal canal. for example, a beta-blocking agent used to treat the eyes, with a significant systematic effect. Another problem is that conventional treatments lead to the tendency for the blink reflex to occur, which can completely disrupt the treatment or at least introduce a significant degree of uncertainty. In addition, conventional methods do not provide a high degree of accuracy in the specification of the trajectory of movement, that is, the ability to accent the iris of the eye, which is the permeable part of the eye for prostaglandin. The principles used in the present invention solve these problems through the possibility of supplying small amounts of liquid, actively pushed out and not determined by surface tension of fluids, the possibility of supplying liquid with sufficient speed to suppress the blink reflex and the possibility of pushing out a concentrated and non-breaking flow to accurately set the motion path. Typical parameters for such an application will be given below, although the invention should not be considered limited to these given as an example parameters. A typical volume of a single dose for delivery to the eye may be less than 25 μl, preferably less than 15 μl, and most preferably less than 10 μl. Typically, the volume is at least 1 μl, preferably at least 2 μl, and most preferably at least 3 μl. Since it is desirable that each container contains a single unit dose, these figures also refer to the volumes of liquid filled into and inside the containers, and with some possible overflow to compensate for non-pushed quantities, for example, liquid remaining as a wetting film or in the opening channel container, while the overflow is, for example, 25%, and preferably not more than 10%. Along with the liquid, the container may contain other materials, namely gas, such as air, or treatment gas, such as nitrogen, or inert gases, to, for example, facilitate manufacture, facilitate spraying, or act as a pressure buffer, although in many cases a small amount of gas or it can not be. The maximum diameter of the container cavity is, for example, approximately from 1 to 20 mm, and preferably it is between 2 and 10 mm, while it is calculated for a surface equivalent to a circle if the cavity is non-circular. Acceptable flow rate of droplets or ejected jet must be balanced so that, on the one hand, sufficient linear driving force is provided for crossing the air gap between the hole and the object, and without the assistance of gravity and for sufficiently fast movement, which is not hampered by blinking, and, on the other hand, the speed should not be very high so as not to create an impact on the eye that causes discomfort. The ideal speed is such a speed, which to some extent depends on the size of the drops used, and, as a rule, the drops should be able to pass through the air 1 cm, preferably at least 3 cm, and most preferably at least 5 cm due to its own amount of movement, based on the distance between the hole and the object. Acceptable lower speed limit when leaving the hole is 1 m / s, preferably 5 m / s, and most preferably at least 10 m / s. Typically, the speed is less than 200 m / s, and preferably less than 100 m / s. The suitable droplet size thus formed should be sufficient so that the droplets are not too quickly slowed down and the direction changes freely, for example by inhalation, it is preferable that the minimum droplet diameter is about 20 μm, preferably not less than 50 μm, and most preferably at least 100 microns. Typically, the size is less than 2000 microns, and preferably less than 1500 microns. The flow may take the form of a shower or spraying from small drops of liquid, but it is preferable that the flow be narrow and completely inseparable, although even such a flow tends to separate into separate drops after passing a certain distance. It is assumed that the above values refer to spherical droplets, and for a large number of droplets to the particle diameters with average weight. The continuous flow tends to separate into droplets, the diameter of which is approximately twice the diameter of the flow. Accordingly, the acceptable opening diameters of the containers are approximately half the diameter of the droplets, or between approximately 10 and 1000 μm, and preferably between 20 and 800 μm. Acceptable thickness of the front wall from the front of the hole to the rear wall may be in the range from 0.5 to 10 mm, and is preferably from 1 to 5 mm. The above data is completely independent of the viscosity of the liquid and can be attributed to both solutions and ointments.

Summary of figures

FIG. The 1L-1O schematically shows the cross-sectional views of various container designs, as well as the distinctive features used in layouts with one container or with a large number of containers.

FIG. 2A-2C show a rear view, a diametrical section and an enlarged fragment of a structure with a large number of containers, made in the form of a disk, having 14 containers distributed along the periphery of the disk.

FIG. 3Α-3Ό show views of a disc similar to the disc in FIG. 2, in perspective and in partial sections, also showing the back wall and peelable film.

FIG. 4A-4B respectively show a partial sectional view and a perspective view of the internal parts of the dispenser for a large number of disc-type containers.

Description of figures

In all embodiments of the construction according to FIG. 1, with the exception of the embodiment shown in FIG. 1E, the front wall is designed as a plate-type construction, or flat, as in FIG. 1A, 1B, 1Ό and 1E, or curved to obtain concentric surfaces, as in FIG. 1C and 1C. The figures show various significant distinguishing features, however, in all these figures, for their clarity, not all the necessary or proposed details are shown.

According to FIG. 1A, container 110 includes a front wall 111 having a front surface and a back surface that are substantially parallel to each other. The front wall 111 has a cavity 112 in the shape of a vessel with a front surface 113 and an opposite rear opening 114. The cross section of the cavity shown is generally in the shape of a circular segment. An opening 115 defining the container axis 116 provides fluid communication between the inside of the cavity and the outside of the front side of the front wall. Hole 115 is shown here in the form of a channel having a virtually constant cross section, with a thin inner membrane 117 made of the material left during injection molding, and acting as a temporary seal that is broken when pressure is created in the cavity. The deformable rear wall 118 covers with a seal (not shown) the rear opening 114 of the vessel with a cavity. The back wall is formed from an initially flat sheet material, shown here with a discontinuous curvature in the form of a certain number of folds 119, running perpendicular to the plane of the figure, while the folds act in such a way as to reduce the required tension of the back wall material when it is forced into the container cavity.

FIG. 1B shows a container 120, similar to the container shown in FIG. 1A, except that the opening 125 is shown to converge slightly and is covered on the front surface of the front wall with a temporary seal in the form of a breakable or peelable sheet 127 compacted relative to the front surface of the front wall. The back wall 128 is shown as a film with a continuous curved part 129 providing additional volume relative to the volume provided by the vessel while being limited by the back hole 124, in this case indicated by a dotted line running flush with the back surface of the front wall, while the back wall has an additional surface limiting its stretching. The curvature of the rear wall portion 129 can be provided by a flat sheet material, if this curvature is constantly perpendicular to the plane of the figure, as in the case of a cylindrical surface, however, if it is in the form of a can, then a double curved material is required.

FIG. 1C shows a container 130 formed in the front wall 131, mainly in the form of a cylindrical part with single-curved front and rear surfaces centered around a cylindrical axis 133, and with a hole 135 on the convex outer cylindrical surface. A cavity 132 is also shown, having a cylindrical portion 134 ending in the form of a segment segment 137 of a sphere, with both parts symmetrically centered around the axis 136 of the hole 135. The rear wall 138 is formed of a single-curved material that is continuously bent to fit the front-side cylindrical wall 131, while representing a larger surface than the corresponding flat sheet above the opening of the vessel with a cavity, which is indicated by the dotted line 139.

FIG. 1Ό shows a container 140 with a front wall 141 having a cavity 142, the surface of which has a cylindrical part 143 and a flat part 144. A hole 145 is also shown with a recess 146 surrounding it on the front surface of the front wall serving to avoid direct contact between the hole itself and peelable film 147, as well as its sealing surface 148, which is located in the form of a ring on the outer side of the recess 146.

FIG. 1E schematically shows a container 150 with a cavity in the shape of a circle segment, as in FIG. 1A and 1B, centered relative to the center point of the 153 circle. The radius lines 154 of the structure, extending from point 153, intersect the inner surface 155 of the cavity 152 along the perpendicular, and the figure shows that the wall thickness, if measured along these lines along the normal to the surface of the vessel, increases (solid parts of the line 154) laterally from cavity axis 156. In contrast, in FIG. 1E shows an embodiment of the construction of the container 160 in which the cavity 162 is formed in the front wall 161, designed to ensure its constant thickness if measured along the lines 164 centered at the point 163 in the same manner as in FIG. 1E. This figure also shows the longer bore of the opening 165, which has a converging part 166 and a straight part 167 with an approximately constant cross section. For clarity of figures, the section lines are not indicated on them.

FIG. 16 shows the container 170 formed in the front wall 171, mainly in the form of a cylindrical portion, as in FIG. 1C, with the single-curved front and rear surfaces centered around the cylindrical axis 173. However, in this embodiment, the opening 175 is located on the inner, concave cylindrical surface. The rear wall 178 is formed from a single-curved material that has a continuous bend to fit the cylindrical outer surface of the front wall 171, while it has a larger surface than the corresponding flat sheet above the vessel with a cavity 172. In addition, from a single-curved sheet material a temporary sealing film 177 is also formed, covering the opening 175.

All embodiments of the container construction shown in FIG. 1A-16 may be used as individual containers alone or may be part of multi-container structures when combined with containers of a similar or other type indicated as indefinite lateral extensions of the front walls shown.

FIG. 2A, 2B, and 2C show a rear view, a diametrical section, and an enlarged fragment of a structure with a multi-container front wall in disk shape having 14 containers distributed along the periphery of the disk. The disk, generally designated by the position 200, includes a peripheral design 210 of the front wall with containers, a slightly offset central auxiliary part 230 with devices for actuating and holding and a transition part 250 with devices for peeling and giving direction. In the illustrated embodiment, the plate-shaped base form of the front wall construction 210 has a front side 211 and a rear side 212 and contains 14 identical cavities 220, essentially in the form of circle segments, the rear edge 221 of which is slightly rounded. The holes 222 of the cavities slightly converge, and a small recess 223 is made on the front side 211 of the front wall construction 210. The additional part 230 may include a central axial hole 231, designed to support and actuate, with a keyed surface 232, made asymmetrical to facilitate actuation . Preferably, the hole 231 is made with a certain taper and converges from the back to the front, in order to simplify the insertion and centering of the drive unit. The protrusions 233 spaced apart from each other serve to provide a gap between the discs when they are stacked, for example, during sterilization. The transition portion 250 may include channels 251, also somewhat converging in the forward direction and serving to allow penetration of the sealing tool from the rear side to the front side in order to lift the temporary seal in the form of a peelable film (not shown), while the interaction between the tool and channel also contributes to giving direction, centering the cavity with respect to the head of the dispenser plunger. With the cavity arrangement shown, a flat rear film (not shown) may be positioned above the rear sides of the cavities to seal the containers, for example, after filling. Each cavity can be sealed with separate parts of the film, however, it is also possible to use a single sheet to cover all cavities. Preferably, such films are radially limited to the front wall portion 210 on the disk, leaving the transition part 250 and the additional part 230 uncovered. A typical front wall plate thickness may be about 2 mm with a cavity depth on the order of 1.5 mm.

FIG. 3Α-3Ό shows the disk layout similar to that of FIG. 2. In FIG. 3A is a perspective view of the front side of the disc; FIG. 3B is a perspective view of the rear side; FIG. 3C shows a section from the periphery of the disk to its center through the cavity before expelling, and FIG. 3Ό shows a similar section of the cavity after its use. As in FIG. 2, the disk has a peripheral design 310 of the front wall with containers slightly displaced in the transverse direction, a central accessory portion 330 with driving and restraining devices, and a transition part 350 with devices for peeling off and giving direction. All parts that are shared with those shown in FIG. 2, not re-shown. In addition, in this embodiment, there are 14 identical cavities 320, essentially in the form of circle segments, with openings 322 having recesses 323 on the front side. Holes 311 serve to facilitate disc manipulation, for example, during manufacture and filling. In this case, the additional part 330 has a central axial hole 331 for supporting and actuating, and with 14 symmetrically positioned teeth 332, allowing the disk to be attached to the corresponding gear axis of the dispenser without taking into account the location of any separate container or part disk. The transition part 350 has channels 351, which are designed to allow the sealing tool to penetrate from the rear side towards the front side in order to lift the temporary seal in the form of peeling film. A single flat back wall film 370, cut to the shape of a ring and radially limited to the front wall structure 310, covers all rear sides of the cavity to seal the containers. As seen in FIG. 3A, a peelable film 390 is attached to the front side of the disc in order to cover the openings 322 of all the cavities. The peelable film is formed in the form of a star from a flat single sheet and contains a uniting central annular part 391, concentrically attached to an additional disk part 330, and tabs 392 extend radially from the annular part, one for each cavity, so that they extend over the transitional part 350, passing over the channels 351, and then exiting in the radial direction to cover the openings 322 of the cavities. Initially, all the openings 322 of the cavities are covered with tongues 392. When liquid from one of the containers is to be fed, the tool for removing the seal (not shown) is moved through the corresponding channel 351 from the back side of the disk to its front side, thereby lifting the corresponding tab 392 'to release the opening openings 322 of the corresponding cavity, as shown in FIG. 3A and 3Ό. After that, the contents of the container are pushed out by forcing the rear wall 370 to be stretched from the flat state shown in FIG. 3C, to the state of filling the cavity shown in FIG. 3Ό.

FIG. 4A and 4B show a dispenser for discs with a large number of containers, which are described with reference to FIG. 3. The device, generally designated 400, is shown without any body part or housing. A disk 410 enters the device from its front side, to the right, if you look at the figures. The device includes a seat 420 of the disk containing the supporting axis 421 having teeth 422 corresponding to the teeth of the central opening of the disk. Axle 421 has a carrier gear 423, interacting with the control gear wheel

424 coupled to a wheel being gripped

425, serving to sequentially move the individual containers to the ejection position. The wheel to be gripped may be manually actuated or may be connected to a mechanism (not shown) for automatic discrete movement associated with the engine actuation cycle. The ratchet mechanism 426 allows the disk to occupy only target positions and only rotate in one direction, in order to avoid the reuse of already empty containers. These parts may also contain counting tools and other auxiliary means (not shown) operated to replace the disk. According to the figures, the lowermost part of the disk is in the active position 427 to perform the ejection, while the seat may contain additional support for the disk or means to give it direction (not shown), for example, to counteract forward movement, and possibly backward, for example , for balancing the force generated by the plunger. Preferably, such support structures can be located on the door of the housing, which serves to insert the disc. In this position, the cavity is centered with respect to the plunger, generally designated 430. The plunger includes a head 431 with a front shape in the form of a circular segment that is consistent with the shape of the cavity of the container. The plunger head is a part of the support 432, also carrying a tool for removing compaction and giving direction, made in the form of a finger probe 433, designed to penetrate the channels corresponding to the channels 351 in FIG. 3, in the disk 410 for lifting a temporary sealing film from the opening of the container, as well as centering and stability of the container cavity with respect to the plunger head 431. The fingertip 433 extends in the forward direction further than the plunger head 431, in order to fulfill the aforementioned functions, before the plunger head hits the back wall of the structure. The plunger further comprises an external screw thread 434 for its translational movement back and forth in the axial direction. The plunger is fixed to prevent its rotational movements by giving direction (not shown) to the flat bottom surface 435 of the plunger head support 432. The device further comprises an engine and transmission system, in general, indicated by

450 and serving to drive the plunger. The rotatably mounted but axially fixed nut 451 has an internal screw thread 452 for engagement with the external screw thread 434 of the plunger in order to move the plunger in the axial direction while rotating the drive nut. Articulated viscous damper 453 has a fixed part 454 and a rotational part 455 connected to the drive nut 451, so that it rotates together with the drive nut. Drive nut

451 has external gear teeth 456, by means of which the nut can be rotated. The rotatably mounted motor housing 460 has an outer gear 461 with a larger diameter than the drive nut 456. Inside the motor housing 460 there is a spring 462, which can be cocked by rotating the winding axis (not shown) passing through the open portion 463 of the housing 460 engine left, if you look at the figures. A motor 464 with a rim groove 465 is rigidly attached to the motor housing 460 and arranged concentrically with it, for engagement with the cocking finger 466 of the safety switch 467 accessible to the hand. Impact system 470 includes a descent system (not shown) with a release button 471 having two actuating positions, the first for partial operation by a release button, allowing the engine and transmission system 450 to advance the plunger to move the fingertip 433 to completely remove the temporary sealing film, but without contact between the rear wall of the container and the plunger head 431, and the second operating position of this trigger button 471, ensuring that the plunger head 431 moves toward the container cavity, to to shown in FIG. A typical plunger advancement speed during the pushing operation may be, for example, about 2 mm at a time of about 50 m / s, with a cavity depth of about 1.5 mm.

The invention is not limited to the embodiments described and the examples presented, and may be modified within the scope of the appended claims.

Claims (92)

1. A container for storing and supplying fluid containing a) a front wall having or a surrounding cavity corresponding to the shape of an open vessel, b) an opening in the front wall designed to allow liquid to exit the container, the hole defining the axis of the container, c) as an option, a seal over the opening for temporary use, 6) a rear wall covering and sealing the open part of the vessel of the front wall to limit the space for liquid in the container, while the rear wall at least partially extends perpendicular to the axis of the container and mixes henna or deformed to move to the hole to create fluid pressure in the container, characterized in that the front wall is made essentially rigid with respect to the rear wall, the back wall is flat or substantially single curved before the pressure is created in the container wall, the rear wall is deformed by stretching to fill the cavity of the container. 2. The container according to claim 1, characterized in that the cavity, in General, has the form of concavity, deepening when viewed from the side of the rear wall. 3. The container according to claim 1, characterized in that the cavity has minor recessed parts, and preferably excludes them, when viewed from the back side. 4. The container according to claim 1, characterized in that the front wall has an essentially constant thickness when measured along the normal to the surface of the cavity in the direction of the front wall. 5. The container according to claim 1, characterized in that the front wall has a thickness, if measured along the normal to the cavity surface in the direction of the front wall, increasing away from the axis. 6. The container according to claim 1, characterized in that the front surface of the front wall is a substantially flat or substantially single curved wall, at least in the region around the opening. 7. The container according to claim 1, characterized in that the rear surface of the front wall is made essentially flat or essentially single-curved, at least in the area around the cavity. 8. The container according to claim 1, characterized in that the front and rear surfaces of the front wall near the cavity are essentially parallel or concentric. 9. The container of claim 8, wherein the front wall is in the form of a plate or part of a cylinder. 10. The container according to claim 1, characterized in that the channel of the hole has a cross section that is approximately constant, approximately converges, approximately diverges, or is a combination thereof. 11. The container according to claim 1, characterized in that the hole is designed to ensure atomization of the liquid. 12. The container according to claim 1, characterized in that the hole is designed to ensure the formation of an inextricable linear fluid flow. 13. The container according to claim 1, characterized in that the front side of the front wall has a cut out area around the hole. 14. The container according to claim 1, characterized in that it is connected at least to another container to form a block with many containers. 15. The container according to 14, characterized in that the surface of the front wall of several containers lies in the same plane or in a single curved plane. 16. The container of claim 15, wherein the surfaces of the front wall of several containers are coated with a single sheet material. 17. A container according to claim 14, characterized in that the surface of the rear wall of several containers lies in the same plane or in a single-curved plane. 18. The container according to 17, characterized in that the surface of the back wall of several containers are coated with a single sheet material. 19. The container according to p. 14, characterized in that the block essentially is a rigid and self-supporting structure. 20. The container according to claim 19, characterized in that the block comprises an enlarged front wall structure in which several cavities are made with holes for forming a plurality of containers. 21. The container according to claim 20, characterized in that the front and rear surfaces of the front wall structure are substantially parallel to the cavities to provide a substantially plate shape. 22. The container according to item 21, characterized in that the design of the front wall, essentially, has the shape of a disk. 23. The container according to item 22, wherein the several containers are located along at least one circle concentric with the periphery of the disk. 24. The container according to claim 20, characterized in that the front and rear surfaces of the front wall structure are essentially single-curved and concentric near the cavities. 25. The container according to paragraph 24, wherein the design of the front wall, essentially, has the shape of a full or partial cylinder. 26. The container according A.25, characterized in that several containers are located in two dimensions of the surface of the cylinder. 27. The container according to claim 1, characterized in that the rear wall is bent in a continuous or intermittent manner. 28. The container according to claim 1, characterized in that the rear wall has essentially the same overall shape as that of the rear surface of the front wall. 29. The container according to claim 1, characterized in that the rear wall is made with the possibility of its elastic deformation. 30. The container according to claim 1, characterized in that the rear wall is designed for inelastic or permanent deformation. 31. The container according to claim 1, characterized in that the rear wall contains a layered structure. 32. The container according to claim 1, characterized in that the rear wall contains a layer of metal. 33. The container according to claim 1, characterized in that a temporary seal is made above the hole. 34. The container according to p, characterized in that the seal is made with the possibility of rupture or removal. 35. The container according to p. 33, characterized in that the seal contains a flat or single-curved sheet. 36. The container according to claim 1, characterized in that the liquid volume is less than 25 μl, preferably less than 15 μl, and most preferably less than 10 μl. 37. The container according to claim 1, characterized in that the diameter of the hole is between 10 and 1000 microns, and preferably between 20 and 800 microns. 38. The container according to claim 1, characterized in that the thickness of the front wall is between 0.5 and 10 mm, and preferably between 1 and 5 mm. 39. The container according to claim 1, characterized in that the maximum diameter of the cavity is from about 1 to 20 mm, and preferably is between 2 and 10 mm. 40. A container for storing and supplying liquid, containing a) a front wall having or surrounding a cavity corresponding to the shape of an open vessel, b) an opening in the front wall designed to push liquid out of the container, the hole defines the axis of the container, c) as an option , a seal above the hole intended for temporary use, b) a rear wall that covers and seals the open part of the vessel of the front wall, to limit the space for liquid in the container, while the back wall, at least The third measure partially extends perpendicular to the axis of the container and is shifted or deformed to move to the hole to create fluid pressure in the container, characterized in that the front wall near the cavity has a common shape, with the exception of the cavity itself, a flat or single-curved plate, essentially with parallel or concentric front and rear surfaces, at least a portion of the cavity is formed between the front and rear surfaces with an opening extending outward on the front surface and the open part of the vessel and, facing out on the back surface, a back wall attached to the back surface. 41. The container according to p, characterized in that it includes any of the signs according to PP. 42. A container for storing and supplying fluid containing a) a front wall having or a surrounding cavity corresponding to the shape of an open vessel, b) an opening in the front wall designed to push liquid out of the container, the hole defining the axis of the container, c) as an option, a seal over the opening for temporary use, b) a rear wall covering and sealing the open part of the vessel of the front wall to limit the space for liquid in the container, while the rear wall at least partially extends perpendicular to the axis of the container a and displaced or deformed to move toward the opening to create a fluid pressure in the container, characterized in that the thickness of the front wall, if measured along lines passing through cavity and perpendicular to the surface of the closed vessel increases in the direction from the container axis. 43. The container according to item 42, characterized in that it includes any of the signs according to PP.139. 44. A method of manufacturing a container containing a liquid containing a) a front wall having or surrounding a cavity corresponding to the shape of an open vessel, b) an opening in the front wall designed to push liquid out of the container, the hole defining the axis of the container, c) as an option , a seal over the hole intended for temporary use, ά) a rear wall covering and sealing the open part of the vessel of the front wall to limit the space for liquid in the container, while the rear wall at least partially the perpendicular to the axis of the container and offset or deformed to move to the hole to create fluid pressure in the container, characterized in that it includes the following stages: forming a front wall with a cavity in the form of a vessel with an opening connecting the vessel to the front surface of the front wall, introducing fluid into the cavity of the vessel, attaching a flat or single-curved film of the back wall to the open part of the cavity of the vessel to place the liquid in the container. 45. The method according to item 44, wherein the front wall is formed with a cavity and a hole by injection molding. 46. The method according to item 44, wherein connecting the film of the rear wall by welding. 47. The method according to item 46, wherein the welding by heat. 48. The method according to item 44, wherein the attach a flat or single-curved sealing film over the hole. 49. The method according to item 44, wherein the front wall is formed with more than one cavity. 50. The method according to 49, characterized in that they attach a film of the back wall over more than one cavity. 51. The method according to 49, characterized in that they attach a flat or single-curved film over more than one cavity. 52. The method according to item 44, wherein the container includes any of the signs according to claims 1-39. 53. A container containing a liquid, characterized in that it is made according to the method according to any one of paragraphs 44-52. 54. A method of ejecting liquid from a container, comprising a) a front wall having or surrounding a cavity corresponding to the shape of an open vessel, b) an opening in the front wall designed to eject liquid from the container, wherein the hole defines the axis of the container, c) as an option, a seal above the hole intended for temporary use; ά) a back wall that covers and seals the open part of the vessel of the front wall to limit the space for liquid in the container, while the rear wall At least partially extends perpendicular to the axis of the container and is shifted or deformed to move to the hole to create fluid pressure in the container, characterized in that it includes the following steps: creating pressure in the container by moving the back wall at least partially in the axial direction and to the hole at a sufficient speed to push the fluid through the hole, stretching the back wall, elastic or inelastic, to increase its surface. 55. The method according to item 54, wherein the stretching stage includes the stage of stretching the back wall from a flat or single-curved shape to a bent shape. 56. The method according to item 54, wherein the stage of stretching includes the stage of deformation of the rear wall to essentially match the shape of the cavity. 57. The method according to item 54, wherein the step includes the step of essentially removing liquid from the container. 58. The method according to item 54, wherein the liquid is pushed out of the hole at a speed of at least 5, and preferably at least 10 m / s. 59. The method according to item 54, wherein the liquid is ejected in the form of droplets with a diameter of approximately less than 20 microns. 60. The method according to item 54, wherein the liquid is expelled in the form of an inextricable stream. 61. The method according to item 54, characterized in that it allows the passage of fluid through the air at a distance of at least 1 cm before a collision with the target surface. 62. The method according to item 54, wherein the possibility of collision of fluid with the eye. 63. The method according to item 54, wherein the liquid is allowed to collide with a soft surface, at least for partial penetration through it. 64. A device for supplying liquid from a container containing a) a front wall having or surrounding a cavity corresponding to the shape of an open vessel, b) an opening in the front wall designed to push liquid out of the container, the hole defining the axis of the container, c) as an option , a seal over the hole intended for temporary use, ά) a back wall covering or sealing the open part of the vessel of the front wall to limit the space for liquid in the container, while the back wall at least partially perpendicular to the axis of the container and offset or deformed to move to the hole to create fluid pressure in the container, characterized in that it contains a housing with a seat for the container, designed to fit the container, in which the distance between the rear wall and the front surface of the front the wall is at least 0.5 mm, a plunger installed in the direction of movement relative to the housing, essentially axially to the container when in the seat, p ivodnoe device acting to drive plunger movement. 65. The device according to p. 64, characterized in that the container, when located in the seat, opens towards the plunger, essentially the entire part of the surface of the rear wall covering the cavity. 66. The device according to item 64, wherein the seat is located so as to provide the ability to replace the container in the seat. 67. The device according to p, characterized in that the seat is located so as to provide replacement by sequential supply of containers to the seat in the unit with many containers. 68. The device according to p, characterized in that the seat includes a track into which the container can be served. 69. The device according to p. 67, characterized in that the seat provides the possibility of sequential supply by rotation of the block with many containers, in which the containers are arranged in a circle. 70. The device according to item 64, wherein a guide device is installed to reliably center the plunger and the cavity of the container. 71. The device according to item 70, wherein the guide device includes a removable latch between the container and the housing or seat. 72. The device according to item 70, wherein the guide device includes a removable latch between the container and the plunger. 73. The device according to item 72, wherein the locking device includes a structure that secures the container when moving in the direction of movement of the plunger. 74. The device according to item 64, wherein the plunger includes a head and a piston. 75. The device according to p. 74, characterized in that the front of the plunger head essentially corresponds to the cavity of the container. 76. The device according to p. 74, characterized in that at least the front of the plunger head is made of soft material adapted to the cavity of the container. 77. The device according to item 74, wherein the drive device is designed to offset the piston of the plunger. 78. The device according to item 64, wherein the drive device includes an electrical device for driving the plunger in motion. 79. The device according to item 64, wherein the drive device includes a mechanical device for driving the plunger in motion. 80. The device according to p. 79, characterized in that the mechanical device contains at least one spring for storing energy. 81. The device according to item 64, wherein the drive device comprises a transmission comprising at least one device for converting the driving force into motion. 82. The device according to p, characterized in that the transmission includes a device consisting of a screw and a nut. 83. The device according to p. 64, characterized in that it includes a damper designed to influence the movement of the plunger. 84. The device according to p. 64, characterized in that it includes a seal-removing tool designed to break or remove the seal located above the opening of the container. 85. The device according to p. 84, characterized in that the tool is located behind the container when the container is in the seat and is designed to move forward during the removal of the seal. 86. The device according to p, characterized in that the tool is installed so that it passes through or behind the front wall during its movement forward to break the seal. 87. The device according to p, characterized in that the tool and the container are arranged so that they interact as a guide device designed to reliably center the plunger and the cavity of the container. 88. The device according to p, characterized in that the tool is connected to the plunger for general movement with him. 89. The device according to p, characterized in that the tool is connected to the plunger so as to hit the seal before the plunger hits the container. 90. The device according to item 64, wherein the container is any of the containers according to claims 1-39. FIG. 1A FIG. 1B * Ί3? FIG. 1C 91. The device according to p. 64, characterized in that it is designed to be able to supply fluid according to any one of paragraphs 54-63. 92. A kit or combination, characterized in that it contains a) a container according to any one of claims 1-39, b) a device containing a plunger designed to displace or deform the rear wall of the container to create fluid pressure in the container.