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DOP2017000189A - Compuestos de benzoxaborol y usos de los mismos - Google Patents

Compuestos de benzoxaborol y usos de los mismos

Info

Publication number
DOP2017000189A
DOP2017000189A DO2017000189A DO2017000189A DOP2017000189A DO P2017000189 A DOP2017000189 A DO P2017000189A DO 2017000189 A DO2017000189 A DO 2017000189A DO 2017000189 A DO2017000189 A DO 2017000189A DO P2017000189 A DOP2017000189 A DO P2017000189A
Authority
DO
Dominican Republic
Prior art keywords
compounds
same
structure comprises
whose structure
formula iii
Prior art date
Application number
DO2017000189A
Other languages
English (en)
Inventor
J Plattner Jacob
Li Xianfeng
Barros Aguirre David
Giordano Llaria
R K Dickon Alley M
Hernandez Vincent
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Anacor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55409879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2017000189(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip No 2 Ltd, Anacor Pharmaceuticals Inc filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of DOP2017000189A publication Critical patent/DOP2017000189A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/08Antibacterial agents for leprosy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/04Esters of boric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se proporcionan compuestos cuya estructura comprende la fórmula II: Fórmula II: o un compuesto cuya estructura comprende la fórmula III: Fórmula III en donde X se selecciona a partir de cloro, flúor, bromo y yodo, R1 y R2 se seleccionan cada uno independientemente a partir de H, -CH3, -CH2CH3, –CH2CH2CH3, o -CH(CH3)2; composiciones que los contienen, su uso en terapia, incluyendo su uso como agentes anti-micobacterianos, por ejemplo, en el tratamiento de una infección micobacteriana en un mamífero, y los métodos para la preparación de estos compuestos.
DO2017000189A 2015-02-12 2017-08-10 Compuestos de benzoxaborol y usos de los mismos DOP2017000189A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15382056 2015-02-12
EP15382055 2015-02-12
EP15382054 2015-02-12

Publications (1)

Publication Number Publication Date
DOP2017000189A true DOP2017000189A (es) 2018-02-15

Family

ID=55409879

Family Applications (2)

Application Number Title Priority Date Filing Date
DO2017000189A DOP2017000189A (es) 2015-02-12 2017-08-10 Compuestos de benzoxaborol y usos de los mismos
DO2017000188A DOP2017000188A (es) 2015-02-12 2017-08-10 Compuestos de benzoxaborol 4-sustituidos y uso de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
DO2017000188A DOP2017000188A (es) 2015-02-12 2017-08-10 Compuestos de benzoxaborol 4-sustituidos y uso de los mismos

Country Status (36)

Country Link
US (3) US10774096B2 (es)
EP (2) EP3256479B1 (es)
JP (2) JP2018506540A (es)
KR (2) KR20170117158A (es)
CN (2) CN107548398A (es)
AU (3) AU2016217508A1 (es)
BR (2) BR112017017213A2 (es)
CA (2) CA2976308A1 (es)
CL (2) CL2017002060A1 (es)
CO (2) CO2017008816A2 (es)
CR (2) CR20170371A (es)
CY (1) CY1123687T1 (es)
DK (1) DK3256479T3 (es)
DO (2) DOP2017000189A (es)
EA (2) EA201791667A1 (es)
ES (1) ES2821951T3 (es)
HR (1) HRP20201597T1 (es)
HU (1) HUE051113T2 (es)
IL (2) IL253865A0 (es)
LT (1) LT3256479T (es)
MA (2) MA41494B1 (es)
MX (2) MX2017010414A (es)
MY (1) MY194004A (es)
NZ (1) NZ734379A (es)
PE (2) PE20171348A1 (es)
PH (2) PH12017501428A1 (es)
PL (1) PL3256479T3 (es)
PT (1) PT3256479T (es)
RS (1) RS60885B1 (es)
SG (2) SG11201706511TA (es)
SI (1) SI3256479T1 (es)
SM (1) SMT202000565T1 (es)
TW (2) TW201702250A (es)
UA (1) UA120527C2 (es)
WO (2) WO2016128949A1 (es)
ZA (1) ZA201705456B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201914073PA (en) * 2013-08-09 2020-03-30 Glaxosmithkline Ip No 2 Ltd Tricyclic benzoxaborole compounds and uses thereof
LT3621609T (lt) 2017-05-08 2022-10-10 Glaxosmithkline Intellectual Property Development Limited Sanfetrinemas arba jo druska arba esteris, skirtas naudoti mikobakterinės infekcijos gydyme
AU2018375795A1 (en) 2017-11-30 2020-07-02 Boragen, Inc. Benzoxaborole compounds and formulations thereof
MX2021001904A (es) 2018-08-18 2021-05-27 Boragen Inc Formas solidas de benzoxaborol sustituido y composiciones de las mismas.
CN110441344B (zh) * 2019-06-25 2020-09-29 北京大学 一种基于固体核磁共振技术检测rna结构的方法
EP4384527A1 (en) * 2022-06-23 2024-06-19 Micurx Pharmaceuticals, Inc. Prodrugs of boron compounds and their use in treating bacterial infections
EP4384185A1 (en) * 2022-06-23 2024-06-19 Micurx Pharmaceuticals, Inc. Methods and uses of boron compounds in the treatment of nontuberculous mycobacterium infections and pharmaceutical compositions for treatment of same
KR20240150582A (ko) 2023-04-08 2024-10-15 김태서 맥세이프 배터리팩을 포함한 아이폰 케이스

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411587D0 (en) * 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
EP0947498B1 (en) 1996-12-02 2004-09-15 Chisso Corporation Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same
DE60313357T2 (de) 2002-12-02 2008-01-03 Solvias Ag Verfahren zur katalytischen hydrierung von kohlenstoff-heteroatom-doppelbindungen
NZ598441A (en) 2005-02-16 2013-07-26 Anacor Pharmaceuticals Inc Boron-containing small molecules
US7919422B2 (en) 2005-03-08 2011-04-05 Agency For Science, Technology And Research Chiral bisoxazoline catalysts
JP2009526751A (ja) 2005-12-30 2009-07-23 アナコール ファーマシューティカルズ,インコーポレイテッド ホウ素含有小分子
TWM325238U (en) * 2006-12-29 2008-01-11 Universal Scient Ind Co Ltd Voltage regulator and voltage regulating system
KR100848491B1 (ko) 2007-01-16 2008-07-28 영진약품공업주식회사 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
PE20120052A1 (es) 2008-12-17 2012-02-13 Anacor Pharmaceuticals Inc Polimorfos de (s)-3-amino-metil-7-(3-hidroxi-propoxi)-3h-benzo-[c][1,2]-oxaborol-1-ol
WO2011037731A1 (en) * 2009-09-25 2011-03-31 Anacor Pharmaceuticals, Inc. Boron containing small molecules
MX352607B (es) * 2010-04-07 2017-11-30 Glaxosmithkline Llc Star Proceso para la preparacion de benzoxaboroles.
EP3251678B1 (en) * 2010-09-07 2021-10-20 Anacor Pharmaceuticals, Inc. Benzoxaborole derivatives for treating bacterial infections
CA2858799A1 (en) 2011-12-22 2013-06-27 Micurx Pharmaceuticals, Inc. Tricyclic boron compounds for antimicrobial therapy
CN102739587B (zh) 2012-06-16 2014-05-21 天地融科技股份有限公司 音频数据传输方法
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
SG10201914073PA (en) * 2013-08-09 2020-03-30 Glaxosmithkline Ip No 2 Ltd Tricyclic benzoxaborole compounds and uses thereof

Also Published As

Publication number Publication date
PT3256479T (pt) 2020-10-22
SI3256479T1 (sl) 2020-11-30
CA2976030A1 (en) 2016-08-18
KR20170117158A (ko) 2017-10-20
CO2017008816A2 (es) 2017-11-10
MA41495A (fr) 2017-12-19
TWI730953B (zh) 2021-06-21
WO2016128949A1 (en) 2016-08-18
UA120527C2 (uk) 2019-12-26
IL253865A0 (en) 2017-10-31
EP3256479B1 (en) 2020-07-29
CN107548398A (zh) 2018-01-05
HRP20201597T1 (hr) 2020-12-25
US20180044353A1 (en) 2018-02-15
JP2018506538A (ja) 2018-03-08
WO2016128948A1 (en) 2016-08-18
US20210053996A1 (en) 2021-02-25
CY1123687T1 (el) 2022-03-24
ZA201705456B (en) 2019-10-30
AU2016217508A1 (en) 2017-09-28
CN107531730B (zh) 2020-08-07
BR112017017211A2 (pt) 2018-04-03
EP3256479A1 (en) 2017-12-20
AU2016217507B2 (en) 2019-03-14
NZ734379A (en) 2023-06-30
MA41494A (fr) 2017-12-19
HUE051113T2 (hu) 2021-01-28
TW201643173A (zh) 2016-12-16
PE20171348A1 (es) 2017-09-13
SG11201706510YA (en) 2017-09-28
EA201791667A1 (ru) 2018-02-28
AU2020256369A1 (en) 2020-11-12
RS60885B1 (sr) 2020-11-30
ES2821951T3 (es) 2021-04-28
CL2017002060A1 (es) 2018-03-16
IL253864A0 (en) 2017-09-28
US10774096B2 (en) 2020-09-15
EA201791671A1 (ru) 2018-02-28
CR20170372A (es) 2017-10-19
PH12017501427A1 (en) 2018-01-15
CL2017002059A1 (es) 2018-03-16
PL3256479T3 (pl) 2021-06-14
AU2016217507A1 (en) 2017-09-28
CO2017008809A2 (es) 2017-11-10
MX379057B (es) 2025-03-10
SMT202000565T1 (it) 2020-11-10
US11214582B2 (en) 2022-01-04
JP6771472B2 (ja) 2020-10-21
SG11201706511TA (en) 2017-09-28
CA2976030C (en) 2023-09-26
EA036516B1 (ru) 2020-11-18
CN107531730A (zh) 2018-01-02
PH12017501428A1 (en) 2018-01-15
PE20171432A1 (es) 2017-09-26
LT3256479T (lt) 2020-12-28
DK3256479T3 (da) 2020-11-02
KR20170117156A (ko) 2017-10-20
EP3256480A1 (en) 2017-12-20
BR112017017211B1 (pt) 2023-04-25
IL253864B (en) 2021-07-29
DOP2017000188A (es) 2017-09-15
BR112017017213A2 (pt) 2018-04-03
TW201702250A (zh) 2017-01-16
MX2017010413A (es) 2018-05-11
US20180037595A1 (en) 2018-02-08
CR20170371A (es) 2018-01-22
MA41494B1 (fr) 2020-10-28
MY194004A (en) 2022-11-07
JP2018506540A (ja) 2018-03-08
MX2017010414A (es) 2018-05-11
CA2976308A1 (en) 2016-08-18

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