[go: up one dir, main page]

DOP2016000285A - Procedimiento para la preparación de 4-­{4-­[({[4-­cloro-­3-­(trifluorometil)fenil]amino}carbonil)amino]-­3-­fluorofenoxi}-­n-­metilpiridina-­2-­carboxamida, sus sales y su monohidrato - Google Patents

Procedimiento para la preparación de 4-­{4-­[({[4-­cloro-­3-­(trifluorometil)fenil]amino}carbonil)amino]-­3-­fluorofenoxi}-­n-­metilpiridina-­2-­carboxamida, sus sales y su monohidrato

Info

Publication number
DOP2016000285A
DOP2016000285A DO2016000285A DO2016000285A DOP2016000285A DO P2016000285 A DOP2016000285 A DO P2016000285A DO 2016000285 A DO2016000285 A DO 2016000285A DO 2016000285 A DO2016000285 A DO 2016000285A DO P2016000285 A DOP2016000285 A DO P2016000285A
Authority
DO
Dominican Republic
Prior art keywords
amino
carboxamide
phenyl
salts
preparation
Prior art date
Application number
DO2016000285A
Other languages
English (en)
Inventor
Juergen Stiehl
Joachim Rehse
Michael Gottfried
Saskia Wichmann
Werner Heilmann
Michael Lögers
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44070712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2016000285(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of DOP2016000285A publication Critical patent/DOP2016000285A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación de 4-­{4-­[({[4-­cloro-­3-(trifluorometil)fenil]amino}carbonil)amino]-­3-­fluorofenoxi}-­N-­metilpiridina-­2-­carboxamida, sus sales y su monohidrato.
DO2016000285A 2010-04-15 2016-10-20 Procedimiento para la preparación de 4-­{4-­[({[4-­cloro-­3-­(trifluorometil)fenil]amino}carbonil)amino]-­3-­fluorofenoxi}-­n-­metilpiridina-­2-­carboxamida, sus sales y su monohidrato DOP2016000285A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10004022 2010-04-15

Publications (1)

Publication Number Publication Date
DOP2016000285A true DOP2016000285A (es) 2016-11-30

Family

ID=44070712

Family Applications (2)

Application Number Title Priority Date Filing Date
DO2012000268A DOP2012000268A (es) 2010-04-15 2012-10-12 Procedimiento para la preparacion de 4-{4-[({[4-cloro-3-(trifluorometil) fenil]animo}carbonil)amino]-3-fluorofenoxi}-n-metilpiridina-2-carboxamida, sus sales y su monohidrato
DO2016000285A DOP2016000285A (es) 2010-04-15 2016-10-20 Procedimiento para la preparación de 4-­{4-­[({[4-­cloro-­3-­(trifluorometil)fenil]amino}carbonil)amino]-­3-­fluorofenoxi}-­n-­metilpiridina-­2-­carboxamida, sus sales y su monohidrato

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DO2012000268A DOP2012000268A (es) 2010-04-15 2012-10-12 Procedimiento para la preparacion de 4-{4-[({[4-cloro-3-(trifluorometil) fenil]animo}carbonil)amino]-3-fluorofenoxi}-n-metilpiridina-2-carboxamida, sus sales y su monohidrato

Country Status (40)

Country Link
US (5) US8748622B2 (es)
EP (1) EP2558448B1 (es)
JP (1) JP5934182B2 (es)
KR (2) KR101800041B1 (es)
CN (2) CN103980191A (es)
AR (2) AR081060A1 (es)
AU (1) AU2011240113B2 (es)
BR (1) BR112012026117B1 (es)
CA (1) CA2796238C (es)
CL (1) CL2012002840A1 (es)
CO (1) CO6630136A2 (es)
CR (1) CR20120526A (es)
CU (2) CU24123B1 (es)
DK (1) DK2558448T3 (es)
DO (2) DOP2012000268A (es)
EC (1) ECSP12012234A (es)
ES (1) ES2542610T3 (es)
GT (1) GT201200280A (es)
HK (1) HK1200831A1 (es)
HR (1) HRP20150885T1 (es)
HU (1) HUE026821T2 (es)
IL (2) IL222348B (es)
JO (1) JO3158B1 (es)
MA (1) MA34156B1 (es)
MX (1) MX2012011734A (es)
MY (2) MY162359A (es)
NZ (1) NZ602997A (es)
PE (2) PE20130181A1 (es)
PH (1) PH12012502060A1 (es)
PL (1) PL2558448T3 (es)
PT (1) PT2558448E (es)
RS (1) RS54219B1 (es)
RU (1) RU2581585C2 (es)
SG (2) SG184172A1 (es)
SI (1) SI2558448T1 (es)
TN (1) TN2012000492A1 (es)
TW (2) TWI539951B (es)
UA (1) UA110613C2 (es)
UY (2) UY33290A (es)
WO (1) WO2011128261A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2581843C (en) * 2004-09-29 2012-05-15 Bayer Healthcare Ag Thermodynamically stable form of bay 43-9006 tosylate
ES2351612T3 (es) 2005-03-07 2011-02-08 Bayer Schering Pharma Aktiengesellschaft Composición farmacéutica que comprende una difenilurea sustituida con omega-carboxiarilo para el tratamiento del cáncer.
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
JO3479B1 (ar) * 2012-09-06 2020-07-05 Bayer Healthcare Llc تركيبة دوائية مغلفة تحتوي على ريجورافنيب
HK1214169A1 (zh) 2012-09-25 2016-07-22 Bayer Pharma Aktiengesellschaft 用於治疗癌症的瑞戈非尼和乙酰水杨酸的组合
CN104250227A (zh) * 2013-06-29 2014-12-31 广东东阳光药业有限公司 瑞戈非尼新晶型及其制备方法
IN2013CH04511A (es) * 2013-10-04 2015-04-10 Hetero Research Foundation
CN105218439B (zh) * 2014-06-06 2018-11-20 连云港润众制药有限公司 一种瑞格非尼的晶体及其制备方法
WO2016005874A1 (en) * 2014-07-09 2016-01-14 Shilpa Medicare Limited Process for the preparation of regorafenib and its crystalline forms
CN104557689B (zh) * 2015-01-26 2016-06-29 重庆两江药物研发中心有限公司 制备4-[4-({[4-氯-3-(三氟甲基)苯基]氨基甲酰}氨基)-3-氟苯氧基]-n-甲基吡啶-2-甲酰胺及其一水合物的方法
CN104592105B (zh) * 2015-02-10 2017-01-18 杭州朱养心药业有限公司 瑞戈非尼及其制法
CN105330600B (zh) * 2015-11-30 2018-05-22 山东罗欣药业集团股份有限公司 一种瑞戈菲尼的制备方法
AU2016387566A1 (en) * 2016-01-18 2018-08-09 Natco Pharma Ltd An improved process for the preparation of Regorafenib
CN107118153A (zh) * 2016-02-25 2017-09-01 石药集团中奇制药技术（石家庄）有限公司 一种瑞戈非尼一水合物晶型及其制备方法
CN105879049B (zh) * 2016-05-13 2019-03-26 浙江大学 一种瑞戈非尼与β-环糊精的包合物及其制备方法
FI3630112T3 (fi) 2017-06-02 2024-05-02 Bayer Healthcare Llc Regorafenibin ja nivolumabin yhdistelmä syövän hoidossa
CN109438336B (zh) * 2018-11-27 2019-11-22 广东安诺药业股份有限公司 一种瑞戈非尼水合物的制备方法
CN109438337B (zh) * 2018-11-27 2019-08-09 广东安诺药业股份有限公司 一种瑞戈非尼中间体的制备工艺
EP3861989A1 (en) 2020-02-07 2021-08-11 Bayer Aktiengesellschaft Pharmaceutical composition containing regorafenib and a stabilizing agent
WO2021160708A1 (en) 2020-02-14 2021-08-19 Bayer Aktiengesellschaft Combination of regorafenib and msln-ttc for treating cancer
CN114315710B (zh) * 2022-01-07 2024-04-26 江苏豪森药业集团有限公司 一种制备或纯化瑞戈非尼的方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187799B1 (en) 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20080269265A1 (en) 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
RU2319693C9 (ru) 1999-01-13 2008-08-20 Байер Копэрейшн Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты)
JP2002534468A (ja) 1999-01-13 2002-10-15 バイエル コーポレイション ｐ３８キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
DE60216139T3 (de) 2001-12-03 2018-11-15 Bayer Healthcare Llc Arylharnstoff-verbindungen in kombination mit anderen zytostatisch oder zytotoxisch wirksamen stoffen zur behandlungen menschlicher krebserkrankungen
US10653684B2 (en) 2002-02-11 2020-05-19 Bayer Healthcare Llc Aryl ureas with angiogenisis inhibiting activity
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
AU2003209119A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
MXPA04007830A (es) 2002-02-11 2005-07-01 Bayer Pharmaceuticals Corp Arilureas como inhibidores de cinasa.
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
ATE366108T1 (de) 2003-05-20 2007-07-15 Bayer Pharmaceuticals Corp Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten
MY142799A (en) 2003-07-23 2010-12-31 Bayer Healthcare Llc Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
ATE517885T1 (de) 2004-04-30 2011-08-15 Bayer Healthcare Llc Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs
MY191349A (en) 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
MX2007002398A (es) 2004-08-27 2007-05-15 Bayer Pharmaceuticals Corp Nuevas composiciones farmaceuticas para el tratamiento de cancer.
JP2008514657A (ja) 2004-09-29 2008-05-08 バイエル・ヘルスケア・アクチェンゲゼルシャフト ４−｛４−［（｛［４−クロロ−３−（トリフルオロメチル）フェニル］アミノ｝カルボニル）アミノ］フェノキシ｝−ｎ−メチルピリジン−２−カルボキサミドの製造方法
CA2581843C (en) 2004-09-29 2012-05-15 Bayer Healthcare Ag Thermodynamically stable form of bay 43-9006 tosylate
ES2351612T3 (es) 2005-03-07 2011-02-08 Bayer Schering Pharma Aktiengesellschaft Composición farmacéutica que comprende una difenilurea sustituida con omega-carboxiarilo para el tratamiento del cáncer.
US20090215835A1 (en) 2005-10-31 2009-08-27 Scott Wilhelm Treatment of cancer with sorafenib
WO2007059154A2 (en) 2005-11-14 2007-05-24 Bayer Healthcare Llc Treatment of cancers with acquired resistance to kit inhibitors
AR062927A1 (es) * 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
JP2010509253A (ja) * 2006-11-09 2010-03-25 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト ４−［４−（｛［４−クロロ−３−（トリフルオロメチル）フェニル］カルバモイル｝アミノ）−３−フルオロフェノキシ］−ｎ−メチルピリジン−２−カルボキサミドの多形ｉｉｉ
US20100113533A1 (en) * 2006-11-14 2010-05-06 Bayer Schering Pharma Aktiengesellschaft Polymorph II of 4-[4-(Amino)-3- Fluorophenoxy]-N-Methylpyridine-2-Carboxamide
WO2008079968A1 (en) 2006-12-20 2008-07-03 Bayer Healthcare Llc 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl) phenyl]-1h-pyrazol-5-yl } carbamoyl)-amino] -3-fluorophenoxy} -n-methylpyridine-2-carboxamide as well as prodrugs and salts thereof for the treatment of cancer
EP2129376B1 (en) 2007-01-19 2013-07-24 Bayer HealthCare LLC Treatment of cancers with acquired resistance to KIT inhibitors
US20100173954A1 (en) 2007-01-19 2010-07-08 Bayer Healthcare Llc Treatment of cancers having resistance to chemotherapeutic agents
EP2156834A1 (en) * 2008-08-08 2010-02-24 S.I.F.I - Società Industria Farmaceutica Italiana - S.P.A. Ophthalmic pharmaceutical compositions comprising Sorafenib for the treatment of neoangiogenic pathologies of the eye
JP5439494B2 (ja) 2008-10-21 2014-03-12 バイエル ヘルスケア エルエルシー 肝細胞癌と関連するシグネチャ遺伝子の同定
RU2011150619A (ru) 2009-05-15 2013-06-20 Новартис Аг Комбинация ингибитора фосфоинозитид-3-киназы и противодиабетического соединения
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
JP2013531067A (ja) 2010-07-19 2013-08-01 バイエル ヘルスケア リミティド ライアビリティ カンパニー 疾病及び状態の処置及び予防のためのフルオロ置換オメガ−カルボキシアリールジフェニル尿素を用いた組み合わせ薬
MX2013003695A (es) 2010-10-01 2013-05-20 Bayer Ip Gmbh Combinaciones que contienen n-(2-arilamino) arilsulfonamida sustituida.
US20140235678A1 (en) 2011-06-28 2014-08-21 Bayer Healthcare Llc Topical Ophthalmological Pharmaceutical Composition containing Sorafenib
JP5998213B2 (ja) 2011-06-28 2016-09-28 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ レゴラフェニブを含有する眼科用局所医薬組成物
US8841500B2 (en) 2011-11-08 2014-09-23 Chevron U.S.A. Inc. Preparation of alkyl aromatic compounds
JP2014032346A (ja) 2012-08-06 2014-02-20 Japan Display Inc 液晶表示パネル
JO3479B1 (ar) 2012-09-06 2020-07-05 Bayer Healthcare Llc تركيبة دوائية مغلفة تحتوي على ريجورافنيب

Also Published As

Publication number Publication date
CA2796238C (en) 2019-12-31
TWI475992B (zh) 2015-03-11
UY33290A (es) 2011-12-01
RS54219B1 (en) 2015-12-31
AR081060A1 (es) 2012-06-06
TW201509415A (zh) 2015-03-16
CN102947271B (zh) 2016-11-09
US20130116442A1 (en) 2013-05-09
RU2581585C2 (ru) 2016-04-20
KR20170129276A (ko) 2017-11-24
TW201204356A (en) 2012-02-01
AR116395A2 (es) 2021-05-05
RU2012148386A (ru) 2014-05-20
PE20160838A1 (es) 2016-09-24
US20190144391A1 (en) 2019-05-16
BR112012026117A2 (pt) 2015-09-08
US20170057918A1 (en) 2017-03-02
SG10201501221UA (en) 2015-04-29
US10822305B2 (en) 2020-11-03
IL222348A0 (en) 2012-12-31
ECSP12012234A (es) 2012-11-30
GT201200280A (es) 2014-07-23
SI2558448T1 (sl) 2015-11-30
IL253119A0 (en) 2017-08-31
MX2012011734A (es) 2012-12-17
BR112012026117B1 (pt) 2022-08-30
MA34156B1 (fr) 2013-04-03
DOP2012000268A (es) 2012-12-15
US20140221661A1 (en) 2014-08-07
JO3158B1 (ar) 2017-09-20
PE20130181A1 (es) 2013-02-23
WO2011128261A1 (en) 2011-10-20
IL253119B (en) 2018-03-29
PT2558448E (pt) 2015-09-01
DK2558448T3 (en) 2015-08-24
CU24123B1 (es) 2015-08-27
CU20140060A7 (es) 2014-10-02
US9458107B2 (en) 2016-10-04
UY39590A (es) 2022-01-31
PL2558448T3 (pl) 2015-10-30
KR101800041B1 (ko) 2017-11-21
AU2011240113A1 (en) 2012-10-11
TWI539951B (zh) 2016-07-01
EP2558448B1 (en) 2015-05-20
HRP20150885T1 (hr) 2015-10-09
MY162359A (en) 2017-06-15
JP5934182B2 (ja) 2016-06-15
SG184172A1 (en) 2012-11-29
CN102947271A (zh) 2013-02-27
EP2558448A1 (en) 2013-02-20
NZ602997A (en) 2014-10-31
CO6630136A2 (es) 2013-03-01
AU2011240113B2 (en) 2014-12-18
KR20130061670A (ko) 2013-06-11
CU20120147A7 (es) 2013-01-30
TN2012000492A1 (en) 2014-04-01
CA2796238A1 (en) 2011-10-20
HK1200831A1 (en) 2015-08-14
PH12012502060A1 (en) 2013-02-04
BR112012026117A8 (pt) 2017-12-19
US8748622B2 (en) 2014-06-10
CN103980191A (zh) 2014-08-13
IL222348B (en) 2018-08-30
CL2012002840A1 (es) 2013-01-18
HUE026821T2 (en) 2016-07-28
MY177066A (en) 2020-09-03
ES2542610T3 (es) 2015-08-07
UA110613C2 (uk) 2016-01-25
US20170334857A1 (en) 2017-11-23
CR20120526A (es) 2013-03-11
JP2013523851A (ja) 2013-06-17

Similar Documents

Publication Publication Date Title
DOP2016000285A (es) Procedimiento para la preparación de 4-­{4-­[({[4-­cloro-­3-­(trifluorometil)fenil]amino}carbonil)amino]-­3-­fluorofenoxi}-­n-­metilpiridina-­2-­carboxamida, sus sales y su monohidrato
BR112013020611A2 (pt) método para produção de compostos quelato de aminoácido, compostos quelato de aminoácido e uso de compostos quelato de aminoácido
UA111333C2 (uk) Спосіб одержання l-аргінінової солі периндроприлу
WO2013150545A8 (en) Process for preparation of benzimidazole derivatives and salts thereof
HK1205095A1 (en) Methods and intermediates for preparing pharmaceutical agents
EA201200498A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201200123A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
UY34386A (es) Método para la producción de ácido láctico
EA201100230A1 (ru) Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой
UA111329C2 (uk) Спосіб синтезу івабрадину і його адитивних солей з фармацевтично прийнятною кислотою
UA118008C2 (uk) Спосіб синтезу (2е)-3-(3,4-диметоксифеніл)проп-2-еннітрилу та застосування в синтезі івабрадину та його адитивних солей з фармацевтично прийнятною кислотою
EA201301235A1 (ru) Новый способ синтеза 3-(2-бром-4,5-диметоксифенил)пропаннитрила и применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
UA111156C2 (uk) Спосіб синтезу івабрадину і його адитивних солей з фармацевтично прийнятною кислотою
EA201300281A2 (ru) Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой
EA201301020A1 (ru) Новый способ синтеза 3-(2-бром-4,5-диметоксифенил)пропаннитрила и применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
CY1116366T1 (el) Νεα μεθοδος για τη συνθεση αγομελατινης
UY34626A (es) Proceso para la preparación estereoselectiva de pirazol carboxamida y compuestos intermediarios