DOP2011000033A - PHARMACEUTICAL COMPOSITION - Google Patents
PHARMACEUTICAL COMPOSITIONInfo
- Publication number
- DOP2011000033A DOP2011000033A DO2011000033A DO2011000033A DOP2011000033A DO P2011000033 A DOP2011000033 A DO P2011000033A DO 2011000033 A DO2011000033 A DO 2011000033A DO 2011000033 A DO2011000033 A DO 2011000033A DO P2011000033 A DOP2011000033 A DO P2011000033A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- pharmaceutical composition
- active ingredient
- pharmaceutically active
- stabilized
- solid preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención provee una composición farmacéutica o una preparación sólida qiie contiene un ingrediente farmacéuticainente activo estabilizado y un método para &stabilizar la misma. De acuerdo con la presente invención, una composición farinacéutica puede estabilizarse al contener un ingrediente farmacéuticamente activo no peptídico que tiene un grupo amino primario o secundario, un excipiente y un compuesto acídico. Además, una preparación sólida que contiene un ingrediente farmacéuticamente activo, óxido de titanio, un plastificante y un ácido orgánico de cadena puede aumentar la estabilidad del ingrediente farmacéuticamente activo durante una irradiación luminosa.The present invention provides a pharmaceutical composition or a solid preparation that contains a stabilized active pharmaceutical ingredient and a method for & stabilizing it. In accordance with the present invention, a pharmaceutical composition may be stabilized by containing a non-peptide pharmaceutically active ingredient having a primary or secondary amino group, an excipient and an acidic compound. In addition, a solid preparation containing a pharmaceutically active ingredient, titanium oxide, a plasticizer and an organic chain acid can increase the stability of the pharmaceutically active ingredient during light irradiation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008194219 | 2008-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2011000033A true DOP2011000033A (en) | 2011-04-15 |
Family
ID=41327301
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2011000033A DOP2011000033A (en) | 2008-07-28 | 2011-01-28 | PHARMACEUTICAL COMPOSITION |
| DO2013000172A DOP2013000172A (en) | 2008-07-28 | 2013-07-31 | PHARMACEUTICAL COMPOSITION |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2013000172A DOP2013000172A (en) | 2008-07-28 | 2013-07-31 | PHARMACEUTICAL COMPOSITION |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US9186411B2 (en) |
| EP (2) | EP2309985B1 (en) |
| JP (2) | JP5295356B2 (en) |
| KR (1) | KR20110042334A (en) |
| CN (3) | CN102164581A (en) |
| AR (1) | AR072842A1 (en) |
| AU (1) | AU2009277443A1 (en) |
| BR (1) | BRPI0916689A2 (en) |
| CA (2) | CA2936400C (en) |
| CL (1) | CL2011000170A1 (en) |
| CO (1) | CO6290638A2 (en) |
| CR (1) | CR20110110A (en) |
| DO (2) | DOP2011000033A (en) |
| EA (2) | EA201201451A1 (en) |
| EC (1) | ECSP11010855A (en) |
| ES (2) | ES2660962T3 (en) |
| GE (2) | GEP20146122B (en) |
| IL (2) | IL210735A0 (en) |
| MA (1) | MA32556B1 (en) |
| MX (1) | MX2011000757A (en) |
| MY (2) | MY169461A (en) |
| NZ (2) | NZ602592A (en) |
| PE (3) | PE20110591A1 (en) |
| SG (1) | SG186685A1 (en) |
| TW (2) | TW201431552A (en) |
| UA (1) | UA103332C2 (en) |
| UY (1) | UY32008A (en) |
| WO (1) | WO2010013823A2 (en) |
| ZA (1) | ZA201101198B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013122260A1 (en) | 2012-02-15 | 2013-08-22 | Takeda Pharmaceutical Company Limited | Tablet |
| BR112014031282A2 (en) * | 2012-06-27 | 2017-06-27 | Takeda Pharmaceuticals Co | liquid preparation, methods of production of liquid preparation, stabilization of a liquid preparation, suppression of production of a reaction product of a pharmaceutically active ingredient, freeze-dried preparation, injection kit, use of a salt, and, salt |
| ES2622585T3 (en) | 2012-09-19 | 2017-07-06 | Taiho Pharmaceutical Co., Ltd. | Pharmaceutical composition for oral administration with improved elution and / or absorbency |
| EP3632482A1 (en) * | 2013-03-14 | 2020-04-08 | Allergan, Inc. | Polymer system for securing implants in syringe needles |
| CN105330647A (en) * | 2014-08-14 | 2016-02-17 | 江苏柯菲平医药股份有限公司 | Pyrrole sulfonamide derivative, preparation method and medical application thereof |
| CN105985278A (en) * | 2015-01-27 | 2016-10-05 | 江苏柯菲平医药股份有限公司 | Pyrrole sulfonyl derivatives, preparation method and medicinal application thereof |
| MA41850A (en) | 2015-03-31 | 2018-02-06 | Takeda Pharmaceuticals Co | NEW PHARMACEUTICAL USES |
| MY189306A (en) | 2015-07-30 | 2022-02-03 | Takeda Pharmaceuticals Co | Tablet |
| CN105106203B (en) * | 2015-08-17 | 2019-04-05 | 江苏豪森药业集团有限公司 | Pharmaceutical composition of Vonoprazan fumarate and preparation method thereof |
| CN105030720B (en) * | 2015-08-26 | 2019-12-10 | 迪沙药业集团有限公司 | vonoprazan fumarate enteric-coated tablet and preparation method thereof |
| CN105030725B (en) * | 2015-08-26 | 2019-12-10 | 迪沙药业集团有限公司 | Vonoprazan fumarate enteric-coated composition and preparation method thereof |
| CN107224438B (en) * | 2016-03-25 | 2021-04-06 | 江苏豪森药业集团有限公司 | Vonoprazan fumarate pharmaceutical composition |
| CN110072518B (en) * | 2016-10-12 | 2021-10-26 | 细胞内治疗公司 | Amorphous solid dispersion |
| CN106580903B (en) * | 2016-11-17 | 2019-12-13 | 江苏豪森药业集团有限公司 | Roxithromycin sustained-release pharmaceutical composition |
| CN106860852A (en) * | 2017-02-17 | 2017-06-20 | 王清华 | A kind of mucus Western medicine for combined treatment stomach trouble |
| CA3060536A1 (en) | 2017-05-31 | 2018-12-06 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and pharmaceutical dosage form comprising (e)-4-(2-(aminomethyl)-3-fluoroallyloxy)-n-tert-butylbenzamide, process for their preparation, methods for treating and uses thereof |
| WO2019013310A1 (en) * | 2017-07-10 | 2019-01-17 | Takeda Pharmaceutical Company Limited | Preparation comprising vonoprazan |
| CN108558831B (en) * | 2018-06-08 | 2021-07-27 | 上海璃道医药科技有限公司 | Substituted pyrrole-4-alkylamine compound and application thereof |
| KR102126576B1 (en) | 2018-09-19 | 2020-06-24 | 주식회사 대웅제약 | Manufacturing method for 4-methoxypyrrole derivatives |
| CN109288722B (en) * | 2018-11-09 | 2021-03-30 | 伯德创研(广州)生物科技有限公司 | A kind of foundation for color changing and correcting skin tone and preparation method thereof |
| CN110538153B (en) * | 2019-09-26 | 2022-04-26 | 扬子江药业集团四川海蓉药业有限公司 | High-stability and quick-release solid preparation and preparation method thereof |
| CN111973565A (en) * | 2020-07-07 | 2020-11-24 | 南京海纳医药科技股份有限公司 | Vonoprazan fumarate-containing tablet and dissolution rate determination method thereof |
| CN114053239A (en) * | 2020-08-01 | 2022-02-18 | 吉林汇康制药有限公司 | Voranolasheng fumarate pharmaceutical composition and preparation method thereof |
| CN111943932B (en) * | 2020-08-06 | 2023-07-14 | 四川国康药业有限公司 | 3-pyridine sulfonyl-1-N-hetero pyrrole derivative capable of treating peptic ulcer and preparation method and application thereof |
| CN114853728B (en) * | 2022-05-07 | 2023-11-07 | 四川制药制剂有限公司 | Vonopraz fumarate tablet and preparation method thereof |
| CN115364065B (en) * | 2022-08-23 | 2024-03-15 | 宁波高新区美诺华医药创新研究院有限公司 | Furanolas fumarate green sheet |
| CN117462507B (en) * | 2023-12-28 | 2024-03-15 | 山东齐都药业有限公司 | Vonola fumarate crude drug composition and preparation method thereof |
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| US7247702B2 (en) * | 2002-02-28 | 2007-07-24 | The Penn State Research Foundation | Periocular drug delivery for diabetic retinopathy |
| RS52088B (en) | 2002-03-07 | 2012-06-30 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Form of presentation for 3-/(2-(/4-(hexyloxycarbonylamino- imino-methyl)-phenylamino/-methyl)-1-methyl-1h-benzimidazol -5-carbonyl)pyridin-2-yl-amino/propionic acid ethyl ester to be administered orally |
| US6818662B2 (en) | 2002-05-28 | 2004-11-16 | Taisho Pharmaceutical Co., Ltd. | Pharmaceutical composition |
| DE10233108A1 (en) * | 2002-07-20 | 2004-01-29 | Krewel Meuselbach Gmbh | Delayed pain reliever containing tilidine and a light stabilizer |
| AU2003301121A1 (en) * | 2002-12-18 | 2004-07-14 | Pain Therapeutics, Inc. | Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats |
| TW200503783A (en) | 2003-04-11 | 2005-02-01 | Altana Pharma Ag | Oral pharmaceutical preparation for proton pump antagonists |
| US20050037070A1 (en) | 2003-07-18 | 2005-02-17 | Santarus, Inc. | Pharmaceutical formulatins useful for inhibiting acid secretion and methods for making and using them |
| DE10337697A1 (en) * | 2003-08-16 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tablet containing 3 - [(2 - {[4- (hexyloxycarbonylamino-iminomethyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] - propionic acid ethyl ester or its salts |
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-
2009
- 2009-07-27 UY UY32008A patent/UY32008A/en not_active Application Discontinuation
- 2009-07-27 CA CA2936400A patent/CA2936400C/en active Active
- 2009-07-27 MX MX2011000757A patent/MX2011000757A/en not_active Application Discontinuation
- 2009-07-27 EA EA201201451A patent/EA201201451A1/en unknown
- 2009-07-27 EP EP09788013.2A patent/EP2309985B1/en active Active
- 2009-07-27 PE PE2011000089A patent/PE20110591A1/en not_active Application Discontinuation
- 2009-07-27 WO PCT/JP2009/063708 patent/WO2010013823A2/en active Application Filing
- 2009-07-27 JP JP2011504079A patent/JP5295356B2/en active Active
- 2009-07-27 ES ES12194777.4T patent/ES2660962T3/en active Active
- 2009-07-27 UA UAA201102390A patent/UA103332C2/en unknown
- 2009-07-27 MY MYPI2014000760A patent/MY169461A/en unknown
- 2009-07-27 TW TW103115778A patent/TW201431552A/en unknown
- 2009-07-27 ES ES09788013.2T patent/ES2669592T3/en active Active
- 2009-07-27 GE GEAP200912530A patent/GEP20146122B/en unknown
- 2009-07-27 EA EA201170272A patent/EA201170272A1/en unknown
- 2009-07-27 NZ NZ60259209A patent/NZ602592A/en not_active IP Right Cessation
- 2009-07-27 BR BRPI0916689A patent/BRPI0916689A2/en not_active IP Right Cessation
- 2009-07-27 MY MYPI2011000398A patent/MY156305A/en unknown
- 2009-07-27 CA CA2732243A patent/CA2732243C/en active Active
- 2009-07-27 CN CN2009801376029A patent/CN102164581A/en active Pending
- 2009-07-27 AU AU2009277443A patent/AU2009277443A1/en not_active Abandoned
- 2009-07-27 SG SG2012095162A patent/SG186685A1/en unknown
- 2009-07-27 NZ NZ59134409A patent/NZ591344A/en not_active IP Right Cessation
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- 2009-07-27 EP EP12194777.4A patent/EP2564833B1/en active Active
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