DOP2009000041A - N-ALQUIL-NALTREXONA HALOGENURE PREPARATION PROCEDURE - Google Patents
N-ALQUIL-NALTREXONA HALOGENURE PREPARATION PROCEDUREInfo
- Publication number
- DOP2009000041A DOP2009000041A DO2009000041A DO2009000041A DOP2009000041A DO P2009000041 A DOP2009000041 A DO P2009000041A DO 2009000041 A DO2009000041 A DO 2009000041A DO 2009000041 A DO2009000041 A DO 2009000041A DO P2009000041 A DOP2009000041 A DO P2009000041A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- carbonate
- methyl
- naltrexone
- naltrexona
- halogenure
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 239000012431 aqueous reaction media Substances 0.000 abstract 2
- JVLBPIPGETUEET-GAAHOAFPSA-O methylnaltrexone Chemical compound C[N+]1([C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)CC1CC1 JVLBPIPGETUEET-GAAHOAFPSA-O 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- IFGIYSGOEZJNBE-KNLJMPJLSA-N (4r,4as,7ar,12bs)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one;bromide Chemical compound [Br-].C[N+]1([C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)CC1CC1 IFGIYSGOEZJNBE-KNLJMPJLSA-N 0.000 abstract 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 abstract 1
- 229910000024 caesium carbonate Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- BDAGIHXWWSANSR-NJFSPNSNSA-N hydroxyformaldehyde Chemical compound O[14CH]=O BDAGIHXWWSANSR-NJFSPNSNSA-N 0.000 abstract 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 abstract 1
- 239000001095 magnesium carbonate Substances 0.000 abstract 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 abstract 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 229910000018 strontium carbonate Inorganic materials 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a un nuevo procedimiento de preparación del bromuro de N-metil-naltrexona, que comprende al menos las etapas que consinten enÑ (i) hacer reaccionar el metilsulfato de n-metil-naltrexona en soluución acuosa con un agente alcalino elegido del grupo constituido por carbonato de sodio, carbonato de potasio y carbonato de clacio, carbonato de magnesio, carbonato de cesio, carbonato de estroncio y las mezclas de estos, para un pH del medio de reacción acuoso comprendido entre 7 y 10, y después (ii) hacer reaccionar el producto obtenido en el ácido bromhídrico quese añade, para un pH del medio de reacción acuoso comprendido ente 0.5 y 5 y obtener aí el bomuro de n-metil-naltrexona.The invention relates to a new process for the preparation of N-methyl-naltrexone bromide, which comprises at least the steps which involve enÑ (i) reacting the n-methyl-naltrexone methyl sulfate in aqueous solution with an alkaline agent chosen from the group consisting of sodium carbonate, potassium carbonate and clacio carbonate, magnesium carbonate, cesium carbonate, strontium carbonate and mixtures thereof, for a pH of the aqueous reaction medium between 7 and 10, and then (ii ) to react the product obtained in the hydrobromic acid that is added, for a pH of the aqueous reaction medium comprised between 0.5 and 5 and to obtain the n-methyl-naltrexone bomb.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2009000041A DOP2009000041A (en) | 2009-03-12 | 2009-03-12 | N-ALQUIL-NALTREXONA HALOGENURE PREPARATION PROCEDURE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DO2009000041A DOP2009000041A (en) | 2009-03-12 | 2009-03-12 | N-ALQUIL-NALTREXONA HALOGENURE PREPARATION PROCEDURE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2009000041A true DOP2009000041A (en) | 2009-05-15 |
Family
ID=44261550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2009000041A DOP2009000041A (en) | 2009-03-12 | 2009-03-12 | N-ALQUIL-NALTREXONA HALOGENURE PREPARATION PROCEDURE |
Country Status (1)
| Country | Link |
|---|---|
| DO (1) | DOP2009000041A (en) |
-
2009
- 2009-03-12 DO DO2009000041A patent/DOP2009000041A/en unknown
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