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DK92188A - PROCEDURE FOR PREPARING A COAGULATION-ACTIVE COMPLEX OF FACTOR VIII FRAGMENTS - Google Patents

PROCEDURE FOR PREPARING A COAGULATION-ACTIVE COMPLEX OF FACTOR VIII FRAGMENTS

Info

Publication number
DK92188A
DK92188A DK092188A DK92188A DK92188A DK 92188 A DK92188 A DK 92188A DK 092188 A DK092188 A DK 092188A DK 92188 A DK92188 A DK 92188A DK 92188 A DK92188 A DK 92188A
Authority
DK
Denmark
Prior art keywords
coagulation
fviii
complex
factor viii
preparing
Prior art date
Application number
DK092188A
Other languages
Danish (da)
Other versions
DK92188D0 (en
DK163833B (en
DK163833C (en
Inventor
Ole Nordfang
Mirella Ezban Rasmussen
Original Assignee
Nordisk Gentofte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK1987/000080 external-priority patent/WO1988000210A1/en
Application filed by Nordisk Gentofte filed Critical Nordisk Gentofte
Priority to DK092188A priority Critical patent/DK163833C/en
Publication of DK92188D0 publication Critical patent/DK92188D0/en
Publication of DK92188A publication Critical patent/DK92188A/en
Publication of DK163833B publication Critical patent/DK163833B/en
Application granted granted Critical
Publication of DK163833C publication Critical patent/DK163833C/en

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A coagulation-active complex of factor VIII fragments is prepared by a coagulation-inactive FVIII heavy chain being brought to react with a coagulation-inactive FVIII light chain in the presence of a complex-forming agent. Thus, FVIII-HC and FVIII-LC are converted into a coagulation-active FVIII complex in the presence of divalent metal ions, such as Mn2+, Ca2+ or Co2+, or a component of the prothrombin complex or a substance which possesses reactivity towards compounds which contain the group -SH and/or -S-S. <IMAGE>
DK092188A 1986-06-24 1988-02-23 PROCEDURE FOR THE PREPARATION OF A COAGULATION-ACTIVE COMPLEX OF FACTOR VIII FRAGMENTS DK163833C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK092188A DK163833C (en) 1986-06-24 1988-02-23 PROCEDURE FOR THE PREPARATION OF A COAGULATION-ACTIVE COMPLEX OF FACTOR VIII FRAGMENTS

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK295786 1986-06-24
DK295786A DK295786A (en) 1986-06-24 1986-06-24 PROCEDURE FOR PREPARING A COAGULATION-ACTIVE COMPLEX OF FACTOR VIII FRAGMENTS
PCT/DK1987/000080 WO1988000210A1 (en) 1986-06-24 1987-06-24 A process for producing a coagulation active complex of factor viii fragments
DK8700080 1987-06-24
DK092188A DK163833C (en) 1986-06-24 1988-02-23 PROCEDURE FOR THE PREPARATION OF A COAGULATION-ACTIVE COMPLEX OF FACTOR VIII FRAGMENTS
DK92188 1988-02-23

Publications (4)

Publication Number Publication Date
DK92188D0 DK92188D0 (en) 1988-02-23
DK92188A true DK92188A (en) 1988-02-23
DK163833B DK163833B (en) 1992-04-06
DK163833C DK163833C (en) 1992-09-21

Family

ID=8117562

Family Applications (2)

Application Number Title Priority Date Filing Date
DK295786A DK295786A (en) 1986-06-24 1986-06-24 PROCEDURE FOR PREPARING A COAGULATION-ACTIVE COMPLEX OF FACTOR VIII FRAGMENTS
DK092188A DK163833C (en) 1986-06-24 1988-02-23 PROCEDURE FOR THE PREPARATION OF A COAGULATION-ACTIVE COMPLEX OF FACTOR VIII FRAGMENTS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK295786A DK295786A (en) 1986-06-24 1986-06-24 PROCEDURE FOR PREPARING A COAGULATION-ACTIVE COMPLEX OF FACTOR VIII FRAGMENTS

Country Status (4)

Country Link
JP (1) JP2677546B2 (en)
AT (1) ATE100825T1 (en)
DK (2) DK295786A (en)
FI (1) FI100107B (en)

Also Published As

Publication number Publication date
DK92188D0 (en) 1988-02-23
JP2677546B2 (en) 1997-11-17
FI880852A (en) 1988-02-23
ATE100825T1 (en) 1994-02-15
DK163833B (en) 1992-04-06
JPH09117281A (en) 1997-05-06
DK295786A (en) 1987-12-25
DK163833C (en) 1992-09-21
FI100107B (en) 1997-09-30
DK295786D0 (en) 1986-06-24
FI880852A0 (en) 1988-02-23

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Legal Events

Date Code Title Description
PSP Patent surrendered