DK81888A - Dibenzoxepinderivater - Google Patents
DibenzoxepinderivaterInfo
- Publication number
- DK81888A DK81888A DK081888A DK81888A DK81888A DK 81888 A DK81888 A DK 81888A DK 081888 A DK081888 A DK 081888A DK 81888 A DK81888 A DK 81888A DK 81888 A DK81888 A DK 81888A
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- fluorine
- methoxy
- ring
- hydroxyl
- Prior art date
Links
- APMCUORPNXHBQK-UHFFFAOYSA-N benzo[c][1]benzoxepine Chemical class O1C=C2C=CC=CC2=CC2=CC=CC=C12 APMCUORPNXHBQK-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 229910052731 fluorine Chemical group 0.000 abstract 8
- 239000011737 fluorine Chemical group 0.000 abstract 8
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 208000002381 Brain Hypoxia Diseases 0.000 abstract 1
- 208000018152 Cerebral disease Diseases 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002082 anti-convulsion Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003859 lipid peroxidation Effects 0.000 abstract 1
- -1 methoxy, hydroxyl Chemical group 0.000 abstract 1
- 210000001700 mitochondrial membrane Anatomy 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14226986 | 1986-06-17 | ||
| JP87503725A JPH0560831B1 (da) | 1986-06-17 | 1986-06-17 | |
| JP8700392 | 1987-06-17 | ||
| PCT/JP1987/000392 WO1987007894A1 (en) | 1986-06-17 | 1987-06-17 | DIBENZ[b,e]OXEPIN DERIVATIVE AND PHARMACEUTICAL CONTAINING THE SAME AS ACTIVE INGREDIENT |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK81888D0 DK81888D0 (da) | 1988-02-17 |
| DK81888A true DK81888A (da) | 1988-02-17 |
| DK166540B1 DK166540B1 (da) | 1993-06-07 |
Family
ID=15311425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK081888A DK166540B1 (da) | 1986-06-17 | 1988-02-17 | Dibenzoeb,eaaoxepinderivater, fremgangsmaader til fremstilling deraf, farmaceutiske praeparater indeholdende forbindelserne samt anvendelse af forbindelserne |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4889858A (da) |
| EP (1) | EP0269755B1 (da) |
| JP (1) | JPH0560831B1 (da) |
| KR (1) | KR880701235A (da) |
| AU (1) | AU597687B2 (da) |
| DE (1) | DE3788195T2 (da) |
| DK (1) | DK166540B1 (da) |
| MX (1) | MX9202766A (da) |
| WO (1) | WO1987007894A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2852659B2 (ja) * | 1988-03-03 | 1999-02-03 | 富山化学工業株式会社 | ピペラジン誘導体およびその塩 |
| DE3919255A1 (de) * | 1989-06-13 | 1990-12-20 | Bayer Ag | Dibenzo/1,5/dioxocin-5-one-derivate, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
| ZA914764B (en) * | 1990-06-22 | 1992-03-25 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene,piperidylidene and piperazine compounds,compositions and methods of use |
| AU2028892A (en) * | 1991-05-23 | 1992-12-30 | Schering Corporation | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use |
| EP0524784A1 (en) * | 1991-07-23 | 1993-01-27 | Schering Corporation | Benzopyrido piperidylidene compounds as PAF antagonists |
| HU214331B (hu) * | 1992-06-17 | 1998-03-02 | Gyógyszerkutató Intézet Kft. | Eljárás piperazin- és homopiperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| US7314674B2 (en) * | 2004-12-15 | 2008-01-01 | General Electric Company | Corrosion resistant coating composition, coated turbine component and method for coating same |
| US7601400B2 (en) * | 2005-03-10 | 2009-10-13 | General Electric Company | Liquid electrostatic coating composition comprising corrosion resistant metal particulates and method for using same |
| US7544396B2 (en) * | 2005-03-10 | 2009-06-09 | General Electric Company | Electrostatic coating composition comprising corrosion resistant metal particulates and method for using same |
| US7311940B2 (en) * | 2005-11-04 | 2007-12-25 | General Electric Company | Layered paint coating for turbine blade environmental protection |
| US7604867B2 (en) * | 2005-12-20 | 2009-10-20 | General Electric Company | Particulate corrosion resistant coating composition, coated turbine component and method for coating same |
| US7955694B2 (en) * | 2006-06-21 | 2011-06-07 | General Electric Company | Strain tolerant coating for environmental protection |
| US9988390B2 (en) | 2015-10-30 | 2018-06-05 | F. Hoffmann-La Roche Ag | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1450362A (fr) * | 1964-06-29 | 1966-06-24 | Soc Ind Fab Antibiotiques Sifa | Nouvelles (pipérazinyl-1 alcoyl)-10 phénothiazines substituées et leurs sels, et procédé de préparation |
| CH554362A (de) * | 1970-07-30 | 1974-09-30 | Spofa Vereinigte Pharma Werke | Verfahren zur herstellung von neuen estern tricyklischer piperazinoalkanole. |
| CH569013A5 (da) * | 1972-07-21 | 1975-11-14 | Hoffmann La Roche | |
| DE2704934A1 (de) * | 1976-02-17 | 1977-08-18 | Sandoz Ag | Organische verbindungen, ihre herstellung und verwendung |
| US4082850A (en) * | 1976-04-16 | 1978-04-04 | American Hoechst Corporation | Method of treating dermal inflammations |
| SE8500273D0 (sv) * | 1985-01-22 | 1985-01-22 | Leo Ab | Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder |
-
1986
- 1986-06-17 JP JP87503725A patent/JPH0560831B1/ja active Pending
-
1987
- 1987-06-17 US US07/180,104 patent/US4889858A/en not_active Expired - Fee Related
- 1987-06-17 EP EP87904092A patent/EP0269755B1/en not_active Expired - Lifetime
- 1987-06-17 AU AU75477/87A patent/AU597687B2/en not_active Ceased
- 1987-06-17 DE DE3788195T patent/DE3788195T2/de not_active Expired - Fee Related
- 1987-06-17 WO PCT/JP1987/000392 patent/WO1987007894A1/ja active IP Right Grant
- 1987-06-17 KR KR1019880700180A patent/KR880701235A/ko not_active Application Discontinuation
-
1988
- 1988-02-17 DK DK081888A patent/DK166540B1/da not_active IP Right Cessation
-
1992
- 1992-06-10 MX MX9202766A patent/MX9202766A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK81888D0 (da) | 1988-02-17 |
| JPH0560831B1 (da) | 1993-09-03 |
| EP0269755A1 (en) | 1988-06-08 |
| AU7547787A (en) | 1988-01-12 |
| MX9202766A (es) | 1992-06-30 |
| KR880701235A (ko) | 1988-07-26 |
| DE3788195T2 (de) | 1994-06-09 |
| DE3788195D1 (de) | 1993-12-23 |
| DK166540B1 (da) | 1993-06-07 |
| EP0269755B1 (en) | 1993-11-18 |
| WO1987007894A1 (en) | 1987-12-30 |
| EP0269755A4 (en) | 1990-04-17 |
| AU597687B2 (en) | 1990-06-07 |
| US4889858A (en) | 1989-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |