DK707788A - 2,5-diaryltetrahydrofuranforbindelse, praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse - Google Patents

2,5-diaryltetrahydrofuranforbindelse, praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse

Info

Publication number: DK707788A
Authority: DK; Denmark
Prior art keywords: connection; diaryltetrahydrofuran; preparing; procedure; compound
Prior art date: 1987-12-21

Application number

DK707788A

Other languages

English (en)

Other versions

DK707788D0 (da

Inventor

Tesfaye Biftu

Thomas W Doebber

San-Boa Hwang

Thomas R Beattie

Tsung-Ying Shen

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-12-20

Publication date

1989-08-16

1988-12-20 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1988-12-20 Publication of DK707788D0 publication Critical patent/DK707788D0/da

1989-08-16 Publication of DK707788A publication Critical patent/DK707788A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C07D307/08—Preparation of tetrahydrofuran
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK707788A 1987-12-21 1988-12-20 2,5-diaryltetrahydrofuranforbindelse, praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse DK707788A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13586287A	1987-12-21	1987-12-21

Publications (2)

Publication Number	Publication Date
DK707788D0 DK707788D0 (da)	1988-12-20
DK707788A true DK707788A (da)	1989-08-16

Family

ID=22470061

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK707788A DK707788A (da)	1987-12-21	1988-12-20	2,5-diaryltetrahydrofuranforbindelse, praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse

Country Status (8)

Country	Link
EP (1)	EP0322033A3 (da)
JP (1)	JPH01211576A (da)
KR (1)	KR890009906A (da)
AU (1)	AU622881B2 (da)
DK (1)	DK707788A (da)
NZ (1)	NZ227287A (da)
PT (1)	PT89269B (da)
ZA (1)	ZA889350B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8712694D0 (en) *	1987-05-29	1987-07-01	Scras	Tetrahydrofurans etc
US4996203A (en) *	1987-12-21	1991-02-26	Merck & Co., Inc.	2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US5011847A (en) *	1989-06-08	1991-04-30	Merck & Co., Inc.	2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US5001123A (en) *	1989-06-08	1991-03-19	Merck & Co., Inc.	2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US4977146A (en) *	1989-06-08	1990-12-11	Merck & Co., Inc.	2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US5099033A (en) *	1990-06-29	1992-03-24	Merck & Co., Inc.	Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as PAF antagonists
EP0465122A1 (en) *	1990-06-29	1992-01-08	Merck & Co. Inc.	Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as paf antagonists
US5639782A (en) *	1992-03-04	1997-06-17	Center For Innovative Technology	Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5358938A (en) *	1992-07-13	1994-10-25	Cytomed, Inc.	Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5434151A (en) *	1992-08-24	1995-07-18	Cytomed, Inc.	Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5648486A (en) *	1992-07-13	1997-07-15	Cytomed, Inc.	Compounds and methods for the treatment of inflammatory and immune disorders
US5463083A (en) *	1992-07-13	1995-10-31	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
EP0650485B1 (en)	1992-07-13	2000-10-11	Cytomed, Inc.	2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders
US5792776A (en) *	1994-06-27	1998-08-11	Cytomed, Inc.,	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) *	1995-05-25	1998-05-12	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) *	1995-05-31	1997-12-30	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
LT2605652T (lt)	2010-08-18	2018-03-12	Samumed, Llc	Diketonai ir hidroksiketonai kaip katenino signalinio kelio aktyvintojai
SG10201606032VA (en)	2013-02-22	2016-09-29	Samumed Llc	Gamma-Diketones As Wnt/Beta -Catenin Signaling Pathway Activators
KR102165385B1 (ko)	2014-08-20	2020-10-15	사뮤메드, 엘엘씨	피부 노화 및 주름의 치료 및 예방을 위한 감마-디케톤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3769350A (en) *	1968-12-09	1973-10-30	Hoffmann La Roche	Method for making 2,3-dimethyl-1,4-bis(3,4 - hydrocarbonyloxyphenyl) - 1,4-butanedione
US4539332A (en) *	1983-11-14	1985-09-03	Merck & Co., Inc.	2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
US4595693A (en) *	1984-06-04	1986-06-17	Merck & Co., Inc.	Method of use of 2,5-diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
NZ215866A (en) *	1985-04-22	1989-11-28	Merck & Co Inc	2,5-di(aryl/heterocyclyl) tetrahydro-furans and pharmaceutical compositions

1988
- 1988-12-12 NZ NZ227287A patent/NZ227287A/en unknown
- 1988-12-14 EP EP88202879A patent/EP0322033A3/en not_active Withdrawn
- 1988-12-14 ZA ZA889350A patent/ZA889350B/xx unknown
- 1988-12-20 DK DK707788A patent/DK707788A/da not_active Application Discontinuation
- 1988-12-20 AU AU27304/88A patent/AU622881B2/en not_active Ceased
- 1988-12-20 PT PT89269A patent/PT89269B/pt not_active IP Right Cessation
- 1988-12-20 KR KR1019880017017A patent/KR890009906A/ko not_active Application Discontinuation
- 1988-12-21 JP JP63320764A patent/JPH01211576A/ja active Pending

Also Published As

Publication number	Publication date
PT89269A (pt)	1989-12-29
EP0322033A2 (en)	1989-06-28
ZA889350B (en)	1989-08-30
AU622881B2 (en)	1992-04-30
NZ227287A (en)	1992-01-29
AU2730488A (en)	1989-06-22
PT89269B (pt)	1993-08-31
EP0322033A3 (en)	1990-08-22
JPH01211576A (ja)	1989-08-24
DK707788D0 (da)	1988-12-20
KR890009906A (ko)	1989-08-04

Publication	Publication Date	Title
DK113088D0 (da)	1988-03-02	Fremgangsmaade til fremstilling af en thiazepinforbindelse
DK437286D0 (da)	1986-09-12	2,5-diaryl-tetrahydrothiophenforbindelse og fremgangsmaade til fremstilling deraf
DK707788D0 (da)	1988-12-20	2,5-diaryltetrahydrofuranforbindelse, praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse
DK181586D0 (da)	1986-04-21	2,5-diaryltetrahydrofuran, farmaceutisk praeparat indeholdende en saadanforbindelse og fremgangsmaade til fremstilling af en saadan forbindelse
DK313086A (da)	1987-01-03	Phenoxyalkylisoxazol- eller -furanforbindelse og fremgangsmaade til fremstilling deraf
DK188789A (da)	1989-10-23	N-alkoxy-alkylamidoforbindelse, praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse
DK4189A (da)	1989-07-09	Oxadiazolforbindelse, farmaceutisk praeparat indeholdende og fremgangsmaade til fremstilling af forbindelsen
DK220986D0 (da)	1986-05-13	Fremgangsmaade til fremstilling af piperidyliden-dihydrodibenzo(a,d)cycloheptener og aza-derivater deraf, forbindelser vundet ved fremgangsmaaden og disses anvendelse til fremstilling af farmaceutiske kompositioner
DK32788D0 (da)	1988-01-25	Fremgangsmaade til fremstilling af en drik
DK91885A (da)	1985-08-30	2,5-diaryltetrahydrothiophen, fremgangsmaade til fremstilling deraf og praeparat indeholdende en saadan forbindelse
NO864263L (no)	1987-04-27	1,2,4-triazol-3-karboksamidforbindelse, en fremgangsmaate for fremstilling derav og et herbicidpreparat inneholdende forbindelsen.
DK161788D0 (da)	1988-03-24	Fremgangsmaade til fremstilling af zidovudin
DK166088C (da)	1993-08-23	2'-deoxy-5-fluoruridinderivater, fremgangsmaade til fremstilling deraf, anticancermidler indeholdende saadanne forbindelser og anvendelse af saadanne forbindelser til fremstilling af anticancermidler
DK97889D0 (da)	1989-03-01	Fremgangsmaade til fremstilling af 4,4'-dibrombiphenyl
DK160991C (da)	1991-11-11	5,14-dihydrobenzoe5,6aaisoindolooe2,1-baaisoquinolin-8,13-dionderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse
DK39789A (da)	1989-08-09	Fremgangsmaade til fremstilling af n-phosphonmethyliminodieddikesyre
DK708388D0 (da)	1988-12-20	Pigmentprecursorpraeparat, pigment, fremgangsmaade til fremstilling af et saadant praeparat og fremgangsmaade til fremstillling af et saadant pigment
DK123488A (da)	1988-09-10	2-oxa-isocephemforbindelser, praeparater indeholdende dem, og fremgangsmaader til fremstilling af dem
DK711988D0 (da)	1988-12-21	Methyltetrahydropyridyloxadiazol, farmaceutisk praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse
DK616886D0 (da)	1986-12-19	Optisk aktive 2-klor-12-(3-metylamino-2-metylpropyl)-12h-dibenzo(d,g)(1,3,6)dioxazociner og en fremgangsmaade til fremstilling deraf
DK289684A (da)	1984-12-15	Carboxylsyreamidforbindelse, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse
DK27988D0 (da)	1988-01-21	Fremgangsmaade til fremstilling af substituerede benzaldehyder
DK75287A (da)	1987-08-16	Fremgangsmaade til fremstilling af et butanonderivat
DK74987A (da)	1987-08-16	Fremgangsmaade til fremstilling af et butanonderivat
DK246687A (da)	1987-11-17	Fremgangsmaade til fremstilling af mikroorganismelipase og til foroegelse af dennes maalelige aktivitet

Legal Events

Date	Code	Title	Description
1994-08-22	AHB	Application shelved due to non-payment