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DK675787A - 8-substituerede 2-aminotetraliner, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler - Google Patents

8-substituerede 2-aminotetraliner, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler

Info

Publication number
DK675787A
DK675787A DK675787A DK675787A DK675787A DK 675787 A DK675787 A DK 675787A DK 675787 A DK675787 A DK 675787A DK 675787 A DK675787 A DK 675787A DK 675787 A DK675787 A DK 675787A
Authority
DK
Denmark
Prior art keywords
aminotetralines
medicines
procedures
substituted
preparation
Prior art date
Application number
DK675787A
Other languages
English (en)
Other versions
DK675787D0 (da
Inventor
Bodo Junge
Bernd Richter
Joerg Traber
George S Allen
Thomas Glaser
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK675787D0 publication Critical patent/DK675787D0/da
Publication of DK675787A publication Critical patent/DK675787A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/16—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings
    • C07C211/19—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings other than six-membered aromatic rings containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK675787A 1986-12-22 1987-12-21 8-substituerede 2-aminotetraliner, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler DK675787A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3643899 1986-12-22
DE19873719924 DE3719924A1 (de) 1986-12-22 1987-06-15 8-substituierte 2-aminotetraline

Publications (2)

Publication Number Publication Date
DK675787D0 DK675787D0 (da) 1987-12-21
DK675787A true DK675787A (da) 1988-06-23

Family

ID=25850693

Family Applications (1)

Application Number Title Priority Date Filing Date
DK675787A DK675787A (da) 1986-12-22 1987-12-21 8-substituerede 2-aminotetraliner, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler

Country Status (14)

Country Link
US (3) US4873262A (da)
EP (1) EP0272534A3 (da)
JP (1) JP2596956B2 (da)
KR (1) KR880007432A (da)
CN (1) CN87101285A (da)
AU (1) AU613884B2 (da)
DE (1) DE3719924A1 (da)
DK (1) DK675787A (da)
FI (1) FI875598A (da)
HU (1) HUT46653A (da)
IL (1) IL84875A0 (da)
NO (1) NO167282C (da)
NZ (1) NZ222977A (da)
PT (1) PT86425B (da)

Families Citing this family (55)

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US5177112A (en) * 1983-01-03 1993-01-05 Whitby Research, Inc. Substituted 2-aminotetralins
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
DE3852589T2 (de) * 1987-08-12 1995-08-10 Sanofi Sa Verfahren zur O-Alkylierung von N-(Hydroxy)aralkylphenylethanolamin.
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
CA1331191C (en) 1988-03-25 1994-08-02 Bengt Ronny Andersson Therapeutically useful tetralin derivatives
US5214156A (en) * 1988-03-25 1993-05-25 The Upjohn Company Therapeutically useful tetralin derivatives
GB8810748D0 (en) * 1988-05-06 1988-06-08 Beecham Wuelfing Gmbh & Co Kg Novel treatment
US5162375A (en) * 1988-05-06 1992-11-10 Beecham Group P.L.C. Treatment of neuronal degeneration with 5HT1A agonists
EP0452390B1 (en) * 1989-01-09 1994-10-26 The Upjohn Company Halo substituted aminotetralins
US5225596A (en) * 1989-01-09 1993-07-06 The Upjohn Company Halo substituted aminotetralins
CA1335106C (en) * 1989-02-27 1995-04-04 John Mehnert Schaus Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
ZA901277B (en) * 1989-02-27 1991-10-30 Lilly Co Eli Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes
GB8907865D0 (en) * 1989-04-07 1989-05-24 Wyeth John & Brother Ltd Tetrahydroquinoline derivatives
SE8901889D0 (sv) * 1989-05-26 1989-05-26 Astra Ab Novel 8-substituted-2-aminotetralines
US5545755A (en) * 1989-05-31 1996-08-13 The Upjohn Company Therapeutically useful 2-aminotetralin derivatives
DK0476016T3 (da) * 1989-05-31 1999-07-05 Upjohn Co CNS-aktive 8-heterocyclyl-2-aminotetralin-derivater
DE3919624A1 (de) * 1989-06-15 1990-12-20 Boehringer Ingelheim Kg Neue 2,5-diaminotetraline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DK0482084T3 (da) * 1989-07-13 1997-11-03 Upjohn Co (1,2N)- og (3,2N)-carbocyklisk-2-amino-tetralin-derivater.
US5486611A (en) * 1989-07-13 1996-01-23 The Upjohn Company Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives
DE3924365A1 (de) * 1989-07-22 1991-01-24 Boehringer Ingelheim Kg 2-amino-7-carbamoyl-1,2,3,4- tetrahydronaphthaline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US5616610A (en) * 1989-12-22 1997-04-01 Astra Aktiebolag (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
AU658134B2 (en) * 1989-12-28 1995-04-06 Virginia Commonwealth University Sigma receptor ligands and the use thereof
HUT57185A (en) * 1990-03-21 1991-11-28 Merrell Dow Pharma Process for producing 8-sulfamil-methylen-2-amino-tetraline derivatives and pharmaceutical compositions containing them
US5194439A (en) * 1990-04-06 1993-03-16 John Wyeth & Brother Limited N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fused cycloalkanes
US5340838A (en) * 1990-05-04 1994-08-23 Eli Lilly And Company Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
US5258379A (en) * 1990-05-04 1993-11-02 Eli Lilly And Company Method of inhibiting gastric acid secretion with n-arylpiperazines
US5096908A (en) * 1990-05-04 1992-03-17 Eli Lilly And Company Method of inhibiting gastric acid secretion
ATE149480T1 (de) * 1990-08-15 1997-03-15 Lilly Co Eli Ring-substituierte 2-amino-1,2,3,4-tetra- hydronaphthaline, 3-aminochromane und 3- aminothiochromane
US5252586A (en) * 1990-09-28 1993-10-12 The Du Pont Merck Pharmaceutical Company Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents
ATE197145T1 (de) * 1991-02-08 2000-11-15 Lilly Co Eli Ringsubstituierte 2-amino-1,2,3,4- tetrahydronaphtahline und 3-aminochromane
EP0586553A1 (en) * 1991-05-20 1994-03-16 The Upjohn Company Carboxamido-(3,2n)-carbocyclic-2-aminotetralin derivatives
ES2103374T3 (es) * 1991-05-20 1997-09-16 Upjohn Co Derivados de carboxamido-(1,2n)-carbociclo-2-aminotetralina.
PT100639A (pt) * 1991-06-27 1993-09-30 Univ Virginia Commonwealth Metodo para o tratamento terapeutico com compostos que sao ligandos ao receptor sigma e compostos ai utilizados, nomeadamente derivados fenilalquil-amina, aminotetralina,piperazina e piperidina
US5288749A (en) * 1991-12-20 1994-02-22 Abbott Laboratories Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors
FR2686339B1 (fr) * 1992-01-22 1994-03-11 Adir Cie Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5194658A (en) * 1992-03-02 1993-03-16 The Dow Chemical Company Process for making 2-amino-3-methyl-1-naphthalenecarbonitrile
ZA944513B (en) * 1993-06-23 1996-01-16 Cambridge Neuroscience Inc Sigma receptor ligands
GB9315566D0 (en) * 1993-07-28 1993-09-08 Smithkline Beecham Plc Medicaments
FR2711140B1 (fr) * 1993-10-12 1996-01-05 Sanofi Sa 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant.
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
ATE247639T1 (de) * 1996-05-31 2003-09-15 Upjohn Co Arylsubstituierte cyclische amine als selektive dopamin-d3-liganden
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) * 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
AU7163598A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company Aminotetralins as 5-ht1dalpha agonists
US6355674B1 (en) 1997-04-30 2002-03-12 Eli Lilly And Company Aminotetralins as 5-HT1D α Agonists
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
US20100006191A1 (en) * 2008-07-09 2010-01-14 Brush Wellman, Inc. HIGH STRENGTH Be/Cu ALLOYS WITH IMPROVED ELECTRICAL CONDUCTIVITY
DE102010020553A1 (de) 2010-05-14 2011-11-17 Bayer Schering Pharma Aktiengesellschaft Substituierte 8-Alkoxy-2-aminotetralin-Derivate und ihre Verwendung
EP2874993B1 (de) 2012-07-20 2016-08-24 Bayer Pharma Aktiengesellschaft Substituierte aminoindan- und aminotetralin-carbonsäuren und ihre verwendung
DK2875003T3 (da) 2012-07-20 2017-02-20 Bayer Pharma AG Nye 5-aminotetrahydroquinolin-2-carboxylsyrer og anvendelsen heraf
US11369583B2 (en) 2017-08-25 2022-06-28 Guangzhou Henovcom Bioscience Co. Ltd Long-acting prodrugs of rasagiline, preparing methods and uses thereof
EP4456896A1 (en) 2021-12-29 2024-11-06 Bayer Aktiengesellschaft Treatment of cardiopulmonary disorders
CN118765272A (zh) 2021-12-29 2024-10-11 拜耳股份公司 制备用作药物活性化合物的(5s)-{[2-(4-羧基苯基)乙基][2-(2-{[3-氯-4'-(三氟甲基)联苯-4-基]甲氧基}苯基)乙基]氨基}-5,6,7,8-四氢喹啉-2-甲酸及其结晶形式的方法

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Publication number Priority date Publication date Assignee Title
FR2407198A1 (fr) * 1977-10-27 1979-05-25 Torii & Co Ltd Esters amino- ou guanidino-1, 2, 3, 4-tetrahydro-1-naphtoiques
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
EP0077122B1 (en) * 1981-09-15 1986-05-07 Imperial Chemical Industries Plc Amino-substituted tetralins and related homocyclic compounds
DE3371781D1 (de) * 1982-09-07 1987-07-02 Yoshitomi Pharmaceutical 1,4-methano-2-benzazepine derivatives
US4510157A (en) * 1982-12-27 1985-04-09 Ayerst, Mckenna & Harrison, Inc. 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives
ATE56944T1 (de) * 1986-07-28 1990-10-15 Whitby Research Inc Substituierte 2-aminotetraline.
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline

Also Published As

Publication number Publication date
NZ222977A (en) 1990-07-26
US4968679A (en) 1990-11-06
DE3719924A1 (de) 1988-06-30
FI875598A0 (fi) 1987-12-18
PT86425B (pt) 1990-11-20
EP0272534A3 (de) 1989-07-26
US5047422A (en) 1991-09-10
KR880007432A (ko) 1988-08-27
HUT46653A (en) 1988-11-28
FI875598A (fi) 1988-06-23
AU613884B2 (en) 1991-08-15
JP2596956B2 (ja) 1997-04-02
NO875005D0 (no) 1987-12-01
DK675787D0 (da) 1987-12-21
NO875005L (no) 1988-06-23
NO167282C (no) 1991-10-23
JPS63190857A (ja) 1988-08-08
AU8302987A (en) 1988-06-30
US4873262A (en) 1989-10-10
EP0272534A2 (de) 1988-06-29
IL84875A0 (en) 1988-06-30
NO167282B (no) 1991-07-15
CN87101285A (zh) 1988-08-17
PT86425A (en) 1988-01-01

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